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12 papers found.
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18F-flortaucipir (AV-1451) tau PET in frontotemporal dementia syndromes

BackgroundThe tau positron emission tomography (PET) ligand 18F-flortaucipir binds to paired helical filaments of tau in aging and Alzheimer’s disease (AD), but its utility in detecting tau aggregates in frontotemporal dementia (FTD) is uncertain.MethodsWe performed 18F-flortaucipir imaging in patients with the FTD syndromes (n = 45): nonfluent variant primary progressive aphasia...

Differences in Prefrontal, Limbic, and White Matter Lesion Volumes According to Cognitive Status in Elderly Patients with First-Onset Subsyndromal Depression

The purpose of this preliminary study was to test the hypothesis that subsyndromal depression is associated with the volume of medial prefrontal regional gray matter and that of white matter lesions (WMLs) in the brains of cognitively normal older people. We also explored the relationships between subsyndromal depression and medial prefrontal regional gray matter volume, limbic...

Molecular neuroimaging in Alzheimer’s disease

William Jagust 0 1 0 M.D. , Helen Wills Neuroscience Institute , Barker Hall Mail Code 3190, University of California Berkeley , Berkeley, CA 94720 1 School of Public Health and Helen Wills

Temporal Lobe Metabolic Differences in Medication-Free Outpatients with Schizophrenia via the PET-600

Regional cerebral glucose metabolic rates (rCMRglc) were compared in 18 unmedicated outpatients with schizophrenia and 11 normal controls using high resolution positron emission tomography (PET) and the tracer [F-18]-2-fluoro-2D-deoxyglucose (FDG). From previous work we expected to see abnormal hippocampal rCMRglc in the patients, but no striatal abnormalities. Trial-by-trial...

Large-scale genomics unveil polygenic architecture of human cortical surface area

, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Zaven Khachaturian, Greg Sorensen, Maria Carrillo, Lew Kuller, Marc

Longitudinal measurement and hierarchical classification framework for the prediction of Alzheimer’s disease

FargherConsortiaThe Alzheimer’s Disease Neuroimaging InitiativeMichael W. Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack Jr., William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green

Robust Identification of Alzheimer’s Disease subtypes based on cortical atrophy patterns

Accumulating evidence suggests that Alzheimer’s disease (AD) is heterogenous and can be classified into several subtypes. Here, we propose a robust subtyping method for AD based on cortical atrophy patterns and graph theory. We calculated similarities between subjects in their atrophy patterns throughout the whole brain, and clustered subjects with similar atrophy patterns using...

Basal forebrain degeneration precedes and predicts the cortical spread of Alzheimer’s pathology

. FurstConsortiaThe Alzheimer's Disease Neuroimaging InitiativeMichael W. Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green

Effect of CLU genetic variants on cerebrospinal fluid and neuroimaging markers in healthy, mild cognitive impairment and Alzheimer’s disease cohorts

The Clusterin (CLU) gene, also known as apolipoprotein J (ApoJ), is currently the third most associated late-onset Alzheimer’s disease (LOAD) risk gene. However, little was known about the possible effect of CLU genetic variants on AD pathology in brain. Here, we evaluated the interaction between 7 CLU SNPs (covering 95% of genetic variations) and the role of CLU in β-amyloid (A...

Early role of vascular dysregulation on late-onset Alzheimer’s disease based on multifactorial data-driven analysis

, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Zaven Khachaturian, Greg Sorensen, Lew Kuller, Marc

Genetic studies of plasma analytes identify novel potential biomarkers for several complex traits

, Andrian Preda, Steven Potkin, Ruth A. Mulnard, Gaby Thai, Catherine McAdams-Ortiz, Susan Landau, William Jagust, Liana Apostolova, Kathleen Tingus, Ellen Woo, Daniel H.S. Silverman, Po H. Lu, George

Ferritin levels in the cerebrospinal fluid predict Alzheimer’s disease outcomes and are regulated by APOE

, Ronald Petersen, Clifford R. Jack Jr., William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Zaven Khachaturian, Greg Sorensen