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Search: authors:"Winston A. Haynes"

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Gene annotation bias impedes biomedical research

. Haynes AuthorsSearch for Winston A. Haynes in:Nature Research journals • PubMed • Google Scholar Search for Aurelie Tomczak in:Nature Research journals • PubMed • Google Scholar Search for Purvesh Khatri

Methods to increase reproducibility in differential gene expression via meta-analysis

Findings from clinical and biological studies are often not reproducible when tested in independent cohorts. Due to the testing of a large number of hypotheses and relatively small sample sizes, results from whole-genome expression studies in particular are often not reproducible. Compared to single-study analysis, gene expression meta-analysis can improve reproducibility by...

Differential Expression Analysis for Pathways

Life science technologies generate a deluge of data that hold the keys to unlocking the secrets of important biological functions and disease mechanisms. We present DEAP, Differential Expression Analysis for Pathways, which capitalizes on information about biological pathways to identify important regulatory patterns from differential expression data. DEAP makes significant...