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Faecal microbiota changes associated with the moult fast in chinstrap and gentoo penguins

. Author Contributions Data curation: Hyunjun Cho, Jin-Woo Jung, Jeong-Hoon Kim. Formal analysis: Won Young Lee, Hyunjun Cho, Mincheol Kim, Binu Mani Tripathi. Funding acquisition: Hosung Chung, Jeong-Hoon ... Kim. Methodology: Jin-Woo Jung, Jeong-Hoon Kim. Software: Hyunjun Cho. Supervision: Won Young Lee. Writing ? original draft: Won Young Lee, Hyunjun Cho. Writing ? review & editing: Jeong-Hoon Kim

Maintenance of body weight is an important determinant for the risk of ischemic stroke: A nationwide population-based cohort study

: HC16C2285). We express special thanks to the Taskforce Team of the Obesity Fact Sheet of the Korean Society for the Study of Obesity. Professor Won-Young Lee, the corresponding author of this manuscript is ... ). Author Contributions Conceptualization: Se Eun Park, Hyemi Kwon, Soon-Jib Yoo, Yang-Hyun Kim, Won-Young Lee. Data curation: Jin-Hyung Jung, Kyung-Do Han, Yong-Gyu Park. Formal analysis: Jin-Hyung Jung

Group association and vocal behaviour during foraging trips in Gentoo penguins

In contrast to their terrestrial call, the offshore call of penguins during their foraging trips has been poorly studied due to the inaccessibility of the foraging site—the open ocean—to researchers. Here, we present the first description of the vocal behaviour of penguins in the open ocean and discuss the function of their vocal communication. We deployed an animal-borne camera...

Increased risk for diabetes development in subjects with large variation in total cholesterol levels in 2,827,950 Koreans: A nationwide population-based study

Background Recent studies suggest a role for hyperlipidemia in the development of diabetes. The aim of this study is to analyze the relationship between variations of total cholesterol (TC) levels and the risk for type 2 diabetes development from a Korean nationwide population-based database. Materials and methods We examined the General Health Check-up sub-dataset of the Korean...

Increased risk for development of coronary artery calcification in subjects with non-alcoholic fatty liver disease and systemic inflammation

Background Recent studies have suggested the importance of non-alcoholic fatty liver disease (NAFLD) and systemic inflammation in the development of atherosclerosis. The aim of this study was to compare the risk for coronary artery calcification (CAC) development according to the status of NAFLD and inflammation over four years of follow-up in subjects without baseline CAC...

Insulin resistance contributes more to the increased risk for diabetes development in subjects with low lipoprotein(a) level than insulin secretion

Background Recent studies suggest an association between Lipoprotein(a) [Lp(a)] and the development of diabetes mellitus. We analyzed the association between baseline Lp(a) levels and diabetes development after 4 years of follow-up, in a population of apparently healthy Korean subjects. Methods A total of 2,536 non-diabetic participants (mean age: 41 years, men: 92%) of a health...

Impact of carotid atherosclerosis detection on physician and patient behavior in the management of type 2 diabetes mellitus: a prospective, observational, multicenter study

Background This study compared carotid ultrasound (CUS) and traditional risk calculations in determining cardiovascular disease (CVD) risk in patients with type 2 diabetes mellitus (DM) and investigated whether awareness of CVD affects patient and/or physician behavior. Methods In this prospective, observational, multicenter study, 797 participants with type 2 diabetes were...

Ultrasonic-Assisted Extraction of Raspberry Seed Oil and Evaluation of Its Physicochemical Properties, Fatty Acid Compositions and Antioxidant Activities

Ultrasonic-assisted extraction was employed for highly efficient separation of aroma oil from raspberry seeds. A central composite design with two variables and five levels was employed and effects of process variables of sonication time and extraction temperature on oil recovery and quality were investigated. Optimal conditions predicted by response surface methodology were...

Exendin-4 Inhibits Hepatic Lipogenesis by Increasing β-Catenin Signaling

The aim of this study is to investigate whether the beneficial effect of exendin-4 on hepatic steatosis is mediated by β-catenin signaling. After the HepG2 human hepatoma cells were treated with PA for 24 hours, total triglycerides levels were increased in a dose-dependent manner, and the expression levels of perilipin family members were upregulated in cells treated with 400 μM...

Predictive Value of Triglyceride Glucose Index for the Risk of Incident Diabetes: A 4-Year Retrospective Longitudinal Study

The Triglyceride Glucose Index (TyG index) is considered a surrogate marker of insulin resistance. The aim of this study is to investigate whether the TyG index has a predictive role in identifying individuals with a high risk of incident diabetes and to compare it with other indicators of metabolic health. A total 2900 non-diabetic adults who attended five consecutive annual...

The relationship between serum fatty-acid binding protein 4 level and lung function in Korean subjects with normal ventilatory function

Background The aim of this study was to assess the association of lung function with serum fatty-acid binding protein 4 (FABP4) in apparently healthy Korean adults. Methods In 495 participants in a health screening program, Force Exploratory Volume (FEV) 1 and Forced Vital Capacity (FVC) were assessed with standard spirometry. Subjects with obstructive (n = 19) and restrictive (n...

Identification of Putative Biomarkers for the Early Stage of Porcine Spermatogonial Stem Cells Using Next-Generation Sequencing

To identify putative biomarkers of porcine spermatogonial stem cells (pSSCs), total RNA sequencing (RNA-seq) analysis was performed on 5- and 180-day-old porcine testes and on pSSC colonies that were established under low temperature culture conditions as reported previously. In total, 10,184 genes were selected using Cufflink software, followed by a logarithm and quantile...

Circulating CTRP1 Levels in Type 2 Diabetes and Their Association with FGF21

 Eun-Jung Rhee,3 Won-Young Lee,3 and Young Yang1 1Department of Biological Sciences, Sookmyung Women’s University, 04310 Seoul, Republic of Korea 2Department of Internal Medicine, Konyang University ... Won-Young Lee contributed equally to the work reported. Acknowledgments This research was supported by the Bio & Medical Technology Development Program of the NRF, funded by the Korean government

Effect of Incubation on Bacterial Communities of Eggshells in a Temperate Bird, the Eurasian Magpie (Pica pica)

Inhibitory effect of incubation on microbial growth has extensively been studied in wild bird populations using culture-based methods and conflicting results exist on whether incubation selectively affects the growth of microbes on the egg surface. In this study, we employed culture-independent methods, quantitative PCR and 16S rRNA gene pyrosequencing, to elucidate the effect of...

Subculture of Germ Cell-Derived Colonies with GATA4-Positive Feeder Cells from Neonatal Pig Testes

Enrichment of spermatogonial stem cells is important for studying their self-renewal and differentiation. Although germ cell-derived colonies (GDCs) have been successfully cultured from neonatal pig testicular cells under 31°C conditions, the short period of in vitro maintenance (<2 months) limited their application to further investigations. To develop a culture method that...

Higher association of coronary artery calcification with non-alcoholic fatty liver disease than with abdominal obesity in middle-aged Korean men: the Kangbuk Samsung Health Study

Background It is uncertain whether non-alcoholic fatty liver disease (NAFLD) or abdominal obesity is more associated with atherosclerosis. The aim of this study was to determine whether NAFLD or abdominal obesity is more strongly associated with subclinical atherosclerosis represented by coronary artery calcification (CAC). Methods A total of 21,335 male participa nts in a health...

Depot-Specific Changes in Fat Metabolism with Aging in a Type 2 Diabetic Animal Model

Visceral fat accretion is a hallmark of aging and is associated with aging-induced metabolic dysfunction. PPARγ agonist was reported to improve insulin sensitivity by redistributing fat from visceral fat to subcutaneous fat. The purpose of this study was to investigate the underlying mechanisms by which aging affects adipose tissue remodeling in a type 2 diabetic animal model and...

Identification and In Vitro Derivation of Spermatogonia in Beagle Testis

Background In vitro culture of spermatogonial stem cells (SSCs) is important for exploration of SSCs self-renewal, differentiation, and manipulation. There are several reports on rodent SSC cultures; however, data on SSC cultures in domestic animals are limited. To provide basic scientific information on canine SSC cultures, we report canine testes development, and the...

Photophysical Properties of Pheophorbide-a Derivatives and Their Photodynamic Therapeutic Effects on a Tumor Cell Line In Vitro

,1 Si-Hwan Ko,2 Won-Young Lee,2 Chang-Hee Lee,3 Seok Hoon Jung,4 and Yong-Rok Kim1 1Department of Chemistry, Yonsei University, 50 Yonsero, Seodaemun-Gu, Seoul 120-749, Republic of Korea 2Department

Photophysical Properties of Pheophorbide-a Derivatives and Their Photodynamic Therapeutic Effects on a Tumor Cell Line In Vitro

,1 Si-Hwan Ko,2 Won-Young Lee,2 Chang-Hee Lee,3 Seok Hoon Jung,4 and Yong-Rok Kim1 1Department of Chemistry, Yonsei University, 50 Yonsero, Seodaemun-Gu, Seoul 120-749, Republic of Korea 2Department