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Impact of acupuncture treatment on the lumbar surgery rate for low back pain in Korea: A nationwide matched retrospective cohort study

sessions for subjects in the acupuncture group. p value from independent t-test SD, standard deviation. (DOCX) Author Contributions Conceptualization: Wonil Koh, Kyungwon Kang, Yoon Jae Lee. Data ... curation: Kyungwon Kang, Me-riong Kim, Joon-Shik Shin. Formal analysis: Wonil Koh, Yoon Jae Lee, Me-riong Kim, Joon-Shik Shin, Jinho Lee, Jun Hwan Lee, Kyung-Min Shin, In-Hyuk Ha. Funding acquisition: In

The Anti-Inflammatory Effects of Shinbaro3 Is Mediated by Downregulation of the TLR4 Signalling Pathway in LPS-Stimulated RAW 264.7 Macrophages

, Sang Kook Lee, Wonil Koh, and In-Hyuk Ha conceptualized and designed the study. Won Kyung Kim, Joon-Shik Shin, and Jinho Lee acquired the data. Wonil Koh and Hwa-Jin Chung analysed and interpreted the ... data. Wonil Koh and Hwa-Jin Chung drafted the article. In-Hyuk Ha, Won Kyung Kim, Hwa-Jin Chung, and Sang Kook Lee critically revised the draft. All authors read and approved the final manuscript

In Vitro and In Vivo Anti-Allergic and Anti-Inflammatory Effects of eBV, a Newly Developed Derivative of Bee Venom, through Modulation of IRF3 Signaling Pathway in a Carrageenan-Induced Edema Model

Background Bee venom (BV), a type of toxin extracted from honeybees (Apis mellifera), has been empirically and widely used to treat inflammatory diseases throughout Asia. Essential BV (eBV) was developed by removing phospholipase A2 (PLA2) and histamine to lower occurrence of allergic reaction. This study investigated the anti-allergic and anti-inflammatory activities of eBV in...

Inhibition of STAT3 signaling and induction of SHP1 mediate antiangiogenic and antitumor activities of ergosterol peroxide in U266 multiple myeloma cells

Background Ergosterol peroxide (EP) derived from edible mushroom has been shown to exert anti-tumor activity in several cancer cells. In the present study, anti-angiogenic activity of EP was investigated with the underlying molecular mechanisms in human multiple myeloma U266 cells. Results Despite weak cytotoxicity against U266 cells, EP suppressed phosphorylation, DNA binding...

Icariside II Induces Apoptosis in U937 Acute Myeloid Leukemia Cells: Role of Inactivation of STAT3-Related Signaling

Background The aim of this study is to determine anti-cancer effect of Icariside II purified from the root of Epimedium koreanum Nakai on human acute myeloid leukemia (AML) cell line U937. Methodology/Principal Findings Icariside II blocked the growth U937 cells in a dose- and time-dependent manner. In this anti-proliferation process, this herb compound rendered the cells...

Oral administration of penta-O-galloyl-β-D-glucose suppresses triple-negative breast cancer xenograft growth and metastasis in strong association with JAK1-STAT3 inhibition

There is an urgent clinical need for chemotherapeutic and chemopreventive drugs for triple-negative breast cancer (TNBCa). Extending on our recent work, we hypothesize that the herbal compound 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG) can inhibit the growth and metastasis of TNBCa xenograft and target Janus-activated kinase (JAK)-signal transducer and activator of...