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Impact of Etoposide on BRCA1 Expression in Various Breast Cancer Cell Lines

the topic and contributed to manuscript editing. SS supervised the research. All authors read and approved the final manuscript. Compliance with Ethical Standards Conflict of Interest Xi Zhang, Simone

Aqp5 Is a New Transcriptional Target of Dot1a and a Regulator of Aqp2

Dot1l encodes histone H3 K79 methyltransferase Dot1a. Mice with Dot1l deficiency in renal Aqp2-expressing cells (Dot1lAC) develop polyuria by unknown mechanisms. Here, we report that Aqp5 links Dot1l deletion to polyuria through Aqp2. cDNA array analysis revealed and real-time RT-qPCR validated Aqp5 as the most upregulated gene in Dot1lAC vs. control mice. Aqp5 protein is barely...

Genomes of the rice pest brown planthopper and its endosymbionts reveal complex complementary contributions for host adaptation

Background The brown planthopper, Nilaparvata lugens, the most destructive pest of rice, is a typical monophagous herbivore that feeds exclusively on rice sap, which migrates over long distances. Outbreaks of it have re-occurred approximately every three years in Asia. It has also been used as a model system for ecological studies and for developing effective pest management. To...