Advanced search    

Search: authors:"Xi Zhang"

3 papers found.
Use AND, OR, NOT, +word, -word, "long phrase", (parentheses) to fine-tune your search.

FamAnn: an automated variant annotation pipeline to facilitate target discovery for family-based sequencing studies

Summary: FamAnn is an automated variant annotation pipeline designed for facilitating target discovery for family-based sequencing studies. It can apply a different inheritance pattern or a de novo mutations discovery model to each family and select single nucleotide variants and small insertions and deletions segregating in each family or shared by multiple families. It also...

Pandora, a PAthway and Network DiscOveRy Approach based on common biological evidence

Kelvin Xi Zhang 0 1 B. F. Francis Ouellette 0 Associate Editor: John Quackenbush 0 Ontario Institute for Cancer Research, MaRS Centre , South Tower, 101 College Street , Toronto , Ontario, M5G 0A3

Molecular basis for specificity in the druggable kinome: sequence-based analysis

Motivation: Rational design of kinase inhibitors remains a challenge partly because there is no clear delineation of the molecular features that direct the pharmacological impact towards clinically relevant targets. Standard factors governing ligand affinity, such as potential for intermolecular hydrophobic interactions or for intermolecular hydrogen bonding do not provide good...