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Association between maternal HIV infection and low birth weight and prematurity: a meta-analysis of cohort studies

Background To assess the association between maternal human immunodeficiency virus (HIV) infection and low birth weight (LBW)/prematurity (PTD), we conducted a meta-analysis of cohort studies of HIV infected and uninfected women. Methods Several English and Chinese databases were searched (updated to May 2015) to find the studies reporting infant outcomes associated with exposure...

Downregulated miR-195 Detected in Preeclamptic Placenta Affects Trophoblast Cell Invasion via Modulating ActRIIA Expression

Background Preeclampsia (PE) is a pregnancy-specific syndrome manifested by on-set of hypertension and proteinuria after 20 weeks of gestation. Abnormal placenta development has been generally accepted as initial cause of the disorder. Recently, miR-195 was found to be down-regulated in preeclamptic placentas compared with normal pregnant ones, indicating possible association of...

Integrative Genomics Reveals Novel Molecular Pathways and Gene Networks for Coronary Artery Disease

Nilesh J. Samani Heribert Schunkert Thomas Quertermous Ruth McPherson Xia Yang Themistocles L. Assimes The majority of the heritability of coronary artery disease (CAD) remains unexplained, despite