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The lithic assemblages of Donggutuo, Nihewan basin: Knapping skills of Early Pleistocene hominins in North China

insightful comments, which helped us to improve this article. Author Contributions Data curation: Shi-Xia Yang, Jian-Ping Yue. Formal analysis: Jian-Ping Yue. Funding acquisition: Shi-Xia Yang, Cheng-Long ... Deng, Ri-Xiang Zhu. Project administration: Shi-Xia Yang, Michael D. Petraglia, Ya-Mei Hou, Ri-Xiang Zhu. Resources: Ya-Mei Hou. Writing ± original draft: Shi-Xia Yang, Michael D. Petraglia. Writing

ABO Blood Group and the Risk of Hepatocellular Carcinoma: A Case-Control Study in Patients with Chronic Hepatitis B

Background Studies have observed an association between the ABO blood group and risk of certain malignancies. However, no studies of the association with hepatocellular carcinoma (HCC) risk are available. We conducted this hospital-based case-control study to examine the association with HCC in patients with chronic hepatitis B (CHB). Methods From January 2004 to December 2008, a...

Integrative Genomics Reveals Novel Molecular Pathways and Gene Networks for Coronary Artery Disease

Nilesh J. Samani Heribert Schunkert Thomas Quertermous Ruth McPherson Xia Yang Themistocles L. Assimes The majority of the heritability of coronary artery disease (CAD) remains unexplained, despite

Gene–environment interactions between alcohol drinking and the MTHFR C677T polymorphism impact on esophageal cancer risk: results of a case–control study in Japan

Folate takes part in two biological pathways involved in DNA methylation and synthesis, and a potential protective influence of this nutrient chemical against carcinogenicity has been recognized in several sites, including the esophagus. Therefore, the functional polymorphisms in genes encoding folate metabolizing enzymes, MTHFR C677T and MTR A2756G, might be suspected of...

A Meta-analysis of Gene Expression Signatures of Blood Pressure and Hypertension

Genome-wide association studies (GWAS) have uncovered numerous genetic variants (SNPs) that are associated with blood pressure (BP). Genetic variants may lead to BP changes by acting on intermediate molecular phenotypes such as coded protein sequence or gene expression, which in turn affect BP variability. Therefore, characterizing genes whose expression is associated with BP may...