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Ascorbic acid induces global epigenetic reprogramming to promote meiotic maturation and developmental competence of porcine oocytes

L-ascorbic acid (Vitamin C) can enhance the meiotic maturation and developmental competence of porcine oocytes, but the underlying molecular mechanism remains obscure. Here we show the role of ascorbic acid in regulating epigenetic status of both nucleic acids and chromatin to promote oocyte maturation and development in pigs. Supplementation of 250 μM L-ascorbic acid 2-phosphate...

DMBA acts on cumulus cells to desynchronize nuclear and cytoplasmic maturation of pig oocytes

As an environmental pollutant and carcinogen, 7,12-dimethylbenz[a]anthracene (DMBA) can destroy ovarian follicles at all developmental stages in rodents. However, the underlying molecular mechanism remains obscure. In the present study, we aim to address how DMBA affects the in vitro maturation and development of porcine oocytes. We discovered that for 20 μM DMBA-treated cumulus...

The healing of alveolar bone defects with novel bio-implants composed of Ad-BMP9-transfected rDFCs and CHA scaffolds

Cells, scaffolds, and growth factors play important roles in bone regeneration. Bone morphogenetic protein 9 (BMP9), a member of BMP family, could facilitate osteogenesis by regulating growth factors and promoting angiogenesis. Similar to other stem cells, rat dental follicle stem cells (rDFCs), the precursor cells of cementoblasts, osteoblasts and periodontal ligament cells, can...

Luteolin, a natural flavonoid, inhibits methylglyoxal induced apoptosis via the mTOR/4E-BP1 signaling pathway

Methylglyoxal (MG) accumulation has been observed in human cerebrospinal fluid and body tissues under hyperglycaemic conditions. Recent research has demonstrated that MG-induces neuronal cell apoptosis, which promotes the development of diabetic encephalopathy. Our previous animal study has shown that luteolin, a natural flavonoid, attenuates diabetes-associated cognitive...

ZP3 is Required for Germinal Vesicle Breakdown in Mouse Oocyte Meiosis

-Lei Gao, Chun-Xiang Zhou, Xiao-Lan Zhang, Peng Liu, Zhen Jin, Gang-Yi Zhu, Yang Ma, Jing Li, Zhi-Xia Yang & Dong Zhang AuthorsSearch for Lei-Lei Gao in:Nature Research journals • PubMed • Google ... in:Nature Research journals • PubMed • Google ScholarSearch for Jing Li in:Nature Research journals • PubMed • Google ScholarSearch for Zhi-Xia Yang in:Nature Research journals • PubMed • Google ScholarSearch