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Eukaryotic initiation factor 4A2 promotes experimental metastasis and oxaliplatin resistance in colorectal cancer

Deregulation of protein translation control is a hallmark of cancers. Eukaryotic initiation factor 4A2 (EIF4A2) is required for mRNA binding to ribosome and plays an important role in translation initiation. However, little is known about its functions in colorectal cancer (CRC). Analysis of CRC transcriptome data from TCGA identified that EIF4A2 was associated with poor...

Zinc deficiency and cellular oxidative stress: prognostic implications in cardiovascular diseases

Zinc is an essential nutrient for human health and has anti-oxidative stress and anti-inflammatory functions. The association between zinc deficiency and the development of cardiovascular diseases (CVDs) has been supported by numerous studies. Supplementing zinc can reduce the risk of atherosclerosis and protect against myocardial infarction and ischemia/reperfusion injury. In...

QTL mapping and genetic effect of chromosome segment substitution lines with excellent fiber quality from Gossypium hirsutum × Gossypium barbadense

Chromosome segment substitution lines (CSSLs) are ideal materials for identifying genetic effects. In this study, CSSL MBI7561 with excellent fiber quality that was selected from BC4F3:5 of CCRI45 (Gossypium hirsutum) × Hai1 (Gossypium barbadense) was used to construct 3 secondary segregating populations with 2 generations (BC5F2 and BC5F2:3). Eighty-one polymorphic markers...

Exploitation of fractured shale oil resources by cyclic CO2 injection

With shale oil reservoir pressure depletion and recovery of hydrocarbons from formations, the fracture apertures and conductivity are subject to reduction due to the interaction between stress effects and proppants. Suppose most of the proppants were concentrated in dominant fractures rather than sparsely allocated in the fracture network, the fracture conductivity would be less...

The impairing effects of mental fatigue on response inhibition: An ERP study

, Xian Liu, Yan Zheng. Funding acquisition: Zizheng Guo, Jun Zhang. Investigation: Ruiya Chen, Xian Liu, Yan Zheng. Methodology: Zizheng Guo, Guozhen Zhao. Project administration: Jun Zhang. Resources ... : Jun Zhang. Supervision: Zizheng Guo, Guozhen Zhao, Mingliang Gong, Jun Zhang. Visualization: Ruiya Chen, Xian Liu. Writing ± original draft: Zizheng Guo, Ruiya Chen, Xian Liu. Writing ± review

Solid-phase microextraction-based cuticular hydrocarbon profiling for intraspecific delimitation in Acyrthosiphon pisum

. Funding acquisition: Yong-Liang Fan, Tong-Xian Liu. Investigation: Nan Chen, Yu Bai. Methodology: Nan Chen, Yu Bai, Yong-Liang Fan. Project administration: Yong-Liang Fan, Tong-Xian Liu. Resources: Yong ... -Liang Fan, Tong-Xian Liu. Software: Nan Chen. Supervision: Yong-Liang Fan, Tong-Xian Liu. Validation: Nan Chen, Yong-Liang Fan, Tong-Xian Liu. Visualization: Nan Chen, Yu Bai. Writing ± original

Improving deep convolutional neural networks with mixed maxout units

open access. The authors would like to thank all of the team members of D605 Laboratory. Author Contributions Conceptualization: Hui-zhen Zhao. Data curation: Hui-zhen Zhao, Fu-xian Liu. Formal ... analysis: Hui-zhen Zhao, Long-yue Li. Funding acquisition: Fu-xian Liu. Investigation: Hui-zhen Zhao. Methodology: Hui-zhen Zhao, Fu-xian Liu. Project administration: Hui-zhen Zhao. Resources: Hui-zhen

Circulating microRNA signature for the diagnosis of childhood dilated cardiomyopathy

journals • PubMed • Google Scholar Search for Hui Yuan in:Nature Research journals • PubMed • Google Scholar Search for Yu-Lin Li in:Nature Research journals • PubMed • Google Scholar Search for Wen-Xian ... Liu in:Nature Research journals • PubMed • Google Scholar Search for Mei Jin in:Nature Research journals • PubMed • Google Scholar Search for Jie Du in:Nature Research journals • PubMed • Google

Adiponectin regulates BMSC osteogenic differentiation and osteogenesis through the Wnt/β-catenin pathway

Recent studies have demonstrated the stimulatory effects of adiponectin on bone formation, but the mechanism underlying these effects remains unclear. The Wnt/β-catenin pathway, one of the most important pathways in osteogenesis, has rarely been associated with the osteogenic effects of adiponectin in previous studies. The present study was designed to investigate the effects of...

Transnasal endoscopic and combined intra–extranasal approach for the surgical treatment of frontal sinus cerebrospinal fluid rhinorrhea

, Xuekun Huang, Xian Liu, Gehua Zhang Department of Otolaryngology-Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, People’s Republic of China Abstract: The aim of

Regulation of Estrogen Receptor α Expression in the Hypothalamus by Sex Steroids: Implication in the Regulation of Energy Homeostasis

, 700 E. High Street, Oxford, OH 45056, USA Received 19 May 2015; Revised 18 July 2015; Accepted 22 July 2015 Academic Editor: Mario Maggi Copyright © 2015 Xian Liu and Haifei Shi. This is an open ... Department of Biology at Miami University for providing Graduate Assistantship to Xian Liu. References C. L. Ogden, M. D. Carroll, B. K. Kit, and K. M. Flegal, “Prevalence of obesity in the United States

Regulation of Estrogen Receptor α Expression in the Hypothalamus by Sex Steroids: Implication in the Regulation of Energy Homeostasis

, 700 E. High Street, Oxford, OH 45056, USA Received 19 May 2015; Revised 18 July 2015; Accepted 22 July 2015 Academic Editor: Mario Maggi Copyright © 2015 Xian Liu and Haifei Shi. This is an open ... Department of Biology at Miami University for providing Graduate Assistantship to Xian Liu. References C. L. Ogden, M. D. Carroll, B. K. Kit, and K. M. Flegal, “Prevalence of obesity in the United States

Effect of the Reinforce Process on the Fatigue Fracture Properties of Aeronautical Polymethyl Methacrylate

The main purpose of the present work is to investigate fatigue fracture mechanical properties of aeronautical directional polymethyl methacrylate (PMMA) which has been treated by the directional tensile technology. Firstly, the fatigue cracks growth has been tracked in directional PMMA using the stroboscopic method. Then, the digital photoelasticity with a phase-shifting...

Predictive dosimetric parameters for gastrointestinal toxicity with hypofractioned radiotherapy in pancreatic adenocarcinoma

Predictive dosimetric parameters for gastrointestinal toxicity with hypofractioned radiotherapy in pancreatic adenocarcinoma Xian Liu,* Gang Ren,* Liqin Li, Tingyi Xia Department of Radiation

Response of MiRNA-22-3p and MiRNA-149-5p to Folate Deficiency and the Differential Regulation of MTHFR Expression in Normal and Cancerous Human Hepatocytes

Background/Aims Folic acid (FA) is a core micronutrient involved in DNA synthesis/methylation, and the metabolism of FA is responsible for genomic stability. MicroRNAs may affect gene expression during folate metabolism when cellular homeostasis is changed. This study aimed to reveal the relationship between FA deficiency and the expression of miR-22-p/miR-149-5p and the targeted...

Activity and expression of ADP-glucose pyrophosphorylase during rhizome formation in lotus (Nelumbo nucifera Gaertn.)

Background Lotus root is a traditional and popular aquatic vegetable in China. Starch is an important component of the rhizome and directly affects the quality of processed products. ADP -glucose pyrophosphorylase (AGPase) is a rate-limiting enzyme associated with starch biosynthesis in plants. Therefore, in the present study, AGPase activity and NnAGP expression during rhizome...

The potential of domestic production and imports of oil and gas in China: an energy return on investment perspective

Concerns about China’s energy security have escalated because of the country’s high dependency on oil and gas imports, so it is necessary to calculate the availability of domestic oil and gas resources and China’s ability to obtain foreign energy through trade. In this work, the calculation was done by using the energy return on investment (EROI) method. The results showed that...

Population Structure and Adaptive Divergence in a High Gene Flow Marine Fish: The Small Yellow Croaker (Larimichthys polyactis)

The spatial distribution of genetic diversity has been long considered as a key component of policy development for management and conservation of marine fishes. However, unraveling the population genetic structure of migratory fish species is challenging due to high potential for gene flow. Despite the shallow population differentiation revealed by putatively neutral loci, the...

Leaf Morphological Characters Can Be a Factor for Intra-Varietal Preference of Whitefly Bemisia tabaci (Hemiptera: Aleyrodidae) among Eggplant Varieties

The sweetpotato whitefly, Bemisia tabaci (Hemiptera: Aleyrodidae) MEAM1, is considered a serious pest of horticultural and many other crops. While eggplant (Solanum melongena) is one of the most favored host plants, the whiteflies exhibit preferences among different varieties. We hypothesized that certain morphological leaf characteristics of different varieties, like leaf...

Genome-Wide SNP Discovery, Genotyping and Their Preliminary Applications for Population Genetic Inference in Spotted Sea Bass (Lateolabrax maculatus)

Next-generation sequencing and the collection of genome-wide single-nucleotide polymorphisms (SNPs) allow identifying fine-scale population genetic structure and genomic regions under selection. The spotted sea bass (Lateolabrax maculatus) is a non-model species of ecological and commercial importance and widely distributed in northwestern Pacific. A total of 22 648 SNPs was...