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Damage and Fracture Behavior of Rock

-hong Cao Xiang Fan Yixian Wang References W. Wang, S. Zhang, H. Li, S. Gong, Z. Liu, and Y. Liu, “Analysis of the dynamic impact mechanical characteristics of prestressed saturated fractured coal

Experimental and Numerical Study of the Failure Behavior of Intermittent Rock Joints Subjected to Direct Shear Load

@hqhz Received 3 March 2018; Revised 15 May 2018; Accepted 23 May 2018; Published 10 July 2018 Academic Editor: Wei Wu Copyright © 2018 Xiang Fan et al. This is an open access article distributed

Numerical Analysis for the Progressive Failure of Binary-Medium Interface under Shearing

Binary-medium specimens were fabricated using the particle flow code, and the shear strength, dilatancy, and failure behavior of the binary-medium specimens with different bond strength ratios (0.25, 0.5, 0.75, and 1.0) under different normal stresses were studied. Numerical results show that the bond strength ratio and normal stresses considerably influence the shear strengths...

Numerical Analysis for the Progressive Failure of Binary-Medium Interface under Shearing

Binary-medium specimens were fabricated using the particle flow code, and the shear strength, dilatancy, and failure behavior of the binary-medium specimens with different bond strength ratios (0.25, 0.5, 0.75, and 1.0) under different normal stresses were studied. Numerical results show that the bond strength ratio and normal stresses considerably influence the shear strengths...

Cracking and Failure in Rock Specimen Containing Combined Flaw and Hole under Uniaxial Compression

Qihua Zhao; moc.361@hqhz Received 20 September 2017; Revised 3 February 2018; Accepted 18 February 2018; Published 2 May 2018 Academic Editor: Cumaraswamy Vipulanandan Copyright © 2018 Xiang Fan et al

Experimental and numerical study of the failure process and energy mechanisms of rock-like materials containing cross un-persistent joints under uniaxial compression

and exhibits some fluctuation with the increases of α. Author Contributions Conceptualization: Hang Lin. Data curation: Rihong Cao, Hang Lin. Formal analysis: Rihong Cao, Hang Lin, Xiang Fan ... . Funding acquisition: Ping Cao. Methodology: Ping Cao. Software: Rihong Cao. Writing ± review & editing: Xiang Fan. 18 / 20 19 / 20 1. Shen B. The mechanism of fracture coalescence in compression

Experimental and Numerical Evaluation of Rock Dynamic Test with Split-Hopkinson Pressure Bar

Feasibility of rock dynamic properties by split-Hopkinson pressure bar (SHPB) was experimentally and numerically evaluated with ANSYS/LS-DYNA. The effects of different diameters, different loading rates, and different propagation distances on wave dispersion of input bars in SHPB with rectangle and half-sine wave loadings were analyzed. The results show that the dispersion effect...

Experimental and Numerical Evaluation of Rock Dynamic Test with Split-Hopkinson Pressure Bar

Feasibility of rock dynamic properties by split-Hopkinson pressure bar (SHPB) was experimentally and numerically evaluated with ANSYS/LS-DYNA. The effects of different diameters, different loading rates, and different propagation distances on wave dispersion of input bars in SHPB with rectangle and half-sine wave loadings were analyzed. The results show that the dispersion effect...

Experimental and Numerical Evaluation of Rock Dynamic Test with Split-Hopkinson Pressure Bar

Feasibility of rock dynamic properties by split-Hopkinson pressure bar (SHPB) was experimentally and numerically evaluated with ANSYS/LS-DYNA. The effects of different diameters, different loading rates, and different propagation distances on wave dispersion of input bars in SHPB with rectangle and half-sine wave loadings were analyzed. The results show that the dispersion effect...

As a carrier–transporter for hair follicle reconstitution, platelet-rich plasma promotes proliferation and induction of mouse dermal papilla cells

Zhe-Xiang Fan Xiao-Min Liu Zhi-Qi Hu OPEN Morphogenesis of hair follicles during development and in hair reconstitution assays involves complex interactions between epithelial cells and dermal papilla ... experiments. Shun-E. Xiao and Yong Miao performed the cellular biology experiments and statistical analysis. Jin Wang and Wei Jiang conducted the mini-chamber animal assay. Xiao-Min Liu and Zhe-Xiang Fan

Endothelial nitric oxide synthase: a potential therapeutic target for cerebrovascular diseases

Endothelial nitric oxide (NO) is a significant signaling molecule that regulates cerebral blood flow (CBF), playing a pivotal role in the prevention and treatment of cerebrovascular diseases. However, achieving the expected therapeutic efficacy is difficult using direct administration of NO donors. Therefore, endothelial nitric oxide synthase (eNOS) becomes a potential...

Endothelial nitric oxide synthase: a potential therapeutic target for cerebrovascular diseases

Endothelial nitric oxide (NO) is a significant signaling molecule that regulates cerebral blood flow (CBF), playing a pivotal role in the prevention and treatment of cerebrovascular diseases. However, achieving the expected therapeutic efficacy is difficult using direct administration of NO donors. Therefore, endothelial nitric oxide synthase (eNOS) becomes a potential...

Tetramethylpyrazine Produces Antidepressant-Like Effects in Mice Through Promotion of BDNF Signaling Pathway

showed that TMP treatment Zhang wrote the manuscript; Bo Jiang, Xiang-Fan Chen and Wei promotes the expression of BDNF after severe brain injury in Zhang reviewed and edited the manuscript; All authors

Naoxintong Protects Primary Neurons from Oxygen-Glucose Deprivation/Reoxygenation Induced Injury through PI3K-Akt Signaling Pathway

Naoxintong capsule (NXT), developed from Buyang Huanwu Decoction, has shown the neuroprotective effects in cerebrovascular diseases, but the neuroprotection mechanisms of NXT on ischemia/reperfusion injured neurons have not yet been well known. In this study, we established the oxygen-glucose deprivation/reoxygenation (OGD/R) induced neurons injury model and treat the neurons...

Naoxintong Protects Primary Neurons from Oxygen-Glucose Deprivation/Reoxygenation Induced Injury through PI3K-Akt Signaling Pathway

Naoxintong capsule (NXT), developed from Buyang Huanwu Decoction, has shown the neuroprotective effects in cerebrovascular diseases, but the neuroprotection mechanisms of NXT on ischemia/reperfusion injured neurons have not yet been well known. In this study, we established the oxygen-glucose deprivation/reoxygenation (OGD/R) induced neurons injury model and treat the neurons...

Naoxintong Protects Primary Neurons from Oxygen-Glucose Deprivation/Reoxygenation Induced Injury through PI3K-Akt Signaling Pathway

Naoxintong capsule (NXT), developed from Buyang Huanwu Decoction, has shown the neuroprotective effects in cerebrovascular diseases, but the neuroprotection mechanisms of NXT on ischemia/reperfusion injured neurons have not yet been well known. In this study, we established the oxygen-glucose deprivation/reoxygenation (OGD/R) induced neurons injury model and treat the neurons...

Design, synthesis and biological evaluation of hybrids of β-carboline and salicylic acid as potential anticancer and apoptosis inducing agents

). Author information Author notesQi-Bing Xu & Xiang-Fan Chen These authors contributed equally to this work. AffiliationsSchool of Pharmacy and Jiangsu Province Key Laboratory for Inflammation and Molecular ... Drug Target, Nantong University, Nantong 226001, ChinaQi-Bing Xu, Xiang-Fan Chen, Jiao Feng, Ji Liu, Feng-Tao Liu, Bi-Xi Niu, Jin-Yang Cai, Chao Huang, Yanan Zhang & Yong LingState Key Laboratory of

A Novel Method for Simultaneous Production of Two Ribosome-Inactivating Proteins, α-MMC and MAP30, from Momordica charantia L

Alpha-momorcharin (α-MMC) and momordica anti-HIV protein (MAP30) from Momordica charantia L. have been confirmed to possess anti-tumor and anti-virus activities. Traditional purification methods of these two ribosome-inactivating proteins (RIPs) were separate which was time consuming and cost effective as well as low efficient. In order to obtain sufficient samples for researches...

Poliomyelitis Eradication in China: 1953–2012

Background. Poliomyelitis has historically been endemic in China and has been considered an important cause of disability and death. Methods. We reviewed strategies and measures of poliomyelitis control and eradication from 1953 to 2012. Data from notifiable disease and routine immunization reporting systems and acute flaccid paralysis (AFP) surveillance were analyzed. Results...

Cross-border collaboration between China and Myanmar for emergency response to imported vaccine derived poliovirus case

Background This report describes emergency response following an imported vaccine derived poliovirus (VDPV) case from Myanmar to Yunnan Province, China and the cross-border collaboration between China and Myanmar. Immediately after confirmation of the VDPV case, China disseminated related information to Myanmar with the assistance of the World Health Organization. Methods A...