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Polymorphisms in the Promoter Region of Catalase Gene and Essential Hypertension

Genetic variations that predispose individuals to complex disorders, such as essential hypertension, may be found in gene coding regions, intronic regions or in gene promoter regions. Most studies have focused on gene variations that result in amino acid substitutions because they result in different isoforms of the protein, presumably resulting in differences in protein...

Targeting mitochondrial reactive oxygen species as novel therapy for inflammatory diseases and cancers

Xiao-feng Yang 0 0 Cardiovascular Research Center, Department of Pharmacology and Thrombosis Research Center, Temple University School of Medicine , 3500 North Broad Street, Philadelphia, PA 19140 , USA

Targeting mitochondrial reactive oxygen species as novel therapy for inflammatory diseases and cancers

Xiao-feng Yang 0 0 Cardiovascular Research Center, Department of Pharmacology and Thrombosis Research Center, Temple University School of Medicine , 3500 North Broad Street, Philadelphia, PA 19140 , USA

Active sites of copper-complex catalytic materials for electrochemical carbon dioxide reduction

Restructuring-induced catalytic activity is an intriguing phenomenon of fundamental importance to rational design of high-performance catalyst materials. We study three copper-complex materials for electrocatalytic carbon dioxide reduction. Among them, the copper(II) phthalocyanine exhibits by far the highest activity for yielding methane with a Faradaic efficiency of 66% and a...

New targets for controlling Ebola virus disease

Biophysics, Chinese Academy of Sciences , China 4 Department of Microbiology, Immunology and Molecular Genetics, University of California , Los Angeles , USA 5 F. Xiao-Feng Qin - EBOV infects multiple

Oncolytic adenovirus targeting cyclin E overexpression repressed tumor growth in syngeneic immunocompetent mice

Background Clinical trials have indicated that preclinical results obtained with human tumor xenografts in mouse models may overstate the potential of adenovirus (Ad)-mediated oncolytic therapies. We have previously demonstrated that the replication of human Ads depends on cyclin E dysregulation or overexpression in cancer cells. ED-1 cell derived from mouse lung adenocarcinomas...

Pathological conditions re-shape physiological Tregs into pathological Tregs

CD4+FOXP3+ regulatory T cells (Tregs) are a subset of CD4 T cells that play an essential role in maintaining peripheral immune tolerance, controlling acute and chronic inflammation, allergy, autoimmune diseases, and anti-cancer immune responses. Over the past 20 years, a significant progress has been made since Tregs were first characterized in 1995. Many concepts and principles...

Complications are reduced with a protocol to standardize timing of fixation based on response to resuscitation

Background Our group developed a protocol, entitled Early Appropriate Care (EAC), to determine timing of definitive fracture fixation based on presence and severity of metabolic acidosis. We hypothesized that utilization of EAC would result in fewer complications than a historical cohort and that EAC patients with definitive fixation within 36 h would have fewer complications...

Immunosuppressive/anti-inflammatory cytokines directly and indirectly inhibit endothelial dysfunction- a novel mechanism for maintaining vascular function

Endothelial dysfunction is a pathological status of the vascular system, which can be broadly defined as an imbalance between endothelium-dependent vasoconstriction and vasodilation. Endothelial dysfunction is a key event in the progression of many pathological processes including atherosclerosis, type II diabetes and hypertension. Previous reports have demonstrated that pro...

Accuracy of volatile urine biomarkers for the detection and characterization of lung cancer

Background The mixture of volatile organic compounds in the headspace gas of urine may be able to distinguish lung cancer patients from relevant control populations. Methods Subjects with biopsy confirmed untreated lung cancer, and others at risk for developing lung cancer, provided a urine sample. A colorimetric sensor array was exposed to the headspace gas of neat and pre...

Network of co-mutations in Ebola virus genome predicts the disease lethality

, Los Angeles, CA 90095, USA *These three authors contributed equally to this work. Correspondence: Taijiao Jianga, Genhong Chengb, F Xiao-Feng Qinc aE-mail: bE-mail: cE-mail: 1 King AM, eds. Virus

MicroRNAs and Toll-like Receptor/Interleukin-1 Receptor Signaling

The discovery of miRNAs has revolutionized the way we examine the genome, RNA products, and the regulation of transcription and translation. Their ability to modulate protein expression through mRNA degradation and translation repression resulted in avid scientific interest in miRNAs over the past decade. This research has led to findings that indicate miRNAs can regulate an...

ATP directed agent, 8-chloro-adenosine, induces AMP activated protein kinase activity, leading to autophagic cell death in breast cancer cells

Background 8-chloro-adenosine (8-Cl-Ado) is a unique ribonucleoside analog which is currently in a phase I clinical trial for hematological malignancies. Previously, we demonstrated in breast cancer cells that a 3-day treatment with 10 μM 8-Cl-Ado causes a 90% loss of clonogenic survival. In contrast, there was only a modest induction of apoptosis under these conditions...

An evolving new paradigm: endothelial cells – conditional innate immune cells

Endothelial cells (ECs) are a heterogeneous population that fulfills many physiological processes. ECs also actively participate in both innate and adaptive immune responses. ECs are one of the first cell types to detect foreign pathogens and endogenous metabolite-related danger signals in the bloodstream, in which ECs function as danger signal sensors. Treatment with...

Increased HMGB1 and cleaved caspase-3 stimulate the proliferation of tumor cells and are correlated with the poor prognosis in colorectal cancer

Background Dying tumor cells after irradiation could promote the proliferation of living tumor cells might cause tumor relapse and treatment failure. Our previous study showed that activated caspase-3 after irradiation probably participates in tumor repopulation. In this study, we investigated whether high mobility group box 1(HMGB1) is also involved in tumor repopulation...

Endothelial progenitor cells in ischemic stroke: an exploration from hypothesis to therapy

Chernaya Sonia Samuel Su-Xuan Liu 0 Hong Wang 0 Xiao-Feng Yang 0 0 Centers for Metabolic Disease Research, Cardiovascular Research, and Thrombosis Research, Department of Pharmacology, Temple University

Normalizing bead-based microRNA expression data: a measurement error model-based approach

Motivation: Compared with complementary DNA (cDNA) or messenger RNA (mRNA) microarray data, microRNA (miRNA) microarray data are harder to normalize due to the facts that the total number of miRNAs is small, and that the majority of miRNAs usually have low expression levels. In bead-based microarrays, the hybridization is completed in several pools. As a result, the number of...

Brain White Matter Shape Changes in Amyotrophic Lateral Sclerosis (ALS): A Fractal Dimension Study

Amyotrophic lateral sclerosis (ALS) is a fatal progressive neurodegenerative disorder. Current diagnosis time is about 12-months due to lack of objective methods. Previous brain white matter voxel based morphometry (VBM) studies in ALS reported inconsistent results. Fractal dimension (FD) has successfully been used to quantify brain WM shape complexity in various neurological...