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Low-dose capecitabine (Xeloda) for treatment for gastrointestinal cancer

The prodrug capecitabine (Xeloda) has been an important drug for treatment for gastrointestinal cancer (GI-cancer). This study explores the efficacy of continuous metronomic Xeloda, as well as tolerability and best response during treatment. Patients (n = 35) with stage IV GI-cancer were included in the study and were divided into two groups; upper (n = 13) and lower (n = 22) GI...

A clinical study of metastasized rectal cancer treatment: assessing a multimodal approach

Metastasized rectal cancer has long been considered incurable. During recent years, the treatment of rectal cancer patients has been improved, and nowadays, a subgroup of patients might even be cured. The aim of this study was to investigate the optimal timing of treatment in a multimodal therapy schedule in order to see whether the addition of bevacizumab (Avastin) to...

Space-and-Time Efficient Parallel Garbage Collector for Data-Intensive Applications

Shaoshan Liu Ligang Wang Xiao-Feng Li Jean-Luc Gaudiot As multithreaded server applications and runtime systems prevail, garbage collection is becoming an essential feature to support high

Achieving middleware execution efficiency: hardware-assisted garbage collection operations

Although virtualization technologies bring many benefits to cloud computing environments, as the virtual machines provide more features, the middleware layer has become bloated, introducing a high overhead. Our ultimate goal is to provide hardware-assisted solutions to improve the middleware performance in cloud computing environments. As a starting point, in this paper, we...

Dynamical properties of a mutualism system in the presence of noise and time delay

The normalized correlation function C(s) and the associated relaxation time Tc of the mutualism system in the presence of noise and time delay are investigated. The effects of noise and time delay on C(s) and Tc for a mutualism system are discussed. Based on the numerical computation, it is found that: (i) The noise intensity D slows down the the fluctuation decay of species...

Categorical perception of nonspeech chirps and bleats

Mattingly, Liberman, Syrdal, and Halwes, (1971) claimed to demonstrate that subjects cannot classify nonspeech chirp and bleat continua, but that they can classify into three categories a syllable place continuum whose variation is physically identical to the nonspeech chirp and bleat continua. This finding for F2 transitions, as well as similar findings for F3 transitions, has...