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Targeting mitochondrial reactive oxygen species as novel therapy for inflammatory diseases and cancers

Xiao-feng Yang 0 0 Cardiovascular Research Center, Department of Pharmacology and Thrombosis Research Center, Temple University School of Medicine , 3500 North Broad Street, Philadelphia, PA 19140 , USA

Targeting mitochondrial reactive oxygen species as novel therapy for inflammatory diseases and cancers

Xiao-feng Yang 0 0 Cardiovascular Research Center, Department of Pharmacology and Thrombosis Research Center, Temple University School of Medicine , 3500 North Broad Street, Philadelphia, PA 19140 , USA

Targeting mitochondrial reactive oxygen species as novel therapy for inflammatory diseases and cancers

Xiao-feng Yang 0 0 Cardiovascular Research Center, Department of Pharmacology and Thrombosis Research Center, Temple University School of Medicine , 3500 North Broad Street, Philadelphia, PA 19140 , USA

Targeting mitochondrial reactive oxygen species as novel therapy for inflammatory diseases and cancers

Xiao-feng Yang 0 0 Cardiovascular Research Center, Department of Pharmacology and Thrombosis Research Center, Temple University School of Medicine , 3500 North Broad Street, Philadelphia, PA 19140 , USA

Immunosuppressive/anti-inflammatory cytokines directly and indirectly inhibit endothelial dysfunction- a novel mechanism for maintaining vascular function

Endothelial dysfunction is a pathological status of the vascular system, which can be broadly defined as an imbalance between endothelium-dependent vasoconstriction and vasodilation. Endothelial dysfunction is a key event in the progression of many pathological processes including atherosclerosis, type II diabetes and hypertension. Previous reports have demonstrated that pro...

Analyses of caspase-1-regulated transcriptomes in various tissues lead to identification of novel IL-1β-, IL-18- and sirtuin-1-independent pathways

and Xiao-feng Yang1, 2, 3, 4Email authorView ORCID ID profile †Contributed equally Journal of Hematology & Oncology201710:40 https://doi.org/10.1186/s13045-017-0406-2 ©  The Author(s). 2017

MicroRNAs and Toll-like Receptor/Interleukin-1 Receptor Signaling

The discovery of miRNAs has revolutionized the way we examine the genome, RNA products, and the regulation of transcription and translation. Their ability to modulate protein expression through mRNA degradation and translation repression resulted in avid scientific interest in miRNAs over the past decade. This research has led to findings that indicate miRNAs can regulate an...

ATP directed agent, 8-chloro-adenosine, induces AMP activated protein kinase activity, leading to autophagic cell death in breast cancer cells

Background 8-chloro-adenosine (8-Cl-Ado) is a unique ribonucleoside analog which is currently in a phase I clinical trial for hematological malignancies. Previously, we demonstrated in breast cancer cells that a 3-day treatment with 10 μM 8-Cl-Ado causes a 90% loss of clonogenic survival. In contrast, there was only a modest induction of apoptosis under these conditions...

ATP directed agent, 8-chloro-adenosine, induces AMP activated protein kinase activity, leading to autophagic cell death in breast cancer cells

, 2Email author, Hima V Vangapandu1, 2, Xiao-Feng Le1, Weiqun Mao1 and Shujun Shentu1 Journal of Hematology & Oncology20147:23 https://doi.org/10.1186/1756-8722-7-23 ©  Stellrecht et al.; licensee

An evolving new paradigm: endothelial cells – conditional innate immune cells

Endothelial cells (ECs) are a heterogeneous population that fulfills many physiological processes. ECs also actively participate in both innate and adaptive immune responses. ECs are one of the first cell types to detect foreign pathogens and endogenous metabolite-related danger signals in the bloodstream, in which ECs function as danger signal sensors. Treatment with...

Targeting mitochondrial reactive oxygen species as novel therapy for inflammatory diseases and cancers

Xiao-feng Yang 0 0 Cardiovascular Research Center, Department of Pharmacology and Thrombosis Research Center, Temple University School of Medicine , 3500 North Broad Street, Philadelphia, PA 19140 , USA

Endothelial progenitor cells in ischemic stroke: an exploration from hypothesis to therapy

Chernaya Sonia Samuel Su-Xuan Liu 0 Hong Wang 0 Xiao-Feng Yang 0 0 Centers for Metabolic Disease Research, Cardiovascular Research, and Thrombosis Research, Department of Pharmacology, Temple University