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CD146: a potential therapeutic target for systemic sclerosis

, Xiaofeng Zeng and Xiyun Yan designed the experiments. Lingling Zhang, Yongting Luo, Xiao Teng, Zhenzhen Wu and Fei Wang performed all the experiments, analyzed and interpreted the data, Mengtao Li, Dong Xu ... , Xiao Teng, Zhenzhen Wu, Mengtao Li, Dong Xu, Qian Wang, Fei Wang, Jing Feng, Xiaofeng Zeng and Xiyun Yan declare that they have no conflict of interest. All procedures followed were in accordance with

Arabidopsis ERF1 Mediates Cross-Talk between Ethylene and Auxin Biosynthesis during Primary Root Elongation by Regulating ASA1 Expression

The gaseous phytohormone ethylene participates in the regulation of root growth and development in Arabidopsis. It is known that root growth inhibition by ethylene involves auxin, which is partially mediated by the action of the WEAK ETHYLENE INSENSITIVE2/ANTHRANILATE SYNTHASE α1 (WEI2/ASA1), encoding a rate-limiting enzyme in tryptophan (Trp) biosynthesis, from which auxin is...

Deciphering the Draft Genome of Toxoplasma gondii RH Strain

Toxoplasmosis is a widespread parasitic infection by Toxoplasma gondii, a parasite with at least three distinct clonal lineages. This article reports the whole genome sequencing and de novo assembly of T. gondii RH (type I representative strain), as well as genome-wide comparison across major T. gondii lineages. Genomic DNA was extracted from tachyzoites of T. gondii RH strain...

Automated biphasic morphological assessment of hepatitis B-related liver fibrosis using second harmonic generation microscopy

AuthorsSearch for Tong-Hong Wang in:Nature Research journals • PubMed • Google ScholarSearch for Tse-Ching Chen in:Nature Research journals • PubMed • Google ScholarSearch for Xiao Teng in:Nature Research

miR-7a/b attenuates post-myocardial infarction remodeling and protects H9c2 cardiomyoblast against hypoxia-induced apoptosis involving Sp1 and PARP-1

miRs (microRNAs, miRNAs) intricately regulate physiological and pathological processes. Although miR-7a/b protects against cardiomyocyte injury in ischemia/reperfusion injury, the function of miR-7a/b in myocardial infarction (MI)-induced cardiac remodeling remains unclear. Here, we sought to investigate the function of miR-7a/b in post-MI remodeling in a mouse model and to...

Donor-derived exosomes induce specific regulatory T cells to suppress immune inflammation in the allograft heart

, ChinaJiangping Song, Jie Huang, Xiao Chen, Xiao Teng, Zhizhao Song, Yong Xing, Mangyuan Wang, Kai Chen, Zheng Wang, Pingchang Yang & Shengshou Hu AuthorsSearch for Jiangping Song in:Nature Research journals ... • PubMed • Google ScholarSearch for Jie Huang in:Nature Research journals • PubMed • Google ScholarSearch for Xiao Chen in:Nature Research journals • PubMed • Google ScholarSearch for Xiao Teng in:Nature

HDG11 upregulates cell-wall-loosening protein genes to promote root elongation in Arabidopsis

The gain-of-function mutant edt1 shows significantly enhanced drought tolerance and a well-developed root system including deeper primary roots and more lateral roots. To explore the molecular mechanisms underlying the improved root system of edt1, we performed transcriptome comparison between the wild-type and edt1 roots. One of the interesting findings from the analysis was...

Impact Behavior of Recycled Aggregate Concrete Based on Split Hopkinson Pressure Bar Tests

This paper presents the experimental results of recycled aggregate concrete (RAC) specimens prepared with five different amounts of recycled coarse aggregate (RCA) (i.e., 0, 25%, 50%, 75%, and 100%) subjected to impact loading based on split Hopkinson pressure bar tests. Strain-rate effects on dynamic compressive strength and critical strain of RAC were studied. Results show that...

A Polymorphism in Hepatocyte Nuclear Factor 1 Alpha, rs7310409, Is Associated with Left Main Coronary Artery Disease

Coronary artery disease is the leading cause of mortality and morbidity in the world. Left main coronary artery disease (LMCAD) is a particularly severe phenotypic form of CAD and has a genetic basis. We hypothesized that some inflammation- and hyperhomocysteinemia-related gene polymorphisms may contribute to LMCAD susceptibility in a Chinese population. We studied the...

MADS-Box Transcription Factor AGL21 Regulates Lateral Root Development and Responds to Multiple External and Physiological Signals

Plant root system morphology is dramatically influenced by various environmental cues. The adaptation of root system architecture to environmental constraints, which mostly depends on the formation and growth of lateral roots, is an important agronomic trait. Lateral root development is regulated by the external signals coordinating closely with intrinsic signaling pathways. MADS...

The evaluation of the association between the metabolic syndrome and tumor grade and stage of bladder cancer in a Chinese population

Xie,3 Lin-Guo Xie,1,2 Yu Zhang,1,2 Chen Xing,1,2 Xiao-teng Liu,1,2 Zhong-Hua Shen,1,2 Zhou-Liang Wu,1,2 Hai-Long Hu1,2 Chang-Li Wu1,2 1Department of Urology, The Second Hospital of Tianjin Medical