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Activin a promotes myofibroblast differentiation of endometrial mesenchymal stem cells via STAT3-dependent Smad/CTGF pathway

Endometriosis, characterized by the presence of functional endometrial tissues outside the uterus, is one of the most common gynecological disorders. Endometrial mesenchymal stem cells (MSCs) are crucial for the occurrence and development of endometriosis. Ectopic endometrial MSCs exist in the peritoneal cavity. Thus, the bioactive factors in endometriotic peritoneal fluid may...

TFE3 fusions escape from controlling of mTOR signaling pathway and accumulate in the nucleus promoting genes expression in Xp11.2 translocation renal cell carcinomas

Xp11.2 translocation renal cell carcinoma (tRCC) is mainly caused by translocation of the TFE3 gene located on chromosome Xp11.2 and is characterized by overexpression of the TFE3 fusion gene. Patients are diagnosed with tRCC usually before 45 years of age with poor prognosis. We investigated this disease using two tRCC cell lines, UOK109 and UOK120, in this study. The purpose of...

Velocity and attenuation of elastic wave in a developed layer with the initial inner percolation in the pores

An improved model based on Biot poroelastic theory is presented incorporating the initial seepage flow in the matrix. The proposed model quantifies wave propagation in the oil field development process as VSP, transient well tests, and seismic production technology. Porosity variation, fluid–solid compressibility, and pseudo-threshold pressure gradient in low permeability...

Macrophage Functions and Regulation: Roles in Diseases and Implications in Therapeutics

research on macrophage functions and development of selective and efficient therapeutics. Kebin Hu Yang Jin Zissis Chroneos Xiaodong Han Hao Liu Ling Lin References F. Geissmann, M. G. Manz, S. Jung, M

The hedgehog and Wnt/β-catenin system machinery mediate myofibroblast differentiation of LR-MSCs in pulmonary fibrogenesis

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and fatal lung disease that is characterized by enhanced changes in stem cell differentiation and fibroblast proliferation. Resident mesenchymal stem cells (LR-MSCs) can undergo phenotype conversion to myofibroblasts to augment extracellular matrix production, impairing function and contributing to pulmonary fibrosis...

Strain Gradient Modulated Exciton Evolution and Emission in ZnO Fibers

• Google ScholarSearch for Xiaodong Han in:Nature Research journals • PubMed • Google Scholar Contributions X.H., Y.J. and Z.Z. conceived the ideas and supervised the work. B.W. prepared the TEM and SEM ... financial interests. Corresponding authors Correspondence to Yuan Ji or Xiaodong Han. Supplementary information Word documents1.Supplementary Information Rights and permissions This work is

New twinning route in face-centered cubic nanocrystalline metals

Search for Xiaodong Han in:Nature Research journals • PubMed • Google Scholar Contributions L.W. and P.G. contributed equally to this work. X.H., Z.Z., and M.C. designed the project and guided the ... discussions of the results. Competing interests The authors declare no competing financial interests. Corresponding authors Correspondence to Ting Zhu or Mingwei Chen or Xiaodong Han. Electronic

Direct realizing the growth direction of epitaxial nanowires by electron microscopy

Zou’s group at the University of Queensland as a PhD student in 2012. His research focuses on the investigation of structural characteristics of III-V nanowires through electron microscopy. Xiaodong Han

Mesenchymal stromal cell treatment prevents H9N2 avian influenza virus-induced acute lung injury in mice

BackgroundThe avian influenza virus (AIV) can cross species barriers and expand its host range from birds to mammals, even humans. Avian influenza is characterized by pronounced activation of the proinflammatory cytokine cascade, which perpetuates the inflammatory response, leading to persistent systemic inflammatory response syndrome and pulmonary infection in animals and humans...

Mesenchymal stromal cell treatment prevents H9N2 avian influenza virus-induced acute lung injury in mice

The avian influenza virus (AIV) can cross species barriers and expand its host range from birds to mammals, even humans. Avian influenza is characterized by pronounced activation of the proinflammatory cytokine cascade, which perpetuates the inflammatory response, leading to persistent systemic inflammatory response syndrome and pulmonary infection in animals and humans. There...

miR-877-3p targets Smad7 and is associated with myofibroblast differentiation and bleomycin-induced lung fibrosis

in:Nature Research journals • PubMed • Google ScholarSearch for Kebin Hu in:Nature Research journals • PubMed • Google ScholarSearch for Xiaodong Han in:Nature Research journals • PubMed • Google Scholar ... experiments. Competing interests The authors declare no competing financial interests. Corresponding author Correspondence to Xiaodong Han. Supplementary information PDF files1.Supplementary Information

Effects of Bariatric Surgery on Renal Function in Obese Patients: A Systematic Review and Meta Analysis

Background Obesity is an independent risk factor of development and progression of chronic kidney disease (CKD). Data on the benefits of bariatric surgery in obese patients with impaired kidney function have been conflicting. Objective To explore whether there is improvement in glomerular filtration rate (GFR), proteinuria or albuminuria after bariatric surgery. Methods We...

Dislocation “Bubble-Like-Effect” and the Ambient Temperature Super-plastic Elongation of Body-centred Cubic Single Crystalline Molybdenum

Deng in:Nature Research journals • PubMed • Google ScholarSearch for Ze Zhang in:Nature Research journals • PubMed • Google ScholarSearch for Xiaodong Han in:Nature Research journals • PubMed • Google ... to Lihua Wang or Xiaodong Han. Supplementary information PDF files1.Supplementary Information Rights and permissions This work is licensed under a Creative Commons Attribution 4.0

Growth of III-V semiconductor nanowires and their heterostructures

In this paper, we present a review about recent progress on the growth of III-V semiconductor homo- and heterostructured nanowires. We will first deliver a general discussion on the crystal structure and the conventional growth mechanism of one dimensional nanowires. Then we provide a review about most widely used growth techniques, sample preparation and the cutting edge...

Effects of a Moderately Lower Temperature on the Proliferation and Degranulation of Rat Mast Cells

equally to this work. Dongmei Li, Zou Xiang, and Xiaodong Han contributed to conception and design of the experiments. Ruoyu Wang, Dongmei Li, Xiaoqin Yin, Zou Xiang, Hui Zhang, Jiwei Wang, Lin Chen, and

The Short-Term Remission of Diabetic Nephropathy After Roux-en-Y Gastric Bypass in Chinese Patients of T2DM with Obesity

The study aimed to examine the effect of gastric bypass on diabetic nephropathy (DN) in Chinese patients. A retrospective study of 101 samples with DN stages I to IV underwent Roux-en-Y gastric bypass. Anthropometric and biochemical parameters were assessed during a 1-year follow-up. Binary logistic regression analysis was used for predictors and ROC for cutoff points. There was...

A Hybrid Analytical/Numerical Model for the Characterization of Preferential Flow Path with Non-Darcy Flow

Due to the long-term fluid-solid interactions in waterflooding, the tremendous variation of oil reservoir formation parameters will lead to the widespread evolution of preferential flow paths, thereby preventing the further enhancement of recovery efficiency because of unstable fingering and premature breakthrough. To improve oil recovery, the characterization of preferential...

Effect of Laparoscopic Roux-en-Y Gastric Bypass Surgery on Obstructive Sleep Apnea in a Chinese Population with Obesity and T2DM

BackgroundBariatric surgery has been reported to be an effective treatment for obstructive sleep apnea (OSA). However, this evidence was not enough for different populations. Thus, we conducted a follow-up study to evaluate the effect of bariatric surgery on OSA in a Chinese population with obesity and type 2 diabetes mellitus (T2DM).MethodsFrom May 2011 to March 2014, 72...

Antagonistic Effects of a Mixture of Low-Dose Nonylphenol and Di-N-Butyl Phthalate (Monobutyl Phthalate) on the Sertoli Cells and Serum Reproductive Hormones in Prepubertal Male Rats In Vitro and In Vivo

The estrogenic chemical nonylphenol (NP) and the antiandrogenic agent di-n-butyl phthalate (DBP) are regarded as widespread environmental endocrine disruptors (EDCs) which at high doses in some species of laboratory animals, such as mice and rats, have adverse effects on male reproduction and development. Given the ubiquitous coexistence of various classes of EDCs in the...

A biopolymer-like metal enabled hybrid material with exceptional mechanical prowess

Xiaodong Han in:Nature Research journals • PubMed • Google ScholarSearch for Zhenyang Liu in:Nature Research journals • PubMed • Google ScholarSearch for Yunzhi Wang in:Nature Research journals • PubMed