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Search: authors:"Xiaodong Lu"

7 papers found.
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Nonlinear Disturbance Observer-Based Adaptive Sliding Mode Control for a Generic Hypersonic Vehicle

In this paper, a new adaptive sliding mode control method is presented for the longitudinal model of a generic hypersonic vehicle subject to uncertainties and external disturbance. Firstly, an oriented-control model with mismatched uncertainties is built for a generic hypersonic vehicle. Secondly, the back-stepping technique is introduced to design a sliding mode controller with...

Nonlinear Disturbance Observer-Based Adaptive Sliding Mode Control for a Generic Hypersonic Vehicle

In this paper, a new adaptive sliding mode control method is presented for the longitudinal model of a generic hypersonic vehicle subject to uncertainties and external disturbance. Firstly, an oriented-control model with mismatched uncertainties is built for a generic hypersonic vehicle. Secondly, the back-stepping technique is introduced to design a sliding mode controller with...

Common and cell-type specific responses to anti-cancer drugs revealed by high throughput transcript profiling

Research journals • PubMed • Google Scholar Search for Mirra Chung in:Nature Research journals • PubMed • Google Scholar Search for Xiaodong Lu in:Nature Research journals • PubMed • Google Scholar Search

The role of anti-aquaporin 4 antibody in the conversion of acute brainstem syndrome to neuromyelitis optica

Background Acute brainstem syndrome (ABS) may herald multiple sclerosis (MS), neuromyelitis optica (NMO), or occur as an isolated syndrome. The aquaporin 4 (AQP4)-specific serum autoantibody, NMO-IgG, is a biomarker for NMO. However, the role of anti-AQP4 antibody in the conversion of ABS to NMO is unclear. Methods Thirty-one patients with first-event ABS were divided into two...

Multiple P-TEFbs cooperatively regulate the release of promoter-proximally paused RNA polymerase II

The association of DSIF and NELF with initiated RNA Polymerase II (Pol II) is the general mechanism for inducing promoter-proximal pausing of Pol II. However, it remains largely unclear how the paused Pol II is released in response to stimulation. Here, we show that the release of the paused Pol II is cooperatively regulated by multiple P-TEFbs which are recruited by bromodomain...

Dimeric structure of p300/CBP associated factor

Background p300/CBP associating factor (PCAF, also known as KAT2B for lysine acetyltransferase 2B) is a catalytic subunit of megadalton metazoan complex ATAC (Ada-Two-A containing complex) for acetylation of histones. However, relatively little is known about the regulation of the enzymatic activity of PCAF. Results Here we present two dimeric structures of the PCAF...

Signal-induced Brd4 release from chromatin is essential for its role transition from chromatin targeting to transcriptional regulation

Bromodomain-containing protein Brd4 is shown to persistently associate with chromosomes during mitosis for transmitting epigenetic memory across cell divisions. During interphase, Brd4 also plays a key role in regulating the transcription of signal-inducible genes by recruiting positive transcription elongation factor b (P-TEFb) to promoters. How the chromatin-bound Brd4 transits...