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Osthole inhibits gastric cancer cell proliferation through regulation of PI3K/AKT

project of Jiangsu province under Grant QNRC2016166 and Doctor Fund of Wuxi Health Bureau under Grant 2014BS01. Author Contributions Conceptualization: Yan Zhang. Data curation: Xiaojun Xu, Yan Zhang ... . Formal analysis: Xiaoyuan Liu, Yan Zhang. Funding acquisition: Yan Zhang. Methodology: Xiaojun Xu, Yan Zhang. Project administration: Yan Zhang. Resources: Yan Zhang. 8 / 10 Software: Xiaoyuan Liu, Yan

hTAC internalizes via both clathrin-dependent and clathrin-independent endocytosis in mammalian cells

(2011087). Xinyu Zhu, Min Li, Xiaojun Xu, Rui Zhang, Xiaofei Zhang, Zhuo Ma, Jingze Lu, Tao Xu, Junjie Hou and Eli Song declare that they have no conflict of interest. This article does not contain any ... source, provide a link to the Creative Commons license, and indicate if changes were made. i t Xinyu Zhu, Min Li and Xiaojun Xu have contributed equally to this work. Electronic supplementary material The

CRISPR-Cas9 cleavage efficiency correlates strongly with target-sgRNA folding stability: from physical mechanism to off-target assessment

The CRISPR/Cas9 complex, a bacterial immune response system, has been widely adopted for RNA-guided genome editing and transcription regulation in applications such as targeted genome modification and site-directed mutagenesis. However, the physical basis for its target specificity is not fully understood. In this study, based on a statistical mechanical analysis for the whole...

VfoldCPX Server: Predicting RNA-RNA Complex Structure and Stability

RNA-RNA interactions are essential for genomic RNA dimerization, mRNA splicing, and many RNA-related gene expression and regulation processes. The prediction of the structure and folding stability of RNA-RNA complexes is a problem of significant biological importance and receives substantial interest in the biological community. The VfoldCPX server provides a new web interface to...

Physics-based RNA structure prediction

Despite the success of RNA secondary structure prediction for simple, short RNAs, the problem of predicting RNAs with long-range tertiary folds remains. Furthermore, RNA 3D structure prediction is hampered by the lack of the knowledge about the tertiary contacts and their thermodynamic parameters. Low-resolution structural modeling enables us to estimate the conformational...

Modeling the functional state of the reverse transcriptase of hepatitis B virus and its application to probing drug-protein interaction

Background Herein, the predicted atomic structures of five representative sequence variants of the reverse transcriptase protein (RT) of hepatitis B virus (HBV), sampled from patients with rapid or slow response to tenofovir disoproxil fumarate (TDF) treatment, have been examined to identify structural variations between them in order to assess structural and functional...

Improving Estimations of Spatial Distribution of Soil Respiration Using the Bayesian Maximum Entropy Algorithm and Soil Temperature as Auxiliary Data

Soil respiration inherently shows strong spatial variability. It is difficult to obtain an accurate characterization of soil respiration with an insufficient number of monitoring points. However, it is expensive and cumbersome to deploy many sensors. To solve this problem, we proposed employing the Bayesian Maximum Entropy (BME) algorithm, using soil temperature as auxiliary...

Vfold: A Web Server for RNA Structure and Folding Thermodynamics Prediction

Background The ever increasing discovery of non-coding RNAs leads to unprecedented demand for the accurate modeling of RNA folding, including the predictions of two-dimensional (base pair) and three-dimensional all-atom structures and folding stabilities. Accurate modeling of RNA structure and stability has far-reaching impact on our understanding of RNA functions in human health...

Opening pathways of the DNA clamps proliferating cell nuclear antigen and Rad9-Rad1-Hus1

Proliferating cell nuclear antigen and the checkpoint clamp Rad9-Rad1-Hus1 topologically encircle DNA and act as mobile platforms in the recruitment of proteins involved in DNA damage response and cell cycle regulation. To fulfill these vital cellular functions, both clamps need to be opened and loaded onto DNA by a clamp loader complex—a process, which involves disruption of the...

Functional Impact of 14 Single Nucleotide Polymorphisms Causing Missense Mutations of Human α7 Nicotinic Receptor

The α7nicotinic receptor (nAChR) is a major subtype of the nAChRs in the central nervous system, and the receptor plays an important role in brain function. In the dbSNP database, there are 55 single nucleotide polymorphisms (SNPs) that cause missense mutations of the human α7nAChR in the coding region. In this study, we tested the impact of 14 SNPs that cause missense mutations...

Altered activation in visual cortex: Unusual functional magnetic resonance imaging finding in early Parkinson’s disease

Objective Movement dysfunction in Parkinson’s disease (PD) is well documented but its cause remains unclear. This study examined whether motor symptoms are caused by sensory impairment, executive dysfunction or other factors.

The diminishing socioeconomic disparity in obesity in a Chinese population with rapid economic development: analysis of serial cross-sectional health survey data 2002–2010

Background Social changes and economic development are associated with obesity epidemic. This study is to investigate the trends of socio-economic disparity in obesity from 2002 to 2010 in a Chinese population experiencing the world’s fastest economic development. Methods Four standardized surveys were conducted in a population of 85 million residents in Guangdong, China between...

Direct evidence for kinetic effects associated with solar wind reconnection

Wang, Fengsi Wei & Xueshang FengFaculty of Information Technology, Macau University of Science and Technology, Macao, ChinaHon-Cheng Wong AuthorsSearch for Xiaojun Xu in:Nature Research journals • PubMed ... the paper. Competing interests The authors declare no competing financial interests. Corresponding authors Correspondence to Xiaojun Xu or Hon-Cheng Wong. Rights and permissions This work is

Chemoprevention of dietary digitoflavone on colitis-associated colon tumorigenesis through inducing Nrf2 signaling pathway and inhibition of inflammation

Background Nuclear factor-erythroid 2-related factor 2 (Nrf2) has emerged as a novel target for the prevention of colorectal cancer (CRC). Many chemopreventive compounds associated with Nrf2 activation are effective in preclinical systems and many on-going clinical trials are showing promising findings. In present study we evaluated the cytoprotective effect and chemopreventive...

Automatic Classification of Early Parkinson's Disease with Multi-Modal MR Imaging

Background In recent years, neuroimaging has been increasingly used as an objective method for the diagnosis of Parkinson's disease (PD). Most previous studies were based on invasive imaging modalities or on a single modality which was not an ideal diagnostic tool. In this study, we developed a non-invasive technology intended for use in the diagnosis of early PD by integrating...

Large Daily Stock Variation Is Associated with Cardiovascular Mortality in Two Cities of Guangdong, China

Objective The current study aimed to examine the effects of daily change of the Shenzhen Stock Exchange Index on cardiovascular mortality in Guangzhou and Taishan, China. Methods Daily mortality and stock performance data during 2006–2010 were collected to construct the time series for the two cities. A distributed lag non-linear model was utilized to examine the effect of daily...

Probing DNA clamps with single-molecule force spectroscopy

Detailed mechanisms of DNA clamps in prokaryotic and eukaryotic systems were investigated by probing their mechanics with single-molecule force spectroscopy. Specifically, the mechanical forces required for the Escherichia coli and Saccharomyces cerevisiae clamp opening were measured at the single-molecule level by optical tweezers. Steered molecular dynamics simulations further...

Temperature Changes between Neighboring Days and Mortality in Summer: A Distributed Lag Non-Linear Time Series Analysis

Background Many studies have shown that high temperatures or heat waves were associated with mortality and morbidity. However, few studies have examined whether temperature changes between neighboring days have any significant impact on human health. Method A distributed lag non-linear model was employed to investigate the effect of temperature changes on mortality in summer...

Lagged Effect of Diurnal Temperature Range on Mortality in a Subtropical Megacity of China

Background Many studies have found extreme temperature can increase the risk of mortality. However, it is not clear whether extreme diurnal temperature range (DTR) is associated with daily disease-specific mortality, and how season might modify any association. Objectives To better understand the acute effect of DTR on mortality and identify whether season is a modifier of the...