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Identification of potentially cytotoxic lesions induced by UVA photoactivation of DNA 4-thiothymidine in human cells

Photochemotherapy—in which a photosensitizing drug is combined with ultraviolet or visible radiation—has proven therapeutic effectiveness. Existing approaches have drawbacks, however, and there is a clinical need to develop alternatives offering improved target cell selectivity. DNA substitution by 4-thiothymidine (S4TdR) sensitizes cells to killing by ultraviolet A (UVA...

Guanine sulphinate is a major stable product of photochemical oxidation of DNA 6-thioguanine by UVA irradiation

The DNA of patients taking the immunosuppressant and anticancer drugs azathioprine or 6-mercaptopurine contains 6-thioguanine (6-TG). The skin of these patients is selectively sensitive to ultraviolet A radiation (UVA) and they suffer an extremely high incidence of sunlight-induced skin cancer with long-term treatment. DNA 6-TG interacts with UVA to generate reactive oxygen...

A Novel Speech/Noise Discrimination Method for Embedded ASR System

environments, adaptive speech signal processing, and multimedia system. He is now working with researchers and engineers at Motorola on the applications of speech recognition on embedded mobile devices . Xiaolin ... Ren was born in 1973 in Zhejiang, China. He received his B.S. degree in 1994 in electronic engineering from Zhejiang University at Xiqi, Hangzhou, China, M.S. degree in 1997 in communications and