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Low expression of SPARC in gastric cancer-associated fibroblasts leads to stemness transformation and 5-fluorouracil resistance in gastric cancer

The aim of the present study was to clarify the correlations between SPARC expression in gastric cancer-associated fibroblasts (GCAFs) and the prognosis of patients with gastric cancer and to elucidate the role of GCAF-derived SPARC in stemness transformation and 5-fluorouracil resistance in gastric cancer. One hundred ninety-two patients were enrolled in the present study. SPARC...

CRISPR/Cas9-mediated gene knockout reveals a guardian role of NF-κB/RelA in maintaining the homeostasis of human vascular cells

Xiaoqian Zhang have contributed equally to this work. inflammation, survival, vasculogenesis, cell differentiation and extracellular matrix organization in a cell typespecific manner under basal condition ... ; VCAM1, vascular cell adhesion molecule 1; VECs, vascular endothelial cells; VSMCs, vascular smooth muscle cells; WT, wildtype. COMPLIANCE WITH ETHICS GUIDELINES Ping Wang, Zunpeng Liu, Xiaoqian Zhang

Greenberger-Horne-Zeilinger states-based blind quantum computation with entanglement concentration

In blind quantum computation (BQC) protocol, the quantum computability of servers are complicated and powerful, while the clients are not. It is still a challenge for clients to delegate quantum computation to servers and keep the clients’ inputs, outputs and algorithms private. Unfortunately, quantum channel noise is unavoidable in the practical transmission. In this paper, a...

Longitudinal single-cell RNA sequencing of patient-derived primary cells reveals drug-induced infidelity in stem cell hierarchy

Chemo-resistance is one of the major causes of cancer-related deaths. Here we used single-cell transcriptomics to investigate divergent modes of chemo-resistance in tumor cells. We observed that higher degree of phenotypic intra-tumor heterogeneity (ITH) favors selection of pre-existing drug-resistant cells, whereas phenotypically homogeneous cells engage covert epigenetic...

PADI2 gene confers susceptibility to breast cancer and plays tumorigenic role via ACSL4, BINC3 and CA9 signaling

Background Peptidylarginine deiminase (PAD) post-translationally converts arginine residues to citrulline residues. Recent studies have suggested that PADI2 (PAD isoform 2), a member of the PAD family, is involved in the tumorigenic process of some tumors, especially breast cancer. However, little is known about the mechanisms of PADI2 in tumorigenesis. This study aimed to...

Efficacy of statins in patients with diabetic nephropathy: a meta-analysis of randomized controlled trials

Background The effects of statins in patients with diabetic nephropathy are controversial. With increasing interest in the potential therapeutic role of statins in diabetic nephropathy, it is essential to evaluate its real effects. Methods PubMed, EMBASE, Web of Science databases, Cochrane Central Register of Controlled Trials and China National Knowledge Infrastructure were...

Dual inhibiting OCT4 and AKT potently suppresses the propagation of human cancer cells

AKT serves as an epigenetic modulator that links epigenetic regulation to cell survival and proliferation while the epigenetic mediator OCT4 critically controls stem cell pluripotency and self-renewal. Emerging evidence indicated their complicated interplays in cancer cells and cancer stem cells (CSCs), and inhibiting either one may activate the other. Thus, in this study, we...

A New Fluidized Bed Bioreactor Based on Diversion-Type Microcapsule Suspension for Bioartificial Liver Systems

A fluidized bed bioreactor containing encapsulated hepatocytes may be a valuable alternative to a hollow fiber bioreactor for achieving the improved mass transfer and scale-up potential necessary for clinical use. However, a conventional fluidized bed bioreactor (FBB) operating under high perfusion velocity is incapable of providing the desired performance due to the resulting...

Determination of Morphine and Codeine in Human Urine by Gas Chromatography-Mass Spectrometry

: Jianxiu Du Copyright © 2013 Xiaoqian Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction

An oncogenic role of Agrin in regulating focal adhesion integrity in hepatocellular carcinoma

, Jianxiang Chen, Xiaoqian Zhang, Yan Shan Ong, Li Shen Loo, Semih Can Akıncılar, Jayantha Gunaratne, Vinay Tergaonkar, Kam M. Hui & Wanjin HongLaboratory of Cancer Genomics, Cellular and Molecular Research ... Research journals • PubMed • Google ScholarSearch for Xiaoqian Zhang in:Nature Research journals • PubMed • Google ScholarSearch for Yan Shan Ong in:Nature Research journals • PubMed • Google ScholarSearch

TAZ Expression as a Prognostic Indicator in Colorectal Cancer

The Hippo pathway restricts the activity of transcriptional coactivators TAZ (WWTR1) and YAP. TAZ and YAP are reported to be overexpressed in various cancers, however, their prognostic significance in colorectal cancers remains unstudied. The expression levels of TAZ and YAP, and their downstream transcriptional targets, AXL and CTGF, were extracted from two independent colon...

Tryptophan derivatives regulate the transcription of Oct4 in stem-like cancer cells

The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor that responds to environmental toxicants, is increasingly recognized as a key player in embryogenesis and tumorigenesis. Here we show that a variety of tryptophan derivatives that act as endogenous AhR ligands can affect the transcription level of the master pluripotency factor Oct4. Among them, ITE...

Estrogen Effects on Candida albicans: A Potential Virulence-Regulating Mechanism

Three Candida albicans strains were tested in the presence of 17-β-estradiol (10−6 M and 10−9 M) for increased growth and for enhanced survival during incubation at nonpermissive temperatures. All 3 test organisms showed increased growth in the presence of estradiol compared with estrogen-free controls. Likewise, all 3 strains, when treated with estradiol, survived incubation at...