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CD-MEKC method to analyze triterpene acids in traditional chinese medicines

A cyclodextrin-modified micellar electrokinetic chromatographic (CD-MEKC) method was developed to separate and determine betulinic acid (BA), oleanolic acid (OA) and ursolic acid (UA) in traditional Chinese medicines (TCMs). Three pentacyclic triterpene acids were baseline seperated in the buffer (pH 9.0) of 6% (v/v) methanol containing 10 mmol L-1 disodium tetraborate, 10 mmol L...

ENANTIOSELECTIVE EXTRACTION OF RACEMIC OFLOXACIN BY DI(2-ETHYLHEXYL)PHOSPHORIC ACID AND TARTARIC ACID DERIVATIVES AS MIXED COMPLEX CHIRAL SELECTORS

CHIRAL SELECTORS   LINGXING TIAN, WEIJIE YANG, XIAOQING CHEN, YIXI XIE School of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China. Dirección para correspondencia ... , G. Bicker, N. Grinberg, Anal. Chem. 69, 1999, (1997)        [ Links ] (Received: November 23, 2009 - Accepted: April 15, 2011). Corresponding author: Prof. Xiaoqing Chen. e-mail:

Excellent combination of HPLC-RSD-DAD-ESI/MS and HSCCC experiments to screen and identify radical scavengers from Neo-Taraxacum siphonanthun

; Yuping Zhang; Xiaoqing Chen School of Chemistry and Chemical Engineering, Central South University, Changsha 410083, P.R. China     ABSTRACT Our previous research found that the crude extract of

The role of miR-431-5p in regulating pulmonary surfactant expression in vitro

BackgroundPulmonary surfactant is the complex mixture of lipid and protein that covers the alveolar surface. Pulmonary surfactant deficiency is one of the main causes of neonatal respiratory distress. Recent studies showed that miRNA plays an important role in lung development, but research into miR-431 regulation of pulmonary surfactant are sparse. In this study, we explored the...

The role of miR-431-5p in regulating pulmonary surfactant expression in vitro

Pulmonary surfactant is the complex mixture of lipid and protein that covers the alveolar surface. Pulmonary surfactant deficiency is one of the main causes of neonatal respiratory distress. Recent studies showed that miRNA plays an important role in lung development, but research into miR-431 regulation of pulmonary surfactant are sparse. In this study, we explored the...

Preparation of ZnO Photocatalyst for the Efficient and Rapid Photocatalytic Degradation of Azo Dyes

Zinc oxide (ZnO) photocatalysts were synthesized by sol–gel method using zinc acetate as precursor for degradation of azo dyes under UV irradiation. The resultant samples were characterized by different techniques, such as XRD, SEM, and EDX. The influence of preparation conditions such as calcination temperature and composite ratio on the degradation of methyl orange (MO) was...

The Influence of an EPS Concrete Buffer Layer Thickness on Debris Dams Impacted by Massive Stones in the Debris Flow

The failure of debris dams impacted by the massive stones in a debris flow represents a difficult design problem. Reasonable materials selection and structural design can effectively improve the resistance impact performance of debris dams. Based on the cushioning properties of expanded polystyrene (EPS) concrete, EPS concrete as a buffer layer poured on the surface of a rigid...

Eplerenone inhibits atrial fibrosis in mutant TGF-β1 transgenic mice

The purpose of the present study was to study the impacts of eplerenone (EPL), an antagonist of mineralocorticoid receptors (MR), on atrial fibrosis in a mouse model with selective fibrosis in the atrium, and to explore the possible mechanisms. Using mutant TGF-β1 transgenic (Tx) mice, we first demonstrated that EPL inhibited atrial fibrosis specifically and decreased macrophage...

Toll-Like Receptor 9 Inactivation Alleviated Atherosclerotic Progression and Inhibited Macrophage Polarized to M1 Phenotype in ApoE−/− Mice

Chen,3 Ye Lin,3 Weiping Hu,3 and Ling Lin3 1Cardiovascular Department, Second Affiliated Hospital and Second Clinical Medical College, Fujian Medical University, Quanzhou, Fujian 362000, China 2Key

Toll-Like Receptor 9 Inactivation Alleviated Atherosclerotic Progression and Inhibited Macrophage Polarized to M1 Phenotype in ApoE−/− Mice

Chen,3 Ye Lin,3 Weiping Hu,3 and Ling Lin3 1Cardiovascular Department, Second Affiliated Hospital and Second Clinical Medical College, Fujian Medical University, Quanzhou, Fujian 362000, China 2Key

Toll-Like Receptor 9 Inactivation Alleviated Atherosclerotic Progression and Inhibited Macrophage Polarized to M1 Phenotype in ApoE−/− Mice

Chen,3 Ye Lin,3 Weiping Hu,3 and Ling Lin3 1Cardiovascular Department, Second Affiliated Hospital and Second Clinical Medical College, Fujian Medical University, Quanzhou, Fujian 362000, China 2Key

Up-regulation of FoxN4 Expression in Adult Spinal Cord After Injury

Xiangdong Chen Yu Yao Junjie Guan Xiaoqing Chen Feng Zhang 0 ) Department of Spine Surgery, Affiliated Hospital of Nantong University , Nantong 226001, Jiangsu, People's Republic of China FoxN4

Effects of Pristane Alone or Combined with Chloroquine on Macrophage Activation, Oxidative Stress, and Th1/Th2 Skewness

We investigated the protective role of chloroquine against pristane-induced macrophage activation, oxidative stress, and Th1/Th2 skewness in C57BL/6J mice. Those mice were treated with pristane alone or combined with chloroquine. Hematological and biochemical parameters, macrophage phagocytic function, the oxidant/antioxidant index, cytokine for IFN-γ, TNF-α, IL-4, and IL-6, and...

Effects of Pristane Alone or Combined with Chloroquine on Macrophage Activation, Oxidative Stress, and Th1/Th2 Skewness

We investigated the protective role of chloroquine against pristane-induced macrophage activation, oxidative stress, and Th1/Th2 skewness in C57BL/6J mice. Those mice were treated with pristane alone or combined with chloroquine. Hematological and biochemical parameters, macrophage phagocytic function, the oxidant/antioxidant index, cytokine for IFN-γ, TNF-α, IL-4, and IL-6, and...

PCNA promotes processive DNA end resection by Exo1

Exo1-mediated resection of DNA double-strand break ends generates 3′ single-stranded DNA overhangs required for homology-based DNA repair and activation of the ATR-dependent checkpoint. Despite its critical importance in inducing the overall DNA damage response, the mechanisms and regulation of the Exo1 resection pathway remain incompletely understood. Here, we identify the ring...

Apigenin Inhibits Enterovirus-71 Infection by Disrupting Viral RNA Association with trans-Acting Factors

Flavonoids are widely distributed natural products with broad biological activities. Apigenin is a dietary flavonoid that has recently been demonstrated to interact with heterogeneous nuclear ribonucleoproteins (hnRNPs) and interferes with their RNA editing activity. We investigated whether apigenin possessed antiviral activity against enterovirus-71 (EV71) infection since EV71...

The inhibitory effect of small interference RNA protein kinase C-alpha on the experimental proliferative vitreoretinopathy induced by dispase in mice

Xiaoqing Chen,1 Wei Yang,1 Yongguang Yuan,1 Juan Tan,1 Yao Zong,1 Zhaoxin Jiang1 1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, People's Republic of

Role of Toll-Like Receptor 4 on Lupus Lung Injury and Atherosclerosis in LPS-Challenge ApoE−/− Mice

To investigate the pathologic mechanisms of toll-like receptor 4 (TLR4) in lung injury and atherosclerosis, ApoE−/− or wild-type mice were intraperitoneally administered saline, lipopolysaccharides (LPS), or LPS plus TAK-242 (TLR4 inhibitor), respectively, twice a week for 4 weeks. Serum autoantibody of antinuclear antibody (ANA), anti-double-stranded DNA (anti-dsDNA), and...

A Laboratory Evaluation of Medicinal Herbs Used in China for the Treatment of Hand, Foot, and Mouth Disease

Copyright © 2013 Xiaoqing Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium