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Genetic variants and haplotypes of the UGT1A9, 1A7 and 1A1 genes in Chinese Han

In this report, we describe combined polymorphisms of the UGT1A9, UGT1A7 and UGT1A1 genes in 100 unrelated, healthy Chinese Han subjects. The functional regions of these genes were sequenced and comprehensively analyzed for genetic polymorphisms. Thirty variants were detected, including five novel forms. Tentative functional predictions indicated that a Cys → Arg substitution at...

Government Reward-Penalty Mechanism in Closed-Loop Supply Chain Based on Dynamics Game Theory

; Revised 2 May 2018; Accepted 13 June 2018; Published 11 July 2018 Academic Editor: Seenith Sivasundaram Copyright © 2018 Xiaoqing Zhang et al. This is an open access article distributed under the

Coenzyme Q10 protects against hyperlipidemia-induced cardiac damage in apolipoprotein E-deficient mice

Hyperlipidemia is a well-established risk factor for cardiac damage, which can lead to cardiovascular diseases. Many studies have shown that Coenzyme Q10(CoQ10) protects against cardiac damage in vivo. The aim of this study was to investigate the possible protective effects of CoQ10 against cardiac damage in apolipoprotein E-deficient (ApoE−/−) mice. Eight-week-old male C57BL/6...

Risk factors for severe hypocalcemia after parathyroidectomy in dialysis patients with secondary hyperparathyroidism

Xiaoliang Sun in:Nature Research journals • PubMed • Google Scholar Search for Xiaoqing Zhang in:Nature Research journals • PubMed • Google Scholar Search for Yao Lu in:Nature Research journals • PubMed

Analysis of Soil-Compacting Effect Caused by Shield Tunneling Using Three-Dimensional Elastoplastic Solution of Cylindrical Cavity Expansion

Soil squeezing effect and formation disturbance caused by tunnel excavation can be simulated by cylindrical cavity expansion due to the comparability between tunneling and cavity expansion. Although most of the existing theoretical derivation is based on simple constitutive model of soil foundation, not only the relation between principal stress components was simplified in the...

Analysis of Soil-Compacting Effect Caused by Shield Tunneling Using Three-Dimensional Elastoplastic Solution of Cylindrical Cavity Expansion

Soil squeezing effect and formation disturbance caused by tunnel excavation can be simulated by cylindrical cavity expansion due to the comparability between tunneling and cavity expansion. Although most of the existing theoretical derivation is based on simple constitutive model of soil foundation, not only the relation between principal stress components was simplified in the...

Development and validation of the pulmonary tuberculosis scale of the system of Quality of Life Instruments for Chronic Diseases (QLICD-PT)

Generic assessments are less responsive to subtle changes due to specific diseases, making it challenging to fully understand the impact of pulmonary tuberculosis (TB) on patient’s quality of life (QOL). We applied programmed decision procedures and theories on instrument development to develop the scale. Two hundred patients with pulmonary TB participated in measuring QOL three...

A loss-of-function mutation p.T52S in RIPPLY3 is a potential predisposing genetic risk factor for Chinese Han conotruncal heart defect patients without the 22q11.2 deletion/duplication

Conotruncal heart defect (CTD) is a complex congenital heart disease with a complex and poorly understood etiology. The transcriptional corepressor RIPPLY3 plays a pivotal role in heart development as a negative regulator of the key cardiac transcription factor TBX1. A previous study showed that RIPPLY3 contribute to cardiac outflow tract development in mice, however, the...

MiR-137 inhibited cell proliferation and migration of vascular smooth muscle cells via targeting IGFBP-5 and modulating the mTOR/STAT3 signaling

. Data curation: Kai Li, Wei Huang. Formal analysis: Kai Li, Xiaoqing Zhang. Funding acquisition: Jin Pan. Investigation: Kai Li, Wei Huang. Methodology: Wei Huang. Project administration: Wei Huang ... . Supervision: Jin Pan. Validation: Wei Huang, Xiaoqing Zhang. Writing ± original draft: Jin Pan. 12 / 14 Writing ± review & editing: Jin Pan, Kai Li, Xiaoqing Zhang. 13 / 14 1. Gurha P. MicroRNAs in

A Novel Multiplex HRM Assay to Detect Clopidogrel Resistance

Zhang, Guoling You, Xiaoqing Zhang & Qihua FuDepartment of Laboratory Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, P.R. ChinaXiaowei Ma AuthorsSearch for ... • Google Scholar Search for Xiaoqing Zhang in:Nature Research journals • PubMed • Google Scholar Search for Qihua Fu in:Nature Research journals • PubMed • Google Scholar Contributions Q.H.F. and L.C.Z

Separation of Antioxidant Peptides from Pepsin Hydrolysate of Whey Protein Isolate by ATPS of EOPO Co-polymer (UCON)/Phosphate

An aqueous two-phase system (ATPS) consisting of poly(ethylene glycol-ran-propylene glycol) monobutyl ether (UCON)/phosphate was developed for the separation of the antioxidant peptides from pepsin hydrolysate of Whey Protein Isolate (WPI). The efficiency of the separation was evaluated based on the DPPH radical scavenging activity, ABTS radical scavenging activity and ferric...

The Government’s Environment Policy Index Impact on Recycler Behavior in Electronic Products Closed-Loop Supply Chain

We establish the model of multilevel closed-loop supply chain (CLSC) which included raw material supplier, manufacturer, distributor, retailer, and third-party recycler based on system dynamics (SD). Considering factors which influence recycler behavior-environmental policy index and recovery delay, we apply SD software—Vensim—to simulate CLSC model and study recycler behavior’s...

The Government’s Environment Policy Index Impact on Recycler Behavior in Electronic Products Closed-Loop Supply Chain

We establish the model of multilevel closed-loop supply chain (CLSC) which included raw material supplier, manufacturer, distributor, retailer, and third-party recycler based on system dynamics (SD). Considering factors which influence recycler behavior-environmental policy index and recovery delay, we apply SD software—Vensim—to simulate CLSC model and study recycler behavior’s...

Nucleosome eviction along with H3K9ac deposition enhances Sox2 binding during human neuroectodermal commitment

Neuroectoderm is an important neural precursor. However, chromatin remodeling and its epigenetic regulatory roles during the differentiation of human neuroectodermal cells (hNECs) from human embryonic stem cells (hESCs) remain largely unexplored. Here, we obtained hNECs through directed differentiation from hESCs, and determined chromatin states in the two cell types. Upon...

Three-dimensional printing as an aid to airway evaluation after tracheotomy in a patient with laryngeal carcinoma

have no competing interests. Authors’ contributions Bin Han: data collection and drafting the manuscript. Yajie Liu: data collection and drafting the manuscript. Xiaoqing Zhang: revising the manuscript

A Novel Missense Mutation of GATA4 in a Chinese Family with Congenital Heart Disease

Background Congenital heart disease (CHD) is the most prevalent type of birth defect in human, with high morbidity in infant. Several genes essential for heart development have been identified. GATA4 is a pivotal transcription factor that can regulate the cardiac development. Many GATA4 mutations have been identified in patients with different types of CHD. Aims In this study...

Efficient and Fast Differentiation of Human Neural Stem Cells from Human Embryonic Stem Cells for Cell Therapy

Yihong Chen,4 Li Chen,1 Ying Zhang,1 Yuehua Liu,1 Xiaoqing Zhang,5 Hua He,4 and Zhengliang Gao5 1Shanghai Stomatological Hospital, Fudan University, Shanghai 200001, China 2Shanghai Tenth People’s

Mathematical Modeling of Transient Responses in a Large Scale Multiconductor System

Copyright © 2014 Caiwang Sheng and Xiaoqing Zhang. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in

Mathematical Modeling of Transient Responses in a Large Scale Multiconductor System

Copyright © 2014 Caiwang Sheng and Xiaoqing Zhang. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in

Influence of IL-18 and IL-10 Polymorphisms on Tacrolimus Elimination in Chinese Lung Transplant Patients

November 2016; Published 26 January 2017 Academic Editor: Gad Rennert Copyright © 2017 Xiaoqing Zhang et al. This is an open access article distributed under the Creative Commons Attribution License ... have anything to disclose regarding funding or conflict of interests with respect to this manuscript. Authors’ Contributions Gening Jiang, Junwei Fan, and Xiaoqing Zhang conceived and designed the