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Improved phylogenetic resolution for Y-chromosome Haplogroup O2a1c-002611

Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grant agreement No. 646612) granted to Martine Robbeets. Author information Author notes Xiaotian Yao and ... WangDepartment of Genetics, Harvard Medical School, Boston, MA 02115, United StatesChuan-Chao Wang AuthorsSearch for Xiaotian Yao in:Nature Research journals • PubMed • Google Scholar Search for Senwei Tang

YHap: a population model for probabilistic assignment of Y haplogroups from re-sequencing data

Background Y haplogroup analyses are an important component of genealogical reconstruction, population genetic analyses, medical genetics and forensics. These fields are increasingly moving towards use of low-coverage, high throughput sequencing. While there have been methods recently proposed for assignment of Y haplogroups on the basis of high-coverage sequence data, assignment...

Haplotype-assisted accurate non-invasive fetal whole genome recovery through maternal plasma sequencing

Background The applications of massively parallel sequencing technology to fetal cell-free DNA (cff-DNA) have brought new insight to non-invasive prenatal diagnosis. However, most previous research based on maternal plasma sequencing has been restricted to fetal aneuploidies. To detect specific parentally inherited mutations, invasive approaches to obtain fetal DNA are the...