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Cost-effectiveness of option B+ in prevention of mother-to-child transmission of HIV in Yunnan Province, China

Although Option B+ may be more costly than Options B, it may provide additional health benefits that are currently unclear in Yunnan province. We created deterministic models to estimate the cost-effectiveness of Option B+. Data were used in two deterministic models simulating a cohort of 2000 HIV+ pregnant women. A decision tree model simulated the number of averted infants...

Effects of a Portable Peritoneal Lavage Device on Dogs with Seawater-Immersed Open Abdominal Injury

, and Xiaowen Wang Department of General Surgery, The Affiliated Southeast Hospital of Xiamen University (the 175th Hospital of PLA), Zhangzhou, China Correspondence should be addressed to Song Zhou

Effects of a Portable Peritoneal Lavage Device on Dogs with Seawater-Immersed Open Abdominal Injury

, and Xiaowen Wang Department of General Surgery, The Affiliated Southeast Hospital of Xiamen University (the 175th Hospital of PLA), Zhangzhou, China Correspondence should be addressed to Song Zhou

Carrier re-sequencing reveals rare but benign variants in recessive deafness genes

For recessive Mendelian disorders, determining the pathogenicity of rare, non-synonymous variants in known causative genes can be challenging without expanded pedigrees and/or functional analysis. In this study, we proposed to establish a database of rare but benign variants in recessive deafness genes by systematic carrier re-sequencing. As a pilot study, 30 heterozygous...

Epigenetic profiling for the molecular classification of metastatic brain tumors

. Jalas 3 4 James S. Wilmott 5 Parvinder Hothi 6 Xiaowen Wang 1 Yuki Takasumi 4 Michael E. Buckland 7 John F. Thompson 5 8 Georgina V. Long Charles S. Cobbs 5 6 9 Ilya Shmulevich 2 Daniel F. Kelly 3 Richard

When the Fight against Fungi Goes Wrong

. - OPEN ACCESS Funding: This work was funded by the ERA-Net for Research Programmes on Rare Diseases "EUROCMC," and Xiaowen Wang was supported by National Natural Science Foundation of China (81501727

Technology roadmap for smart electric vehicle-to-grid (V2G) of residential chargers

Smart grid is defined as the overlaying of a unified communications and control system onto the existing power delivery infrastructure to provide the right information and the right entity at the right time. It helps even out demand spikes and uses resource mix more efficiently. It is a better integration, or “system balancing,” of variable resources, like wind power. Many of the...

Health-related quality of life in pregnant women living with HIV: a comparison of EQ-5D and SF-12

This paper investigates the properties and performance of the two generic measures, EQ-5D and SF-12, for Health-Related Quality of Life (HRQoL) assessments of pregnant women living with HIV in Kunming City, Yiliang County, Daguan County, Longchuan County, Tengchong County, Longling County and Fengqing County in Yunnan Province, China. As part of a screening programme for the...

Graphene oxide-enhanced sol-gel transition sensitivity and drug release performance of an amphiphilic copolymer-based nanocomposite

We report the fabrication of a highly sensitive amphiphilic copolymer-based nanocomposite incorporating with graphene oxide (GO), which exhibited a low-intensity UV light-triggered sol-gel transition. Non-cytotoxicity was observed for the composite gels after the GO incorporation. Of particular interest were the microchannels that were formed spontaneously within the GO...

Molecular etiology and genotype-phenotype correlation of Chinese Han deaf patients with type I and type II Waardenburg Syndrome

Waardenburg syndrome (WS) characterized by sensorineural hearing loss and pigmentary abnormalities is genetically heterogeneous and phenotypically variable. This study investigated the molecular etiology and genotype-phenotype correlation of WS in 36 Chinese Han deaf probands and 16 additional family members that were clinically diagnosed with WS type I (WS1, n = 8) and type II...

Cripto-1 Promotes the Epithelial-Mesenchymal Transition in Esophageal Squamous Cell Carcinoma Cells

experiments. Chun Huang and Xiaowen Wang performed the experiments. Chun Huang and Jinqiu Zhao conducted the statistical analysis. Chun Huang drafted the paper. Acknowledgments The authors thank Dr. Frank for

Selenium Augments microRNA Directed Reprogramming of Fibroblasts to Cardiomyocytes via Nanog

Cardiology, Shandong Provincial Hospital, Jinan, Shandong 250001, ChinaKefeng Lu AuthorsSearch for Xiaowen Wang in:Nature Research journals • PubMed • Google ScholarSearch for Conrad P Hodgkinson in:Nature

EV71 virus-like particles produced by co-expression of capsid proteins in yeast cells elicit humoral protective response against EV71 lethal challenge

Background Enterovirus 71 (EV71) is the most common causative pathogens of hand, foot and mouth disease (HFMD) associated with severe neurological complications. There is a great need to develop prophylactic vaccine against EV71 infection. Results EV71 virus-like particle (VLP) was produced in yeast expression system by the co-expression of four EV71 structural proteins VP1–VP4...

Overexpression of Poplar Xylem Sucrose Synthase in Tobacco Leads to a Thickened Cell Wall and Increased Height

Sucrose synthase (SuSy) is considered the first key enzyme for secondary growth because it is a highly regulated cytosolic enzyme that catalyzes the reversible conversion of sucrose and UDP into UDP-glucose and fructose. Although SuSy enzymes preferentially functions in the direction of sucrose cleavage at most cellular condition, they also catalyze the synthetic reaction. We...

EV71 virus-like particles produced by co-expression of capsid proteins in yeast cells elicit humoral protective response against EV71 lethal challenge

Enterovirus 71 (EV71) is the most common causative pathogens of hand, foot and mouth disease (HFMD) associated with severe neurological complications. There is a great need to develop prophylactic vaccine against EV71 infection. EV71 virus-like particle (VLP) was produced in yeast expression system by the co-expression of four EV71 structural proteins VP1–VP4. Immunization with...

A 1.6-Mb Microdeletion in Chromosome 17q22 Leads to NOG-Related Symphalangism Spectrum Disorder without Intellectual Disability

Microdeletions in chromosome 17q22, where the NOG gene resides, have been reported leading to the NOG-related symphalangism spectrum disorder (NOG-SSD), intellectual disability and other developmental abnormalities. In this study we reported a dominant Chinese Han family segregating with typical NOG-SSD symptoms including proximal symphalangism, conductive hearing loss, amblyopia...

Targeted Next-Generation Sequencing in Uyghur Families with Non-Syndromic Sensorineural Hearing Loss

The mutation spectrum of deafness genes may vary in different ethnical groups. In this study, we investigated the genetic etiology of nonsyndromic deafness in four consanguineous and two multiplex Uyghur families in which mutations in common deafness genes GJB2, SLC26A4 and MT-RNR1 were excluded. Targeted next-generation sequencing of 97 deafness genes was performed in the...

The Myeloid LSECtin Is a DAP12-Coupled Receptor That Is Crucial for Inflammatory Response Induced by Ebola Virus Glycoprotein

Fatal Ebola virus infection is characterized by a systemic inflammatory response similar to septic shock. Ebola glycoprotein (GP) is involved in this process through activating dendritic cells (DCs) and macrophages. However, the mechanism is unclear. Here, we showed that LSECtin (also known as CLEC4G) plays an important role in GP-mediated inflammatory responses in human DCs...

Dual-functional transdermal drug delivery system with controllable drug loading based on thermosensitive poloxamer hydrogel for atopic dermatitis treatment

, Kowloon, Hong Kong, ChinaWenyi Wang, Patrick C. L. Hui, Frency S. F. Ng, Chi-Wai Kan, Xiaowen Wang & Huawen HuInstitute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, New Territories ... • PubMed • Google ScholarSearch for Frency S. F. Ng in:Nature Research journals • PubMed • Google ScholarSearch for Chi-Wai Kan in:Nature Research journals • PubMed • Google ScholarSearch for Xiaowen Wang

Efficacy of Modafinil on Fatigue and Excessive Daytime Sleepiness Associated with Neurological Disorders: A Systematic Review and Meta-Analysis

BackgroundModafinil is a novel wake-promoting agent approved by the FDA ameliorating excessive daytime sleepiness (EDS) in three disorders: narcolepsy, shift work sleep disorder and obstructive sleep apnea. Existing trials of modafinil for fatigue and EDS associated with neurological disorders provided inconsistent results. This meta-analysis was aimed to assess drug safety and...