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The radiosensitizing effect of doranidazole on human colorectal cancer cells exposed to high doses of irradiation

Background This paper investigates the effects of a new radiosensitizer, doranidazole, and enhancing irradiation on colorectal cancer cells. Methods The radiosensitizing effect of doranidazole was determined using colony formation and propidium iodide (PI) assays to measure cell growth inhibition and the cell killing effect of human colorectal cancer cell lines exposed to high...

Mechanistic Study on the Nuclear Modifier Gene MSS1 Mutation Suppressing Neomycin Sensitivity of the Mitochondrial 15S rRNA C1477G Mutation in Saccharomyces cerevisiae

The phenotypic manifestation of mitochondrial DNA (mtDNA) mutations can be modulated by nuclear genes and environmental factors. However, neither the interaction among these factors nor their underlying mechanisms are well understood. The yeast Saccharomyces cerevisiae mtDNA 15S rRNA C1477G mutation (PR) corresponds to the human 12S rRNA A1555G mutation. Here we report that a...

Quantitative Analysis of Global Proteome and Lysine Acetylome Reveal the Differential Impacts of VPA and SAHA on HL60 Cells

 & Quan Wu AuthorsSearch for Xiaoyu Zhu in:Nature Research journals • PubMed • Google ScholarSearch for Xin Liu in:Nature Research journals • PubMed • Google ScholarSearch for Zhongyi Cheng in:Nature

EIN3 and ORE1 Accelerate Degreening during Ethylene-Mediated Leaf Senescence by Directly Activating Chlorophyll Catabolic Genes in Arabidopsis

Degreening, caused by chlorophyll degradation, is the most obvious symptom of senescing leaves. Chlorophyll degradation can be triggered by endogenous and environmental cues, and ethylene is one of the major inducers. ETHYLENE INSENSITIVE3 (EIN3) is a key transcription factor in the ethylene signaling pathway. It was previously reported that EIN3, miR164, and a NAC (NAM, ATAF...

Nuclear Modifier MTO2 Modulates the Aminoglycoside-Sensitivity of Mitochondrial 15S rRNA C1477G Mutation in Saccharomyces cerevisiae

The phenotypic manifestations of mitochondrial DNA (mtDNA) mutations are modulated by mitochondrial DNA haplotypes, nuclear modifier genes and environmental factors. The yeast mitochondrial 15S rRNA C1477G (PR or PR454) mutation corresponds to the human 12S rRNA C1494T and A1555G mutations, which are well known as primary factors for aminoglycoside-induced nonsyndromic deafness...

A novel early SKIP mode detection method for coarse grain quality in H.264/SVC

Hao Zhang 0 Xiaoyu Zhu 0 Xuan He 0 0 School of Information Science and Engineering, Central South University , Changsha, Hunan, China Various fast mode decision algorithms are proposed to reduce

MTO1 Worked as a Modifier in the Aminoglycosides Sensitivity of Yeast Carrying a Mitochondrial 15S rRNA C1477G Mutation

Sciences, Zhejiang University for the checking of the English of this manuscript. Conceived and designed the experiments: Xiaoyu Zhu Xufen Zhu QY. Performed the experiments: Xiaoyu Zhu XH WW QZ ZY YD Xufen ... Zhu. Analyzed the data: Xiaoyu Zhu Xufen Zhu QY. Wrote the paper: Xiaoyu Zhu Xufen Zhu QY. 1. Wang X , Yan Q , Guan MX . Combination of the loss of cmnm5U34 with the lack of s2U34 modifications of

Randomized, controlled trial comparing laryngeal mask versus endotracheal intubation during neonatal resuscitation---a secondary publication

Background This study aimed to study the feasibility, efficacy and safety of using laryngeal mask (LM) ventilation compared with endotracheal intubation (ETI) during neonatal resuscitation. Methods Neonates with a heart rate below 60 beats per minute despite 30 s of face mask ventilation were assigned quasi-randomly (odd/even birth date) to LM (n = 36) or ETI (n = 32) ventilation...

Randomized, controlled trial comparing laryngeal mask versus endotracheal intubation during neonatal resuscitation---a secondary publication

This study aimed to study the feasibility, efficacy and safety of using laryngeal mask (LM) ventilation compared with endotracheal intubation (ETI) during neonatal resuscitation. Neonates with a heart rate below 60 beats per minute despite 30 s of face mask ventilation were assigned quasi-randomly (odd/even birth date) to LM (n = 36) or ETI (n = 32) ventilation. Differences in...

Comparison of postoperative visual quality after SMILE and LASEK for high myopia: A 1-year outcome

Contributions Conceptualization: Xiaoyu Zhu, Leilei Zou, Jinhui Dai. Data curation: Xiaoyu Zhu, Leilei Zou, Manrong Yu, Jinhui Dai. Formal analysis: Xiaoyu Zhu, Leilei Zou, Manrong Yu, Jinhui Dai. Funding ... acquisition: Jinhui Dai. Investigation: Xiaoyu Zhu, Leilei Zou, Manrong Yu, Chen Qiu, Minjie Chen, Jinhui Dai. Methodology: Xiaoyu Zhu, Leilei Zou, Jinhui Dai. Project administration: Jinhui Dai. Resources

Effect of Altered Retinal Cones/Opsins on Refractive Development under Monochromatic Lights in Guinea Pigs

eye growth. Conflicts of Interest The authors declare that there is no conflicts of interest regarding the publication of this paper. Authors’ Contributions Leilei Zou and Xiaoyu Zhu contributed

Effect of Altered Retinal Cones/Opsins on Refractive Development under Monochromatic Lights in Guinea Pigs

cones and opsins in eye growth. Conflicts of Interest The authors declare that there is no conflicts of interest regarding the publication of this paper. Authors’ Contributions Leilei Zou and Xiaoyu Zhu

Effect of Altered Retinal Cones/Opsins on Refractive Development under Monochromatic Lights in Guinea Pigs

declare that there is no conflicts of interest regarding the publication of this paper. Authors? Contributions Leilei Zou and Xiaoyu Zhu contributed equally to the work presented here and should therefore

Astaxanthin Promotes Nrf2/ARE Signaling to Alleviate Renal Fibronectin and Collagen IV Accumulation in Diabetic Rats

November 2017; Accepted 19 February 2018; Published 21 March 2018 Academic Editor: Laurent Crenier Copyright © 2018 Xiaoyu Zhu et al. This is an open access article distributed under the Creative Commons ... conflicts of interest with respect to the research, authorship, and/or publication of this article. Authors’ Contributions Xiaoyu Zhu and Yongjun Chen contributed equally to this study. Acknowledgments This

Astaxanthin Promotes Nrf2/ARE Signaling to Alleviate Renal Fibronectin and Collagen IV Accumulation in Diabetic Rats

November 2017; Accepted 19 February 2018; Published 21 March 2018 Academic Editor: Laurent Crenier Copyright © 2018 Xiaoyu Zhu et al. This is an open access article distributed under the Creative Commons ... conflicts of interest with respect to the research, authorship, and/or publication of this article. Authors’ Contributions Xiaoyu Zhu and Yongjun Chen contributed equally to this study. Acknowledgments This

The incidence, risk factors and outcomes of early bloodstream infection in patients with malignant hematologic disease after unrelated cord blood transplantation: a retrospective study

Bloodstream infection (BSI) is one of the major causes of morbidity and mortality for patients undergoing hematopoietic stem cell transplantation (HSCT). The unrelated cord blood transplantation (UCBT) can provided opportunities for patients without suitable donors for bone marrow transplantation (BMT) and peripheral blood stem cell transplantation (PBSCT), while few studies have...

Association between total water intake and dietary intake of pregnant and breastfeeding women in China: a cross-sectional survey

Pregnant and lactating women are at high risk of insufficient water intake. The cross-sectional study was mainly designed to evaluate the water intake, including total water intake (TWI), plain water intake, and water intake from beverages and foods of 200 pregnant women and 150 breastfeeding women in Beijing. A semi-quantitative Food Frequency Questionnaire (FFQ) was employed to...