Advanced search    

Search: authors:"Xin Guan"

61 papers found.
Use AND, OR, NOT, +word, -word, "long phrase", (parentheses) to fine-tune your search.

In vitro culture of mammalian inner ear hair cells

 ZhangXiao-hui CangYe ChenMin-xin Guan Report First Online: 06 September 2018 25 Downloads Abstract Auditory function in vertebrates depends on the transduction of sound vibrations into electrical

Grey Relational Analysis for Hesitant Fuzzy Sets and Its Applications to Multiattribute Decision-Making

Correspondence should be addressed to Guidong Sun; moc.361@dgshwds Received 16 October 2017; Revised 11 March 2018; Accepted 25 March 2018; Published 6 May 2018 Academic Editor: Peide Liu Copyright © 2018 Xin ... Guan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original

Acupuncture in migraine prophylaxis in Czech patients: an open-label randomized controlled trial

Acupuncture in migraine prophylaxis in Czech patients: an open-label randomized controlled trial Frantisek Musil,1 Jitka Pokladnikova,1,2 Zbysek Pavelek,3 Bo Wang,4 Xin Guan,4 Martin Valis3 1Czech ... ) Xin guan 4 Background: Adjuvant acupuncture for the symptomatic treatment of migraine reduces the frequency of headaches and may be at least similarly effective to treatment with prophylactic drugs

Evaluation of ex vivo produced endothelial progenitor cells for autologous transplantation in primates

BackgroundAutologous transplantation of endothelial progenitor cells (EPCs) is a promising therapeutic approach in the treatment of various vascular diseases. We previously reported a two-step culture system for scalable generation of human EPCs derived from cord blood CD34+ cells ex vivo. Here, we now apply this culture system to expand and differentiate human and nonhuman...

Relationship between auxiliary gamma subunits and mallotoxin on BK channel modulation

The large-conductance, calcium- and voltage-activated K+(BK) channel consists of the pore-forming α subunits (BKα) and auxiliary subunits. The auxiliary γ1-3 subunits potently modulate the BK channel by shifting its voltage-dependence of channel activation toward the hyperpolarizing direction by approximately 145 mV (γ1), 100 mV (γ2), and 50 mV (γ3). Mallotoxin is a potent small...

The role of mitochondria in osteogenic, adipogenic and chondrogenic differentiation of mesenchymal stem cells

, reactive oxygen species. COMPLIANCE WITH ETHICS GUIDELINES Qianqian Li, Zewen Gao, Ye Chen, and Min-Xin Guan declare that they have no conflict of interest with respect to research, authorship, and/or

Neuroprotective Effect of the Ginsenoside Rg1 on Cerebral Ischemic Injury In Vivo and In Vitro Is Mediated by PPARγ-Regulated Antioxidative and Anti-Inflammatory Pathways

@4791ouggnefiahz and Li-Xin Guan; moc.361@777nixilnaug Received 19 February 2017; Revised 29 April 2017; Accepted 9 May 2017; Published 1 June 2017 Academic Editor: Junqing Yang Copyright © 2017 Yang Li et al ... ’ Contributions Yang Li, Feng-Guo Zhai, and Li-Xin Guan designed the experiments and wrote the manuscript. Yang Li, Yue Guan, Ying Wang, and Chun-Lei Yu performed the experiments and analyzed the data. All authors

A small-molecule/cytokine combination enhances hematopoietic stem cell proliferation via inhibition of cell differentiation

Background Accumulated evidence supports the potent stimulating effects of multiple small molecules on the expansion of hematopoietic stem cells (HSCs) which are important for the therapy of various hematological disorders. Here, we report a novel, optimized formula, named the SC cocktail, which contains a combination of three such small molecules and four cytokines. Methods...

Large-scale ex vivo generation of human neutrophils from cord blood CD34+ cells

Conventional high-dose chemotherapy frequently leads to severe neutropenia, during which patients experience a high risk of infection. Although support care with donor’s neutrophils is possible this choice is largely hampered by the limited availability of matched donors. To overcome this problem, we explored a large-scale ex vivo production of neutrophils from hematopoietic stem...

Neuroprotective Effect and Mechanism of Thiazolidinedione on Dopaminergic Neurons In Vivo and In Vitro in Parkinson’s Disease

The aim of the present study was to gain insight into the neuroprotection effects and mechanism of thiazolidinedione pioglitazone in both in vitro and in vivo MPP

An effective ex-vivo approach for inducing endothelial progenitor cells from umbilical cord blood CD34+ cells

Background Transplantation of endothelial progenitor cells (EPCs)/endothelial cells (ECs) has been used for the treatment of ischemic diseases and hemophilia A, due to their great capacity for producing factor VIII and for repairing vascular damage. We established an effective approach to stimulate the expansion and differentiation of EPCs for potential therapeutic applications...

Modeling autosomal dominant optic atrophy using induced pluripotent stem cells and identifying potential therapeutic targets

BackgroundMany retinal degenerative diseases are caused by the loss of retinal ganglion cells (RGCs). Autosomal dominant optic atrophy is the most common hereditary optic atrophy disease and is characterized by central vision loss and degeneration of RGCs. Currently, there is no effective treatment for this group of diseases. However, stem cell therapy holds great potential for...

Unexplained persistent postpartum palpitations and tachycardia due to Group A Streptococcus

Background Group A Streptococcus is one of the most morbid infections in modern obstetric practice. Pregnant women are known to have a 20-fold increased risk of invasive Group A Streptococcus with greatest risk in the first 4 days postpartum. The overwhelming majority of these infections will present with fever, uterine tenderness, or vaginal discharge. A much smaller subset may...

A peep into mitochondrial disorder: multifaceted from mitochondrial DNA mutations to nuclear gene modulation

hearing loss; rRNA, ribosomal RNA; SSU, small subunit. COMPLIANCE WITH ETHICS GUIDELINES Chao Chen, Ye Chen, and Min-Xin Guan declare that they have no conflict of interest. This article does not contain

Research Advance in Intestinal Mucosal Barrier and Pathogenesis of Crohn’s Disease

approach in the prevention of CD in the future. Competing Interests There is no potential conflict of interests. Authors’ Contributions Kuan Wang, Lu-yi Wu, Chuan-zi Dou, and Xin Guan contributed equally to

Research Advance in Intestinal Mucosal Barrier and Pathogenesis of Crohn’s Disease

approach in the prevention of CD in the future. Competing Interests There is no potential conflict of interests. Authors’ Contributions Kuan Wang, Lu-yi Wu, Chuan-zi Dou, and Xin Guan contributed equally to

A deafness-associated tRNAAsp mutation alters the m1G37 modification, aminoacylation and stability of tRNAAsp and mitochondrial function

In this report, we investigated the pathogenic mechanism underlying the deafness-associated mitochondrial(mt) tRNAAsp 7551A > G mutation. The m.7551A > G mutation is localized at a highly conserved nucleotide(A37), adjacent (3′) to the anticodon, which is important for the fidelity of codon recognition and stabilization in functional tRNAs. It was anticipated that the m.7551A > G...

Liver-targeting Resibufogenin-loaded poly(lactic-co-glycolic acid)-D-α-tocopheryl polyethylene glycol 1000 succinate nanoparticles for liver cancer therapy

Liver-targeting Resibufogenin-loaded poly(lactic-co-glycolic acid)-D-α-tocopheryl polyethylene glycol 1000 succinate nanoparticles for liver cancer therapy Qiuchen Chu,1,* Hong Xu,2,* Meng Gao,1 Xin

The cytoskeleton is disrupted by the bacterial effector HrpZ, but not by the bacterial PAMP flg22, in tobacco BY-2 cells

. Acknowledgements This work was supported by the BACCHUS Interreg project and a fellowship of the Chinese Scholarship Council to Xin Guan. We would like to thank Dr Yubin Kashef (Zoology Institute Cell and

Mitochondrial Genome Sequencing and Development of Genetic Markers for the Detection of DNA of Invasive Bighead and Silver Carp (Hypophthalmichthys nobilis and H. molitrix) in Environmental Water Samples from the United States

Invasive Asian bighead and silver carp (Hypophthalmichthys nobilis and H. molitrix) pose a substantial threat to North American aquatic ecosystems. Recently, environmental DNA (eDNA), genetic material shed by organisms into their environment that can be detected by non-invasive sampling strategies and genetic assays, has gained recognition as a tool for tracking the invasion...