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11 papers found.
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Identification of transthyretin as a novel interacting partner for the δ subunit of GABAA receptors

Contributions Conceptualization: Li Zhou, Gong Chen. Data curation: Li Zhou, Xin Tang, Xinyi Li, Yuting Bai. Formal analysis: Li Zhou, Xin Tang, Xinyi Li. Funding acquisition: Gong Chen. Investigation: Li ... Zhou, Xinyi Li, Yuting Bai, Gong Chen. Methodology: Li Zhou, Xin Tang, Yuting Bai. Project administration: Li Zhou, Gong Chen. Resources: Li Zhou, Xinyi Li, Joel N. Buxbaum, Gong Chen. Software: Li

Prevalence of visual impairment and outcomes of cataract surgery in Chaonan, South China

, Chongren Zheng. Formal analysis: Xiujuan Zhang. Funding acquisition: Dennis Shun-Chiu Lam. Investigation: Xiujuan Zhang. Methodology: Emmy Y. Li, Christopher Kai-Shun Leung, David C. Musch, Xin Tang ... Shun-Chiu Lam. Validation: Emmy Y. Li, Christopher Kai-Shun Leung, David C. Musch, Xin Tang, Mingguang He, David F. Chang, Dennis Shun-Chiu Lam. Writing ± original draft: Xiujuan Zhang. Writing

Aphid performance changes with plant defense mediated by Cucumber mosaic virus titer

Background Cucumber mosaic virus (CMV) causes appreciable losses in vegetables, ornamentals and agricultural crops. The green peach aphid, Myzus persicae Sulzer (Aphididae) is one of the most efficient vectors for CMV. The transmission ecology of aphid-vectored CMV has been well investigated. However, the detailed description of the dynamic change in the plant-CMV-aphid...

Proteomics analysis of high lipid-producing strain Mucor circinelloides WJ11: an explanation for the mechanism of lipid accumulation at the proteomic level

Background The oleaginous fungus, Mucor circinelloides, is attracting considerable interest as it produces oil rich in γ-linolenic acid. Nitrogen (N) deficiency is a common strategy to trigger the lipid accumulation in oleaginous microorganisms. Although a simple pathway from N depletion in the medium to lipid accumulation has been elucidated at the enzymatic level, global...

Complete Genome Sequence of a High Lipid-Producing Strain of Mucor circinelloides WJ11 and Comparative Genome Analysis with a Low Lipid-Producing Strain CBS 277.49

The genome of a high lipid-producing fungus Mucor circinelloides WJ11 (36% w/w lipid, cell dry weight, CDW) was sequenced and compared with that of the low lipid-producing strain, CBS 277.49 (15% w/w lipid, CDW), which had been sequenced by Joint Genome Institute. The WJ11 genome assembly size was 35.4 Mb with a G+C content of 39.7%. The general features of WJ11 and CBS 277.49...

Comparison of Biochemical Activities between High and Low Lipid-Producing Strains of Mucor circinelloides: An Explanation for the High Oleaginicity of Strain WJ11

The oleaginous fungus, Mucor circinelloides, is one of few fungi that produce high amounts of γ-linolenic acid (GLA); however, it usually only produces <25% lipid. Nevertheless, a new strain (WJ11) isolated in this laboratory can produce lipid up to 36% (w/w) cell dry weight (CDW). We have investigated the potential mechanism of high lipid accumulation in M. circinelloides WJ11...

A Novel Cell Traction Force Microscopy to Study Multi-Cellular System

Traction forces exerted by adherent cells on their microenvironment can mediate many critical cellular functions. Accurate quantification of these forces is essential for mechanistic understanding of mechanotransduction. However, most existing methods of quantifying cellular forces are limited to single cells in isolation, whereas most physiological processes are inherently multi...

Long-term consumption of caffeine-free high sucrose cola beverages aggravates the pathogenesis of EAE in mice

Epidemiological data provide strong evidence of dramatically increasing incidences of many autoimmune diseases in the past few decades, mainly in western and westernized countries. Recent studies clearly revealed that ‘Western diet’ increases the risk of autoimmune diseases at least partially via disrupting intestinal tight junctions and altering the construction and metabolites...

Attenuation of Cell Mechanosensitivity in Colon Cancer Cells during In Vitro Metastasis

Human colon carcinoma (HCT-8) cells show a stable transition from low to high metastatic state when cultured on appropriately soft substrates (21 kPa). Initially epithelial (E) in nature, the HCT-8 cells become rounded (R) after seven days of culture on soft substrate. R cells show a number of metastatic hallmarks [1]. Here, we use gradient stiffness substrates, a bio-MEMS force...

A mechanically-induced colon cancer cell population shows increased metastatic potential

Background Metastasis accounts for the majority of deaths from cancer. Although tumor microenvironment has been shown to have a significant impact on the initiation and/or promotion of metastasis, the mechanism remains elusive. We previously reported that HCT-8 colon cancer cells underwent a phenotypic transition from an adhesive epithelial type (E-cell) to a rounded dissociated...

Diabetes Mellitus and Risk of Alzheimer's Disease and Dementia with Stroke in a Multiethnic Cohort

Jose A. Luchsinger Ming-Xin Tang Yaakov Stern Steven Shea Richard Mayeux Research on the relation between diabetes mellitus and dementia has produced conflicting results, and the relation has not