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Regulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitination

TIR domain-containing adaptor inducing interferon-β (TRIF) is an essential adaptor protein required for innate immune responses mediated by Toll-like receptor (TLR) 3- and TLR4. Here we identify USP19 as a negative regulator of TLR3/4-mediated signaling. USP19 deficiency increases the production of type I interferons (IFN) and proinflammatory cytokines induced by poly(I:C) or LPS...

Clinical characteristics of epithelioid hemangioendothelioma: a single-center retrospective study

Epithelioid hemangioendothelioma (EHE) is a rare malignant vascular neoplasm with increasing incidence. However, its clinical characteristics remain unclear due to its low incidence. This study aimed to investigate the features of EHE. Patients with EHE treated at our institution between January 2000 and June 2018 were enrolled. Data including demographic characteristics...

Advantages of using reduced-volume intensity modulated radiation therapy for the treatment of nasopharyngeal carcinoma: a retrospective paired study

The definition of clinical target volume (CTV) in intensity modulated radiation therapy (IMRT) for nasopharyngeal carcinoma (NPC) has not been addressed. We performed this study to assess the feasibility and efficacy of using IMRT with reduced-volume CTV for the treatment of nasopharyngeal carcinoma. We retrospectively reviewed 293 non-metastatic NPC patients treated with IMRT...

Suppression of grazing-induced instability in single degree-of-freedom impact oscillators

As a typical non-smooth bifurcation, grazing bifurcation can induce instability of elementary near-grazing impact periodic motion in impact oscillators. In this paper, the stability for near-grazing period-one impact motion to suppress grazing-induced instabilities is analyzed, based on which, a control strategy is proposed. The commonly-used leading order zero time discontinuity...

L-fuzzifying topological vector spaces

Hindawi Publishing Corporation International Journal of Mathematics and Mathematical Sciences C.-H. Yan 0 C.-X. Wu 0 0 Cong-xin Wu: Department of Mathematics, Harbin Institute of Technology , Harbin

L-fuzzifying topological vector spaces

Hindawi Publishing Corporation International Journal of Mathematics and Mathematical Sciences C.-H. Yan 0 C.-X. Wu 0 0 Cong-xin Wu: Department of Mathematics, Harbin Institute of Technology , Harbin

A dynamic bid price approach for the seat inventory control problem in railway networks with consideration of passenger transfer

: Wuyang Yuan. Writing ± review & editing: Xin Wu. 21 / 23 22 / 23 1. Sibdari S , Lin KY , Chellappan S. Multiproduct revenue management: An empirical study of Auto Train at Amtrak . 2008 ; 7 ( 2 ): 172

Sialyltransferase ST3GAL1 promotes cell migration, invasion, and TGF-β1-induced EMT and confers paclitaxel resistance in ovarian cancer

China(81302259). Author information Author notes These authors contributed equally: Xin Wu, Junda Zhao AffiliationsKey Laboratory of Female Reproductive Endocrine Related Diseases; The Obstetrics and ... , ChinaYuanyuan RuanThe Obstetrics and Gynecology Hospital, Fudan University, Shanghai, 200011, ChinaLi Sun AuthorsSearch for Xin Wu in:Nature Research journals • PubMed • Google Scholar Search for Junda Zhao

Bevacizumab combined with chemotherapy vs single-agent therapy in recurrent glioblastoma: evidence from randomized controlled trials

Bevacizumab combined with chemotherapy vs single-agent therapy in recurrent glioblastoma: evidence from randomized controlled trials Zhouqing Chen,1,* Na Xu,2,* Chongshun Zhao,1 Tao Xue,1 Xin Wu,1

Abnormal resting state activity of left middle occipital gyrus and its functional connectivity in female patients with major depressive disorder

Women are more susceptible to major depressive disorder (MDD). A possible explanation is that women have a trait tendency to engage in a ruminative response style. Depending on cognitive model of depression, attention bias, memory bias and self-referential bias were closely related among depressed patients. Previous studies have explored the neural mechanism of the cognitive...

Different doses of tenecteplase vs alteplase in thrombolysis therapy of acute ischemic stroke: evidence from randomized controlled trials

Different doses of tenecteplase vs alteplase in thrombolysis therapy of acute ischemic stroke: evidence from randomized controlled trials Na Xu,1,2,* Zhouqing Chen,1,* Chongshun Zhao,1 Tao Xue,1 Xin

Prolyl hydroxylase domain 3 influences the radiotherapy efficacy of pancreatic cancer cells by targeting hypoxia-inducible factor-1α

Prolyl hydroxylase domain 3 influences the radiotherapy efficacy of pancreatic cancer cells by targeting hypoxia-inducible factor-1alpha Li-rui Tang,1,* Jun-xin Wu,1,* Shao-li Cai,2 Yun-xia Huang,1

Comparative analysis on microsurgical removal of craniopharyngioma via lateral supraorbital approach and standard pterional approach

Craniopharyngioma is a kind of intracranial benign tumor that is primarily treated with surgery. At present, a variety of surgical approaches are used for tumor resection. We have conducted a comparative analysis of the two approaches most used in our department. The study retrospectively analyzed the clinical data from 65 patients with craniopharyngioma surgically treated by the...

Ultra-wideband and Polarization-Insensitive Perfect Absorber Using Multilayer Metamaterials, Lumped Resistors, and Strong Coupling Effects

We theoretically and experimentally proposed a new structure of ultra-wideband and thin perfect metamaterial absorber loaded with lumped resistances. The thin absorber was composed of four dielectric layers, the metallic double split ring resonators (MDSRR) microstructures and a set of lumped resistors. The mechanism of the ultra-wideband absorption was analyzed and parametric...

Intestinal metastasis from primary ROS1-positive lung adenocarcinoma cancer patients responding to crizotinib

Intestinal metastasis from primary ROS1-positive lung adenocarcinoma cancer patients responding to crizotinib Hua-fei Chen,1,* Qu-xia Zhang,2,* You-cai Zhu,1 Kai-qi Du,1 Xiao-feng Li,1 Li-xin Wu,1

A comprehensive comparison of four species of Onchidiidae provides insights on the morphological and molecular adaptations of invertebrates from shallow seas to wetlands

Wang. Investigation: Guolv Xu, Tiezhu Yang, Jie Li, Xin Liu. Methodology: Tiezhu Yang, Dongfeng Wang, Xin Wu. Resources: Heding Shen. Software: Jie Li, Xin Wu. Writing ± original draft: Guolv Xu

Carbon black suppresses the osteogenesis of mesenchymal stem cells: the role of mitochondria

The rapid increase in carbon black poses threats to human health. We evaluated the effect of CB (Printex 90) on the osteogenesis of bone-marrow-derived mesenchymal stem cells (MSCs). Mitochondria play an important role in the osteogenesis of MSCs and are potential targets of nanomaterials, so we studied the role of mitochondria in the CB Printex 90-induced effects on osteogenesis...

The Combined Effect of Nonalcoholic Fatty Liver Disease and Metabolic Syndrome on Osteoporosis in Postmenopausal Females in Eastern China

’ Contributions Da-Zhi Chen, Qiao-Mai Xu, and Xiao-Xin Wu contributed equally to this work. Acknowledgments This study was financed by research grants from the Chinese High Tech Research and Development (863

The Combined Effect of Nonalcoholic Fatty Liver Disease and Metabolic Syndrome on Osteoporosis in Postmenopausal Females in Eastern China

’ Contributions Da-Zhi Chen, Qiao-Mai Xu, and Xiao-Xin Wu contributed equally to this work. Acknowledgments This study was financed by research grants from the Chinese High Tech Research and Development (863

In vitro and in vivo antioxidant activities of inulin

, Hong-Xin Wu. Data curation: Jun-Yan Yang. Investigation: Hong-Mei Shang, Jun-Yan Yang. Methodology: Hui Song. Project administration: Hui Song. Resources: Hai-Zhu Zhou, Ran Li. Software: Hai-Zhu ... Zhou. Supervision: Ran Li. Writing ± original draft: Hong-Mei Shang. Writing ± review & editing: Hong-Mei Shang, Hong-Xin Wu. 10 / 12 11 / 12 1. Liu W , Wang JJ , Zhang ZZ , Xu JN , Xie ZH , Slavin M