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A successful pregnancy in a patient with secondary hypertension caused by adrenal adenoma: a case report

Secondary hypertension is a rare complication in pregnancy that causes poor outcomes, such as preeclampsia, premature delivery, intrauterine growth retardation, stillbirths, spontaneous abortion or intrauterine death. Cushing’s disease caused by an adrenal adenoma is rare during pregnancy and may be overlooked by obstetricians and physicians, but can lead to hypertension...

GPAA1 promotes gastric cancer progression via upregulation of GPI-anchored protein and enhancement of ERBB signalling pathway

activates ERBB signalling to promote proliferation of gastric cancer Notes Xiao-Xin Zhang, Bo Ni, Qing Li and Li-Peng Hu contributed equally to this work. Abbreviations ALP:  Alkaline phosphatase

Efficacy of acupuncture versus sham acupuncture for postprandial distress syndrome: study protocol for a randomized controlled trial

Postprandial distress syndrome (PDS) has a considerable impact on quality of life. Our previous pilot trial suggested that acupuncture might be a potential treatment option for PDS. We will conduct this large trial to determine the efficacy of acupuncture versus sham acupuncture for PDS. A total of 280 eligible patients who meet the Rome IV criteria for PDS will be randomly...

Promoter hypomethylation mediated upregulation of MicroRNA-10b-3p targets FOXO3 to promote the progression of esophageal squamous cell carcinoma (ESCC)

Esophageal cancer is a high incident cancer worldwide with poor survival and limited therapeutic options. Alterations of microRNAs are common in cancers, and many of these micro RNAs are potential therapeutic and diagnostic targets to treat these cancers. miR-10b-3p located in chromosome region 2q31.1, and its expression is frequently increased in esophageal squamous cell...

SIGIRR participates in negative regulation of LPS response and tolerance in human bladder epithelial cells

Background The innate immune response of urinary tract is critically important in the defense to microbial attack. Toll-like receptor 4 (TLR4) controls initial mucosal response to uropathogenic Escherichia coli (UPEC). However, excessive and dysfunctional TLR signaling may result in severe inflammation and inappropriate tissue damage. Previous studies have demonstrated that...

Seminal fluid protein genes of the brown planthopper, Nilaparvata lugens

Background Seminal fluid proteins (SFPs) are produced mainly in the accessory gland of male insects and transferred to females during mating, in which they induce numerous physiological and post-mating behavioral changes. The brown plant hopper (BPH), Nilaparvata lugens, is an economically important hemipterous pest of rice. The behavior and physiology of the female of this...

Interactions with the MC4R rs17782313 variant, mental stress and energy intake and the risk of obesity in Genome Epidemiology Study

Xin Zhang 0 Hyun Seok Jin 1 Hye Ja Lee 4 Yong Hyun Lee 3 0 Department of Food and Nutrition, Obesity/Diabetes Research Center, Hoseo University , 165 Sechul-Ri, BaeBang-Yup, Asan-Si, Chung Nam-Do 336

A vaccine with Aβ oligomer-specific mimotope attenuates cognitive deficits and brain pathologies in transgenic mice with Alzheimer’s disease

Background β-Amyloid peptide (Aβ) oligomers are initial factors used to induce Alzheimer’s disease (AD) development, and Aβ monomers have normal physiological function. The antibodies or vaccines against Aβ monomers have serious problems, such as side effects and low curative effects. Therefore, it is essential to specifically target Aβ oligomers rather than monomers for the...

TAGLN2 is a candidate prognostic biomarker promoting tumorigenesis in human gliomas

Transgelin-2 (TAGLN2) is a member of the calponin family of actin-bundling proteins that is involved in the regulation of cell morphology, motility, and cell transformation. Here, the clinical significance and potential function of TAGLN2 in malignant gliomas were investigated. Molecular and clinical data was obtained from The Cancer Genome Atlas (TCGA) database. Gene ontology...

Small lung lesions invisible under fluoroscopy are located accurately by three-dimensional localization technique on chest wall surface and performed bronchoscopy procedures to increase diagnostic yields

Background Nowadays, small peripheral pulmonary lesions (PPLs) are frequently detected and the prognosis of lung cancer depends on the early diagnosis. Because of the high fee and requiring specialized training, many advanced techniques are not available in many developing countries and rural districts. Methods Three sets of opaque soft copper wires visible under the fluoroscopy...

The accuracy of presepsin (sCD14-ST) for the diagnosis of sepsis in adults: a meta-analysis

Introduction The early diagnosis of sepsis remains a challenge. Recently, soluble cluster of differentiation 14 subtype (sCD14-ST), also known as presepsin, has been identified as a potential biomarker of sepsis. We performed a meta-analysis to assess the diagnostic accuracy of presepsin for sepsis in patients with systemic inflammation. Methods We systematically searched the...

Elevated resting heart rate predisposes metabolic syndrome in women rather than in men: a 15-year prospective study

Background Increasing evidences have indicated that there are gender differences in the prevalence of metabolic syndrome(MS), but the mechanism is uncertain. Methods A total of 711 subjects aged 35–65 years accepted health examinations both in 1992 and 2007. Since 114 subjects had MS and 7 had heart disease at baseline, they were excluded from the analysis. Therefore, 590...

Systematic review and meta-analysis of totally laparoscopic versus laparoscopic assisted distal gastrectomy for gastric cancer

Background Totally laparoscopic distal gastrectomy (TLDG) has been developed in the hope of improving surgical quality and overcoming the limitations of conventional laparoscopic assisted distal gastrectomy (LADG) for gastric cancer. The aim of this study was to determine the extent of evidence in support of these ideals. Methods A systematic review of the two operation types...

Gastric tonometry guided therapy in critical care patients: a systematic review and meta-analysis

Introduction The value of gastric intramucosal pH (pHi) can be calculated from the tonometrically measured partial pressure of carbon dioxide ( P C O 2 ) in the stomach and the arterial bicarbonate content. Low pHi and increase of the difference between gastric mucosal and arterial P C O 2 ( P C O 2 gap) reflect splanchnic hypoperfusion and are good indicators of poor prognosis...

MiR-133a is downregulated in non-small cell lung cancer: a study of clinical significance

). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Dong Lan and Xin Zhang contributed equally to this paper. 1. Lee PN , Forey

MiR-133a is downregulated in non-small cell lung cancer: a study of clinical significance

in the malignant phenotype of NSCLC cell lines. Notes Dong Lan and Xin Zhang contributed equally to this work. Declarations Acknowledgements The study was supported by the Fund of Guangxi ... and analysis, decision to publish, or preparation of the manuscript. Dong Lan and Xin Zhang contributed equally to this paper. Competing interests The authors declare that they have no competing

Intralesional injection treatment of hypertrophic scars and keloids: a systematic review regarding outcomes

BackgroundThe aim of this review was to explore the existing body of literature focusing on the intralesional treatments of keloids and hypertrophic scars.MethodsA comprehensive systematic review of related articles was conducted across multiple databases. Article selection was limited to those published in the English language between 1950 and 2014. Search terms for the on-line...

Different tenogenic differentiation capacities of different mesenchymal stem cells in the presence of BMP-12

Background Mesenchymal stem cells (MSCs) are regarded as a promising cell-based therapeutic tool for tendon repair. This study aimed to compare the different tenogenic differentiation capacities of the three types of MSCs in the presence of bone morphogenic protein 12 (BMP-12). Methods MSCs were isolated from rat bone marrow (BM), inguinal adipose tissue (AD), and synovium (SM...

Human polyomavirus type six in respiratory samples from hospitalized children with respiratory tract infections in Beijing, China

Background HPyV6 is a novel human polyomavirus (HPyV), and neither its natural history nor its prevalence in human disease is well known. Therefore, the epidemiology and phylogenetic status of HPyV6 must be systematically characterized. Methods The VP1 gene of HPyV6 was detected with an established TaqMan real-time PCR from nasopharyngeal aspirate specimens collected from...