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Search: authors:"Xin Zhang"

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Deficient FGF signaling causes optic nerve dysgenesis and ocular coloboma

Zhigang Cai Chenqi Tao Hongge Li Raj Ladher Noriko Gotoh Gen-Sheng Feng Fen Wang Xin Zhang SUMMARY FGF signaling plays a pivotal role in eye development. Previous studies using in vitro chick models

Frs2α and Shp2 signal independently of Gab to mediate FGF signaling in lens development

Fibroblast growth factor (FGF) signaling requires a plethora of adaptor proteins to elicit downstream responses, but the functional significances of these docking proteins remain controversial. In this study, we used lens development as a model to investigate Frs2α and its structurally related scaffolding proteins, Gab1 and Gab2, in FGF signaling. We show that genetic ablation of...