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Absorption Characteristics of Combination Medication of Realgar and Indigo Naturalis: In Vitro Transport across MDCK-MDR1 Cells and In Vivo Pharmacokinetics in Mice after Oral Administration

Realgar and indigo naturalis are clinically combined to treat varieties of leukemia. Exploring the drug-drug interactions might be beneficial to find active substances and develop new targeted drugs. This study aimed at exploring the change of arsenic concentration in mice and across MDCK-MDR1 cells and the cytotoxicity on K562 cells when realgar and indigo naturalis were...

Effect of Qufengtongluo Decoction on PI3K/Akt Signaling Pathway in the Kidney of Type 2 Diabetes Mellitus Rat (GK Rat) with Diabetic Nephropathy

Wen-Jing Wu,2 Zi-Long Shen,3 Hua Zhang,1 Xu Jia,4 Xue-Min Huang,5 Ya-Xin Zhang,1 Jin-Xi Zhao,1 Shi-Dong Wang,1 Mian Jia,6 and Yu-Ting Zhang4 1Section II of Endocrinology & Nephropathy, Department of

Effect of Qufengtongluo Decoction on PI3K/Akt Signaling Pathway in the Kidney of Type 2 Diabetes Mellitus Rat (GK Rat) with Diabetic Nephropathy

Wen-Jing Wu,2 Zi-Long Shen,3 Hua Zhang,1 Xu Jia,4 Xue-Min Huang,5 Ya-Xin Zhang,1 Jin-Xi Zhao,1 Shi-Dong Wang,1 Mian Jia,6 and Yu-Ting Zhang4 1Section II of Endocrinology & Nephropathy, Department of

Effect of Electroacupuncture on Cell Apoptosis and ERK Signal Pathway in the Hippocampus of Adult Rats with Cerebral Ischemia-Reperfusion

,1 Xin Zhang,2 and Xiao Lan1 1School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong Province 510515, China 2College of Acupuncture, Moxibustion, and Tuina, Hunan ... purchased animal and material instruments. Jiao Wang and Chun Li analyzed data. Chunxiao Wu wrote the paper. Xiuhong Xu operated the acupuncture. Xin Zhang and Xiao Lan ensured the integrity of the data

Effect of Electroacupuncture on Cell Apoptosis and ERK Signal Pathway in the Hippocampus of Adult Rats with Cerebral Ischemia-Reperfusion

,1 Xin Zhang,2 and Xiao Lan1 1School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong Province 510515, China 2College of Acupuncture, Moxibustion, and Tuina, Hunan ... purchased animal and material instruments. Jiao Wang and Chun Li analyzed data. Chunxiao Wu wrote the paper. Xiuhong Xu operated the acupuncture. Xin Zhang and Xiao Lan ensured the integrity of the data

Suan Zao Ren Tang in Combination with Zhi Zi Chi Tang as a Treatment Protocol for Insomniacs with Anxiety: A Randomized Parallel-Controlled Trial

Insomnia is a serious worldwide health problem that is often comorbid with anxiety. The purpose of the present study was to evaluate the efficacy of a Chinese formula containing Suan Zao Ren Tang (SZRT) and Zhi Zi Chi Tang (ZZCT; SZR-ZZC) for improving sleep quality and anxiety states with four indices of Polysomnography (PSG), the Insomnia Severity Index (ISI), the Pittsburgh...

Suan Zao Ren Tang in Combination with Zhi Zi Chi Tang as a Treatment Protocol for Insomniacs with Anxiety: A Randomized Parallel-Controlled Trial

Insomnia is a serious worldwide health problem that is often comorbid with anxiety. The purpose of the present study was to evaluate the efficacy of a Chinese formula containing Suan Zao Ren Tang (SZRT) and Zhi Zi Chi Tang (ZZCT; SZR-ZZC) for improving sleep quality and anxiety states with four indices of Polysomnography (PSG), the Insomnia Severity Index (ISI), the Pittsburgh...

Chai-Qin-Cheng-Qi Decoction and Carbachol Improve Intestinal Motility by Regulating Protein Kinase C-Mediated Ca2

Chen-Long Zhang,1 Zi-Qi Lin,1 Rui-Jie Luo,1 Xiao-Xin Zhang,1 Jia Guo,1 Wei Wu,1 Na Shi,1 Li-Hui Deng,1 Wei-Wei Chen,1 Xiao-Ying Zhang,1,2 Shameena Bharucha,2 Wei Huang,1,2 Robert Sutton,2 John A. Windsor

Chai-Qin-Cheng-Qi Decoction and Carbachol Improve Intestinal Motility by Regulating Protein Kinase C-Mediated Ca2

Chen-Long Zhang,1 Zi-Qi Lin,1 Rui-Jie Luo,1 Xiao-Xin Zhang,1 Jia Guo,1 Wei Wu,1 Na Shi,1 Li-Hui Deng,1 Wei-Wei Chen,1 Xiao-Ying Zhang,1,2 Shameena Bharucha,2 Wei Huang,1,2 Robert Sutton,2 John A. Windsor

Monitoring the Effects of Acupoint Antioxidant Intervention by Measuring Electrical Potential Difference along the Meridian

Previous studies suggest that superoxide anions are possibly traveling along acupuncture meridians. The electrical potential difference (EPD) between acupoints may be related to the movement. To test the above hypothesis, we conducted a study investigating the effects of acupoint antioxidant interventions on the meridian EPD. Firstly, ST39 (L) and ST44 (L) were screened out for...

Aβ Damages Learning and Memory in Alzheimer’s Disease Rats with Kidney-Yang Deficiency

Previous studies demonstrated that Alzheimer’s disease was considered as the consequence produced by deficiency of Kidney essence. However, the mechanism underlying the symptoms also remains elusive. Here we report that spatial learning and memory, escape, and swimming capacities were damaged significantly in Kidney-yang deficiency rats. Indeed, both hippocampal Aβ40 and 42...

Reliability and External Validity of AMSTAR in Assessing Quality of TCM Systematic Reviews

Objective. The aim of this study is to measure the reliability and external validity of AMSTAR by applying it to a sample of TCM systematic reviews. Study Design and Methods. We tested the agreement, reliability, construct validity, and feasibility of AMSTAR through comparisons with OQAQ. Statistical analyses were performed by using SPSS 13.0. Results. A random of sample with 41...

NMDA Receptors of Gastric-Projecting Neurons in the Dorsal Motor Nucleus of the Vagus Mediate the Regulation of Gastric Emptying by EA at Weishu (BL21)

: Gerhard Litscher Copyright © 2012 Xin Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and

NMDA Receptors of Gastric-Projecting Neurons in the Dorsal Motor Nucleus of the Vagus Mediate the Regulation of Gastric Emptying by EA at Weishu (BL21)

: Gerhard Litscher Copyright © 2012 Xin Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and