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GJB2 mutation spectrum in 2063 Chinese patients with nonsyndromic hearing impairment

Yongyi Yuan 17 Xin Liu 17 Deliang Huang 17 Dongyang Kang 17 Xin Zhang 17 Huijun Yuan 17 Kun Yao 21 Jinsheng Hao 20 Jia He 19 Yong He 18 Youqin Wang 23 Qing Ye 23 Youjun Yu 22 Hongyan Lin 16

Inhibition of cellular transformation by triphenylmethane: a novel chemopreventive agent

Triphenyhuethane (TPM) was found to inhibit 3-methyl-cholanthrene-induced neoplastic transformation of 10T1/2 cells in a dose-dependent manner (ED50 = 2.8 μM). This activity was independent of any effect on intercellular communication and did not appear to be directly related to the general antioxidant properties of TPM as measured by cellular thiobarbituric acid-reactive...

New Perspectives on Host-Parasite Interplay by Comparative Transcriptomic and Proteomic Analyses of Schistosoma japonicum

Schistosomiasis remains a serious public health problem with an estimated 200 million people infected in 76 countries. Here we isolated ~ 8,400 potential protein-encoding cDNA contigs from Schistosoma japonicum after sequencing circa 84,000 expressed sequence tags. In tandem, we undertook a high-throughput proteomics approach to characterize the protein expression profiles of a...

Genome-Wide Association Study Identifies ALDH7A1 as a Novel Susceptibility Gene for Osteoporosis

Zhang Qi Zhou Chuan Qiu Shan-Shan Dong Xiang-Hong Xu Yan-Fang Guo Xue-Zhen Zhu Shan-Lin Liu Xiang-Li Wang Xi Li Yi Luo Li-Shu Zhang Meng Li Jin-Tang Wang Ting Wen Betty Drees James Hamilton Christopher J

Comparing gene discovery from Affymetrix GeneChip microarrays and Clontech PCR-select cDNA subtraction: a case study

Background Several high throughput technologies have been employed to identify differentially regulated genes that may be molecular targets for drug discovery. Here we compared the sets of differentially regulated genes discovered using two experimental approaches: a subtracted suppressive hybridization (SSH) cDNA library methodology and Affymetrix GeneChip® technology. In this...

Up-regulation of DLK1 as an imprinted gene could contribute to human hepatocellular carcinoma

Dysregulation of a genomic imprinting gene can contribute to carcinogenesis. Here, delta-like 1 homolog (Drosophila) (DLK1), a paternally expressed gene, was found to be significantly up-regulated in 60 (73.2%) of a total of 82 hepatocellular carcinoma (HCC) specimens using reverse transcription–polymerase chain reaction. In addition, immunohistochemistry staining was performed...

Dietary Vitamin C Intake and Lung Function in Rural China

The relation between dietary vitamin C intake and pulmonary function was investigated in a cross-sectional study carried out in 69 counties in rural China in 1989. Within each of the 69 counties, 120 subjects aged 35–64 years were identified using a three-stage random clustering procedure. Each subject underwent pulmonary function testing, completed a detailed questionnaire, and...

Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations

Fan Yang Yi-Xin Zhang Wei Li Gu-Yan Zheng Hanbin Cui Xiaomin Chen Zhiming Zhu Hongbo He Birong Dong Xianming Mo Yi Zeng Xiao-Li Tian FOXO1A and FOXO3A are two members of the FoxO family. FOXO3A has

A novel form of cell type-specific partial IFN-γR1 deficiency caused by a germ line mutation of the IFNGR1 initiation codon

Xiao-Fei Kong Guillaume Vogt Ariane Chapgier Christophe Lamaze Jacinta Bustamante Carolina Prando Anny Fortin Anne Puel Jacqueline Feinberg Xin-Xin Zhang Pauline Gonnord Ulla M. Pihkala-Saarinen

Silencing the epidermal growth factor receptor gene with RNAi may be developed as a potential therapy for non small cell lung cancer

Lung cancer has emerged as a leading cause of cancer death in the world. Non-small cell lung cancer (NSCLC) accounts for 75–80% of all lung cancers. Current therapies are ineffective, thus new approaches are needed to improve the therapeutic ratio. Double stranded RNA (dsRNA) -mediated RNA interference (RNAi) has shown promise in gene silencing, the potential of which in...

High-Resolution Analyses of Human Leukocyte Antigens Allele and Haplotype Frequencies Based on 169,995 Volunteers from the China Bone Marrow Donor Registry Program

Zhi-Xin Zhang 0 Jian- Ping Cai 0 0 Editor: Valli De Re, Centro di Riferimento Oncologico, IRCCS National Cancer Institute , ITALY hematopoietic malignant diseases and numerous other disorders. High

Higher percentage of CD133+ cells is associated with poor prognosis in colon carcinoma patients with stage IIIB

Background Cancer stem cell model suggested that tumor progression is driven by the overpopulation of cancer stem cells and eradicating or inhibiting the symmetric division of cancer stem cells would become the most important therapeutic strategy. However, clinical evidence for this hypothesis is still scarce. To evaluate the overpopulation hypothesis of cancer stem cells the...

Evidence of a Relationship Between Infant Birth Weight and Later Diabetes and Impaired Glucose Regulation in a Chinese Population


Clinical and molecular characterization of Wilson's disease in China: identification of 14 novel mutations

Background Wilson's disease (WND) is a rare autosomal recessive disorder. Here we have evaluated 62 WND cases (58 probands) from the Chinese Han population to expand our knowledge of ATP7B mutations and to more completely characterize WND in China. Methods The coding and promoter regions of the ATP7B gene were analyzed by direct sequencing in 62 Chinese patients (58 probands...

Genome-wide association study suggested copy number variation may be associated with body mass index in the Chinese population

Life Science and Technology, Xi’an Jiaotong University, Xi’an, Shanxi, PR ChinaTie-Lin Yang, Yan Guo, Yuan Chen, Feng Pan, Zhi-Xin Zhang, Shan-Shan Dong, Xiang-Hong Xu & Hong-Wen DengSchool of Medicine ... for Zhi-Xin Zhang in:Nature Research journals • PubMed • Google ScholarSearch for Shan-Shan Dong in:Nature Research journals • PubMed • Google ScholarSearch for Xiang-Hong Xu in:Nature Research journals

BAFF supports human B cell differentiation in the lymphoid follicles through distinct receptors

B cell-activating factor of the tumor necrosis factor family (BAFF/BLys) plays a critical role in B cell survival and immune responses through its three receptors: BAFF receptor (BAFF-R/BR3), transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) and B cell maturation antigen (BCMA). Using specific antibodies, we have investigated the expression of...

Chemokine receptor 7 activates phosphoinositide-3 kinase-mediated invasive and prosurvival pathways in head and neck cancer cells independent of EGFR

Chemokine receptor 7 (CCR7) upregulation, which mediates immune cell survival and migration to lymph nodes, has recently been associated with nodal metastasis of squamous cell carcinoma of the head and neck (SCCHN). However, the mechanism of CCR7 in tumor progression, its downstream signaling mediators, and interactions with other pathways contributing to metastasis of SCCHN have...

Apparent gas-phase acidities of multiply protonated peptide ions: Ubiquitin, insulin B, and renin substrate

The gas-phase deprotonation reactions of multiply protonated bovine ubiquitin, insulin chain B, and renin substrate tetradecapeptide ions have been studied in a Fourier transform ion cyclotron resonance mass spectrometer coupled with an external electrospray source. Rate constants were measured for the reactions of these peptide ions with a series of reference compounds of known...

Identification of alternatively spliced mRNA variants related to cancers by genome-wide ESTs alignment

Several databases have been published to predict alternative splicing of mRNAs by analysing the exon linkage relationship by alignment of expressed sequence tags (ESTs) to the genome sequence; however, little effort has been made to investigate the relationship between cancers and alternative splicing. We developed a program, Alternative Splicing Assembler (ASA), to look for...

Ten cities cross-sectional questionnaire survey of children asthma and other allergies in China

Asthma, rhinitis and eczema (allergic or non-allergic) have increased throughout the world during the last decades, especially among children. Changes in the indoor environment are suspected to be important causes. China has experienced a dramatic change in indoor environmental exposures during the past two decades. However, such changes and their associations with children’s...