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11 papers found.
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Identification of transthyretin as a novel interacting partner for the δ subunit of GABAA receptors

Contributions Conceptualization: Li Zhou, Gong Chen. Data curation: Li Zhou, Xin Tang, Xinyi Li, Yuting Bai. Formal analysis: Li Zhou, Xin Tang, Xinyi Li. Funding acquisition: Gong Chen. Investigation: Li ... Zhou, Xinyi Li, Yuting Bai, Gong Chen. Methodology: Li Zhou, Xin Tang, Yuting Bai. Project administration: Li Zhou, Gong Chen. Resources: Li Zhou, Xinyi Li, Joel N. Buxbaum, Gong Chen. Software: Li

Naturally occurring antibodies isolated from PD patients inhibit synuclein seeding in vitro and recognize Lewy pathology

Deposition of α-synuclein into Lewy bodies and Lewy neurites is the hallmark of Parkinson’s disease (PD). It is hypothesized that α-synuclein pathology spreads by a “prion-like” mechanism (i.e., by seeded aggregation or templated misfolding). Therefore, various extracellular α-synuclein conformers and/or posttranslational modifications may serve as biomarkers of disease or...

Smoking, obstructive sleep apnea syndrome and their combined effects on metabolic parameters: Evidence from a large cross-sectional study

Liu Yunyan Xia Yiqun Fu Xinyi Li Yingjun Qian Jianyin Zou HongliangYi Jian Guan OPEN Published: xx xx xxxx Metabolic disorders have been separately associated with obstructive sleep apnea syndrome

Large manipulative experiments revealed variations of insect abundance and trophic levels in response to the cumulative effects of sheep grazing

Xinghu Qin Yong Ding Jun Hong Guilin Du Xinyi Li Wenyuan Gao Zhuoran Zhang Guangjun Wang Ning Wang Zehua Zhang OPEN Published: xx xx xxxx Livestock grazing can affect insects by altering habitat quality

Neural Hyperactivity of the Central Auditory System in Response to Peripheral Damage

It is increasingly appreciated that cochlear pathology is accompanied by adaptive responses in the central auditory system. The cause of cochlear pathology varies widely, and it seems that few commonalities can be drawn. In fact, despite intricate internal neuroplasticity and diverse external symptoms, several classical injury models provide a feasible path to locate responses to...

Generalization of interpolation DFT algorithms and frequency estimators with high image component interference rejection

This paper focuses on the problem of frequency estimation of noise-contaminated sinusoidal. A basic tool to solve this problem is the interpolated discrete Fourier transform (DFT) algorithms, in which the influences of the spectral leakage from negative frequency are often neglected, resulting in significant errors in estimation when the signals contained small cycles. In this...

Characteristic analysis of prolactin and its receptor genes from Rana chensinensis and expression pattern during metamorphosis

In order to explore the role of prolactin (PRL) and the prolactin receptor (PRLR) during metamorphosis of amphibians, both cDNAs from the Chinese brown frog Rana chensinensis were identified. A PRL cDNA consisting of a 645-bp open reading frame and a PRLR cDNA consisting of a 1854-bp open reading frame were obtained. The amino acid sequence analysis indicated that there were 2...

miR-130a can predict response to temozolomide in patients with glioblastoma multiforme, independently of O6-methylguanine-DNA methyltransferase

Background Currently, O6-methylguanine-DNA methyltransferase(MGMT) promoter methylation is the most convincing predictive biomarker for temozolomide (TMZ) response in patients with glioblastoma multiforme (GBM). However, technical obstacles prevent this biomarker from being applied widely. On the other hand, microRNAs (miRNAs) are easily investigated in the clinical setting using...

Transthyretin and the brain re-visited: Is neuronal synthesis of transthyretin protective in Alzheimer's disease?

Since the mid-1990's a trickle of publications from scattered independent laboratories have presented data suggesting that the systemic amyloid precursor transthyretin (TTR) could interact with the amyloidogenic β-amyloid (Aβ) peptide of Alzheimer's disease (AD). The notion that one amyloid precursor could actually inhibit amyloid fibril formation by another seemed quite far...

Immunological memory to hyperphosphorylated tau in asymptomatic individuals

Several reports have described the presence of antibodies against Alzheimer’s disease-associated hyperphosphorylated forms of tau in serum of healthy individuals. To characterize the specificities that can be found, we interrogated peripheral IgG+ memory B cells from asymptomatic blood donors for reactivity to a panel of phosphorylated tau peptides using a single-cell screening...