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Identification of novel genetic variants for type 2 diabetes, childhood obesity, and their pleiotropic loci

authors contributed equally: Chun-Ping Zeng, Xu Lin AffiliationsDepartment of Endocrinology and Metabolism, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, ChinaChun-Ping Zeng, Lin ... journals • PubMed • Google Scholar Search for Xu Lin in:Nature Research journals • PubMed • Google Scholar Search for Cheng Peng in:Nature Research journals • PubMed • Google Scholar Search for Lin Zhou

Role of advanced glycation end products in mobility and considerations in possible dietary and nutritional intervention strategies

approval and consent to participate Not Applicable. Consent for publication All authors have approved the manuscript for publication. Competing interests Professor Xu Lin, one of the authors, is

Mechanically robust stretchable organic optoelectronic devices built using a simple and universal stencil-pattern transferring technology

Stretchable electronic and optoelectronic devices based on controllable ordered buckling structures exhibit superior mechanical stability by retaining their buckling profile without distortion in repeated stretch-release cycles. However, a simple and universal technology to introduce ordered buckling structures into stretchable devices remains a real challenge. Here, a simple and...

Targeting of glutamine transporter ASCT2 and glutamine synthetase suppresses gastric cancer cell growth

PurposeGlutamine (Gln) is essential for the proliferation of most cancer cells, making it an appealing target for cancer therapy. However, the role of Gln in gastric cancer (GC) metabolism is unknown and Gln-targeted therapy against GC remains scarce. The aim of this study was to investigate the relevance of Gln in GC growth and targeting.MethodsExpression of Gln transporter...

Prognostic values of red blood cell distribution width, platelet count, and red cell distribution width-to-platelet ratio for severe burn injury

Guo April Peszel Sheng Liu Fei Wang Ye-Xiang Sun Yong-Jie Wang Xu-Lin Chen OPEN Published: xx xx xxxx Red blood cell distribution width (RDW), platelet count (PLT), and a RDW-to-PLT ratio (RPR) have

Supramolecular polymerization of hydrogen-bonded rosettes with anthracene chromophores: regioisomeric effect on nanostructures

Two regioisomeric barbituric acid compounds possessing (phenylethynyl) anthracene cores and tridodecyloxy phenyl units were synthesized. UV–Vis spectroscopic studies showed that the two compounds self-assemble by a cooperative mechanism in methylcyclohexane (MCH) with different stacking arrangements of the π-conjugated core, which leads to distinct aggregation-induced color...

Deubiquitylation of hepatitis B virus X protein (HBx) by ubiquitin-specific peptidase 15 (USP15) increases HBx stability and its transactivation activity

Chen Xinjian Lin Yun-Li Wu Xu Lin OPEN Hepatitis B virus X protein (HBx) plays important roles in viral replication and the development of hepatocellular carcinoma. HBx is a rapid turnover protein and

H3K27 acetylation activated-long non-coding RNA CCAT1 affects cell proliferation and migration by regulating SPRY4 and HOXB13 expression in esophageal squamous cell carcinoma

Recently, long non-coding RNAs (lncRNAs) have been shown to have important regulatory roles in human cancer biology. In our study, we found that lncRNA CCAT1, whose expression is significantly increased and is correlated with outcomes in Esophageal Squamous Cell Carcinoma (ESCC). Consecutive experiments confirmed that H3K27-acetylation could activate expression of colon cancer...

Identification of novel genetic loci for osteoporosis and/or rheumatoid arthritis using cFDR approach

and LP P. Drafting manuscript: R Z, HW D, DY L. Revising manuscript content: R Z, DY L, and HW D. Author Contributions Conceptualization: Hong-Wen Deng. Data curation: Rou Zhou, Xu Lin, Xia-Fang Wang ... , Yuan-Cheng Chen, Chun-Ping Zeng, Jun Min Lu, Zeng-Xing Ao, Lin-Ping Peng, Hong-Wen Deng. Formal analysis: Rou Zhou, Xu Lin, Hong-Wen Deng. Funding acquisition: Hong-Wen Deng. Methodology: Rou Zhou

1H NMR-Based Analysis of Serum Metabolites in Monocrotaline-Induced Pulmonary Arterial Hypertensive Rats

Aims. To study the changes of the metabolic profile during the pathogenesis in monocrotaline (MCT) induced pulmonary arterial hypertension (PAH). Methods. Forty male Sprague-Dawley (SD) rats were randomly divided into 5 groups (, each). PAH rats were induced by a single dose intraperitoneal injection of 60 mg/kg MCT, while 8 rats given intraperitoneal injection of 1 ml normal...

1H NMR-Based Analysis of Serum Metabolites in Monocrotaline-Induced Pulmonary Arterial Hypertensive Rats

Aims. To study the changes of the metabolic profile during the pathogenesis in monocrotaline (MCT) induced pulmonary arterial hypertension (PAH). Methods. Forty male Sprague-Dawley (SD) rats were randomly divided into 5 groups (, each). PAH rats were induced by a single dose intraperitoneal injection of 60 mg/kg MCT, while 8 rats given intraperitoneal injection of 1 ml normal...

Mendelian randomization estimates of alanine aminotransferase with cardiovascular disease: Guangzhou Biobank Cohort study

Observational studies of the association of alanine aminotransferase (ALT) levels with ischaemic heart disease (IHD) and cardiovascular disease (CVD) risk factors are inconsistent, probably because of confounding and reverse causality. Mendelian randomization (MR) provides less confounded results. We used MR analysis to assess the associations of ALT (U/L) with IHD, diabetes and...

High-fidelity self-assembly pathways for hydrogen-bonding molecular semiconductors

The design of molecular systems with high-fidelity self-assembly pathways that include several levels of hierarchy is of primary importance for the understanding of structure-function relationships, as well as for controlling the functionality of organic materials. Reported herein is a high-fidelity self-assembly system that comprises two hydrogen-bonding molecular semiconductors...

Methylprednisolone attenuates lipopolysaccharide-induced Fractalkine expression in kidney of Lupus-prone MRL/lpr mice through the NF-kappaB pathway

Background Fractalkine (FKN) is involved in the occurrence and development of human lupus nephritis. It is known to be upregulated by lipopolysaccharide (LPS) as a stimulus in vivo. MRL/lpr mice have been used as an in vivo model to study lupus nephritis. Methylprednisolone (MP) is used widely in the clinical treatment of progressive glomerular diseases such as lupus nephritis...

As-grown graphene/copper nanoparticles hybrid nanostructures for enhanced intensity and stability of surface plasmon resonance

The transfer-free fabrication of the high quality graphene on the metallic nanostructures, which is highly desirable for device applications, remains a challenge. Here, we develop the transfer-free method by direct chemical vapor deposition of the graphene layers on copper (Cu) nanoparticles (NPs) to realize the hybrid nanostructures. The graphene as-grown on the Cu NPs permits...

Hessian-Regularized Co-Training for Social Activity Recognition

Co-training is a major multi-view learning paradigm that alternately trains two classifiers on two distinct views and maximizes the mutual agreement on the two-view unlabeled data. Traditional co-training algorithms usually train a learner on each view separately and then force the learners to be consistent across views. Although many co-trainings have been developed, it is quite...

Current understanding of tyrosine kinase BMX in inflammation and its inhibitors

Tec family kinases, which include tyrosine kinase expressed in hepatocellular carcinoma (TEC), Bruton’s tyrosine kinase (BTK), interleukin (IL)-2-inducible T-cell kinase (ITK), tyrosine-protein kinase (TXK), and bone marrow tyrosine kinase on chromosome X (BMX), are the second largest group of non-receptor tyrosine kinases and have a highly conserved carboxyl-terminal kinase...

Association of a Human FABP1 Gene Promoter Region Polymorphism with Altered Serum Triglyceride Levels

Liver fatty acid-binding protein (L-FABP), also known as fatty acid-binding protein 1 (FABP1), is a key regulator of hepatic lipid metabolism. Elevated FABP1 levels are associated with an increased risk of cardiovascular disease (CVD) and metabolic syndromes. In this study, we examine the association of FABP1 gene promoter variants with serum FABP1 and lipid levels in a Chinese...