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2-Deoxy-D-glucose enhances TRAIL-induced apoptosis in human melanoma cells through XBP-1-mediated up-regulation of TRAIL-R2

Background Past studies have shown that sensitivity of melanoma cells to TRAIL-induced apoptosis is largely correlated with the expression levels of TRAIL death receptors on the cell surface. However, fresh melanoma isolates and melanoma tissue sections express generally low levels of death receptors for TRAIL. The clinical potential of TRAIL in the treatment of melanoma may...

24-hour-restraint stress induces long-term depressive-like phenotypes in mice

-term depressive-like phenotypes in mice Xixia Chu Ying Zhou Zhiqiang Hu Jingyu Lou Wei Song Jing Li Xiao Liang Chen Chen Shuai Wang BeimengYang Lei Chen Xu Zhang Jinjing Song Yujie Dong Shiqing Chen Lin

5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers

DNA modifications such as 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) are epigenetic marks known to affect global gene expression in mammals. Given their prevalence in the human genome, close correlation with gene expression and high chemical stability, these DNA epigenetic marks could serve as ideal biomarkers for cancer diagnosis. Taking advantage of a highly...

A Chitin-Like Component on Sclerotic Cells of Fonsecaea pedrosoi Inhibits Dectin-1-Mediated Murine Th17 Development by Masking β-Glucans

Fonsecaea pedrosoi (F. pedrosoi), a major agent of chromoblastomycosis, has been shown to be recognized primarily by C-type lectin receptors (CLRs) in a murine model of chromoblastomycosis. Specifically, the β-glucan receptor, Dectin-1, mediates Th17 development and consequent recruitment of neutrophils, and is evidenced to have the capacity to bind to saprophytic hyphae of F...

A Multicenter, Randomized Clinical Trial Comparing the Three-Weekly Docetaxel Regimen plus Prednisone versus Mitoxantone plus Prednisone for Chinese Patients with Metastatic Castration Refractory Prostate Cancer

Purpose To explore the feasibility and efficacy of docetaxel plus prednisone for Chinese population with metastatic castration refractory prostate cancer (mCRPC). Patients and methods A total of 228 patients recruited from 15 centers were randomized to receive 10 cycles of D3P arm (docetaxel: 75 mg/m2, intravenous infusion, every three weeks; Prednisone 10mg orally given daily...

A New Control Method for Second-Order Multiple Models Control System Based on Global Sliding Mode

Zhang; moc.361@8189891xdz Received 11 January 2018; Revised 23 May 2018; Accepted 28 June 2018; Published 30 July 2018 Academic Editor: Andrzej Swierniak Copyright © 2018 Dan-xu Zhang et al. This is ... Engineering, Air Force Engineering University, Xi’an, China 2Research Center for Evaluation and Argumentation, Academy of Military Sciences, Beijing 100091, China Correspondence should be addressed to Dan-xu

A Systematic Review about the Efficacy and Safety of Tripterygium wilfordii Hook.f. Preparations Used for the Management of Rheumatoid Arthritis

Li,3 Attilio Mucelli,4 Xu Zhang,5 and Xueping Zhou1 1The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, China 2School of Health Economics and Management ... , Nanjing University of Chinese Medicine, Nanjing 210023, China Correspondence should be addressed to Attilio Mucelli; moc.liamg@illecum.oilitta, Xu Zhang; nc.ude.mcujn@uxgnahz, and Xueping Zhou

A Tissue-Specific Scaffold for Tissue Engineering-Based Ureteral Reconstruction

Terminally differentiated somatic cells can rapidly change phenotypes when they are isolated from their native tissue and cultured in vitro. This problem may become a barrier to tissue engineering-based organ reconstruction, which utilizes somatic cells. The present study was designed to validate the feasibility of maintaining the urothelial cell phenotype in a tissue-specific...

A Unique Virulence Gene Occupies a Principal Position in Immune Evasion by the Malaria Parasite Plasmodium falciparum

Mutually exclusive gene expression, whereby only one member of a multi-gene family is selected for activation, is used by the malaria parasite Plasmodium falciparum to escape the human immune system and perpetuate long-term, chronic infections. A family of genes called var encodes the chief antigenic and virulence determinant of P. falciparum malaria. var genes are transcribed in...

A male pheromone-mediated trade-off between female preferences for genetic compatibility and sexual attractiveness in rats

Introduction Chemosensory signals play a vital role in socio-sexual interactions of rodents. Females rely heavily on chemosensory signals to evaluate genetic similarity and quality of potential mates, but their olfactory preferences for these criteria often conflict in mate choice. Results Using two inbred strains of rats, Brown Norway (BB) and Lewis (LL) and their F1 reciprocal...

A motion-classification strategy based on sEMG-EEG signal combination for upper-limb amputees

Background Most of the modern motorized prostheses are controlled with the surface electromyography (sEMG) recorded on the residual muscles of amputated limbs. However, the residual muscles are usually limited, especially after above-elbow amputations, which would not provide enough sEMG for the control of prostheses with multiple degrees of freedom. Signal fusion is a possible...

A new method for noninvasive venous blood oxygen detection

Background Blood oxygen saturation of vein (SvO2) is an important clinical parameter for patient monitoring. However, the existing clinical methods are invasive, expensive, which are also painful for patients. Methods Based on light-absorption, this study describes a new noninvasive SvO2 measurement method by using external stimulation signal to generate cyclical fluctuation...

A new species of Anagyrus (Hymenoptera, Encyrtidae) from Malaysia, parasitoid of Lanceacoccus sp. (Hemiptera, Pseudococcidae)

? [4?, 2? on slides], the same data as holotype (IZCAS). 15?, 3? [2?, 1? on slides], MALAYSIA, Sabah, Mt. Trus Madi, 5?26'27"N; 116?27'0"W, c. 1180m, 3.IV.2017, Xu Zhang rearing from Lanceacoccus sp

A sharp observability inequality for Kirchhoffplate systems with potentials

In this paper, we derive a sharp observability inequality for Kirchhoff plate equations with lower order terms. More precisely, for any T > 0 and suitable boundary observation domains (satisfying the geometric conditions that the multiplier method imposes), we prove an estimate with an explicit observability constant for Kirchhoff plate systems with an arbitrary finite number of...

A treasure reservoir of genetic resource of tea plant (Camellia sinensis) in Dayao Mountain

Components of 29 wild type tea single plants collected from Dayao Mountain, in Guangxi province, South China, were investigated. They included tea polyphenols, free amino acids, catechin, amino acid and alkaloid monomers etc. Genetic diversity and clustering analyses were conducted based on the main biochemical components. Meanwhile, genetic relationships among 6 wild type tea...

AMPK enhances the expression of pancreatic duodenal homeobox-1 via PPARα, but not PPARγ, in rat insulinoma cell line INS-1

). Author contribution Hua GUO performed the research, analyzed the data, and wrote the paper; Shui SUN performed the research, analyzed the data, and wrote the paper; Xu ZHANG and Xiu-juan ZHANG performed

Aberrant expression and potential therapeutic target of lysophosphatidic acid receptor 3 in triple-negative breast cancers

Triple receptor-negative breast cancers (TNBCs) generally have poor prognoses because of the loss of therapeutic targets. As lysophosphatidic acid (LPA) receptor signaling has been shown to affect breast cancer initiation and progression, we try to evaluate the potential roles of LPA receptors in TNBCs. We examined mRNA and protein expressions of LPA receptors 1-3, using...

Accelerated disease progression and robust innate host response in aged SIVmac239-infected Chinese rhesus macaques is associated with enhanced immunosenescence

of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650223, ChinaHong-Yi Zheng, Ming-Xu Zhang, Min Chen, Jin Jiang, Jia-Hao Song, Xiao-Dong Lian, Ren-Rong Tian, Xiao-Liang Zhang, Lin-Tao Zhang ... Science, University of Chinese Academy of Sciences, Kunming, Yunnan, 650204, ChinaMing-Xu Zhang, Min Chen, Jin Jiang, Xiao-Dong Lian & Yong-Tang ZhengInstitute of Health Sciences, Anhui University, Hefei

Activation of Mesenchymal Stem Cells by Macrophages Prompts Human Gastric Cancer Growth through NF-κB Pathway

Accumulating evidence indicate that macrophages activate mesenchymal stem cells (MSCs) to acquire pro-inflammatory phenotype. However, the role of MSCs activated by macrophages in gastric cancer remains largely unknown. In this study, we found that MSCs were activated by macrophages to produce increased levels of inflammatory cytokines. Cell colony formation and transwell...

Adaptive Content Management for UGC Video Delivery in Mobile Internet Era

The demand of storing and transferring user generated content (UGC) has been rapidly growing with the popularization of mobile devices equipped with video recording and playback capabilities. As a typical application of software-defined networks/network functions virtualization-based pervasive communications infrastructure, content delivery networks (CDNs) have been widely...