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Central role of myeloid MCPIP1 in protecting against LPS-induced inflammation and lung injury

Board Grant (to MF). Author information Author notesYong Li, Xuan Huang & Shengping Huang These authors contributed equally to this work. Affiliations Department of Biomedical Science and Shock/Trauma ... Research Center, School of Medicine, University of Missouri-Kansas City, Kansas City, Missouri, MO, USA Yong Li, Xuan Huang, Shengping Huang, Hui He, Tianhua Lei, Christopher J Papasian & Mingui Fu Institute

Algorithm for Target Recognition Based on Interval-Valued Intuitionistic Fuzzy Sets with Grey Correlation

2016 Academic Editor: Anna M. Gil-Lafuente Copyright © 2016 Xuan Huang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use

Algorithm for Target Recognition Based on Interval-Valued Intuitionistic Fuzzy Sets with Grey Correlation

2016 Academic Editor: Anna M. Gil-Lafuente Copyright © 2016 Xuan Huang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use

Capacity evaluation for general practitioners in Pudong new area of Shanghai: an empirical study

Background Building highly qualified General Practitioners (GPs) is key to the development of primary health care. It’s therefore urgent to ensure the GPs’ quality service under the background of the new round of health care system reforms in China. A new model of GP qualification examination was originally implemented in Pudong New Area of Shanghai, China, which aimed to...

The Multiscale Conformation Evolution of the Financial Time Series

Fluctuations of the nonlinear time series are driven by the traverses of multiscale conformations from one state to another. Aiming to characterize the evolution of multiscale conformations with changes in time and frequency domains, we present an algorithm that combines the wavelet transform and the complex network. Based on defining the multiscale conformation using a set of...

The Multiscale Conformation Evolution of the Financial Time Series

Fluctuations of the nonlinear time series are driven by the traverses of multiscale conformations from one state to another. Aiming to characterize the evolution of multiscale conformations with changes in time and frequency domains, we present an algorithm that combines the wavelet transform and the complex network. Based on defining the multiscale conformation using a set of...

Words Analysis of Online Chinese News Headlines about Trending Events: A Complex Network Perspective

Because the volume of information available online is growing at breakneck speed, keeping up with meaning and information communicated by the media and netizens is a new challenge both for scholars and for companies who must address public relations crises. Most current theories and tools are directed at identifying one website or one piece of online news and do not attempt to...

Efficiency of household energy utilization in rural China

This paper calculates energy efficiency and exergy efficiency of household energy utilization in rural China. Provincial energy efficiencies and exergy efficiencies for space heating sector, cooking sector and hot water sector are calculated and analyzed. Result shows that national energy efficiencies in space heating, cooking and hot water sector are 27.43, 15.32 and 13.11...

Cryo-EM structure of SNAP-SNARE assembly in 20S particle

N-ethylmaleimide-sensitive factor (NSF) and α soluble NSF attachment proteins (α-SNAPs) work together within a 20S particle to disassemble and recycle the SNAP receptor (SNARE) complex after intracellular membrane fusion. To understand the disassembly mechanism of the SNARE complex by NSF and α-SNAP, we performed single-particle cryo-electron microscopy analysis of 20S particles...

The Inhibition of Heat Shock Protein 90 Facilitates the Degradation of Poly-Alanine Expanded Poly (A) Binding Protein Nuclear 1 via the Carboxyl Terminus of Heat Shock Protein 70-Interacting Protein

Background Since the identification of poly-alanine expanded poly(A) binding protein nuclear 1 (PABPN1) as the genetic cause of oculopharyngeal muscular dystrophy (OPMD), considerable progress has been made in our understanding of the pathogenesis of the disease. However, the molecular mechanisms that regulate the onset and progression of the disease remain unclear. Results In...

Characterization of the Treg Response in the Hepatitis B Virus Hydrodynamic Injection Mouse Model

Regulatory T cells (Tregs) play an important role in counter-regulating effector T cell responses in many infectious diseases. However, they can also contribute to the development of T cell dysfunction and pathogen persistence in chronic infections. Tregs have been reported to suppress virus-specific T cell responses in hepatitis B virus (HBV) infection of human patients as well...

Generating Moving Average Trading Rules on the Oil Futures Market with Genetic Algorithms

by Haizhong An, Lijun Wang, and Xuan Huang, program development and experiments performance were done by Xiaojia Liu and Lijun Wang, data analysis was done by Haizhong An, Xiaohua Xia, and Xiaoqi Sun ... , paper composition was done by Lijun Wang, Xiaohua Xia, and Xiaojia Liu, and literature retrieval and manuscript editing were done by Xiaojia Liu, Xuan Huang, and Xiaoqi Sun. Acknowledgments This research

Peptide-Mediated Tumor Targeting by a Degradable Nano Gene Delivery Vector Based on Pluronic-Modified Polyethylenimine

Polyethylenimine (PEI) is considered to be a promising non-viral gene delivery vector. To solve the toxicity versus efficacy and tumor-targeting challenges of PEI used as gene delivery vector, we constructed a novel non-viral vector DR5-TAT-modified Pluronic-PEI (Pluronic-PEI-DR5-TAT), which was based on the attachment of low-molecular-weight polyethylenimine (LMW-PEI) to the...

Involvement of soluble scavenger receptor A in suppression of T cell activation in patients with chronic hepatitis B

Background Scavenger receptor A (SRA) is expressed predominantly in phagocytic cells playing an essential role in the host immune defense against invading microorganisms. Our previous study reported the presence of SRA in a soluble form in patients with infection of hepatitis B viruses (HBV). However, the association of soluble SRA with stages of HBV infection and the immune...

Understanding Strategy of Nitrate and Urea Assimilation in a Chinese Strain of Aureococcus anophagefferens through RNA-Seq Analysis

Aureococcus anophagefferens is a harmful alga that dominates plankton communities during brown tides in North America, Africa, and Asia. Here, RNA-seq technology was used to profile the transcriptome of a Chinese strain of A. anophagefferens that was grown on urea, nitrate, and a mixture of urea and nitrate, and that was under N-replete, limited and recovery conditions to...

Challenges to improved therapeutics for metastatic castrate resistant prostate cancer: from recent successes and failures

Men with metastatic castration-resistant prostate cancer (mCRPC) carry poor prognosis despite the use of docetaxel-based regimens which has modest survival benefit shown by randomized clinical trials. Significant progress in the discovery of novel therapeutic agents has been made in the past few years. While sipuleucel-T, cabazitaxel, and abiraterone gained regulatory approval in...

Hepatitis B virus genome replication triggers toll-like receptor 3-dependent interferon responses in the absence of hepatitis B surface antigen

, Joerg Friedrich Schlaak & Ruth BroeringInstitute of Virology, University Hospital at the University Duisburg-Essen, Essen, GermanyMengji Lu, Jia Liu, Xuan Huang, Kathrin Gibbert & Ulf DittmerDepartment of ... Research journals • PubMed • Google ScholarSearch for Xuan Huang in:Nature Research journals • PubMed • Google ScholarSearch for Martin Trippler in:Nature Research journals • PubMed • Google ScholarSearch

Establishment of persistent infection with foot-and-mouth disease virus in BHK-21 cells

Background Foot-and-mouth disease virus (FMDV) is able to cause persistent infection in ruminants besides acute infection and disease. Since the mechanisms of viral persistence and the determining factors are still unknown, in vitro systems help explore and reveal mechanisms of persistence in vivo by providing useful models for the study of RNA genome mutations and evolution...

TCRγδ+CD4−CD8− T Cells Suppress the CD8+ T-Cell Response to Hepatitis B Virus Peptides, and Are Associated with Viral Control in Chronic Hepatitis B

The immune mechanisms underlying failure to achieve hepatitis B e antigen (HBeAg) seroconversion associated with viral control in chronic hepatitis B (CHB) remain unclear. Here we investigated the role of CD4−CD8− T (double-negative T; DNT) cells including TCRαβ+ DNT (αβ DNT) and TCRγδ+ DNT (γδ DNT) cells. Frequencies of circulating DNT cell subsets were measured by flow...

Restored Circulating Invariant NKT Cells Are Associated with Viral Control in Patients with Chronic Hepatitis B

Invariant NKT (iNKT) cells are involved in the pathogenesis of various infectious diseases. However, their role in hepatitis B virus (HBV) infection is not fully understood, especially in human species. In this study, 35 chronic hepatitis B (CHB) patients, 25 inactive carriers (IC) and 36 healthy controls (HC) were enrolled and the proportions of circulating iNKT cells in fresh...