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High NCALD expression predicts poor prognosis of cytogenetic normal acute myeloid leukemia

, Weilong Zhang and Xue He contributed equally to this work Abbreviations AML:  acute myeloid leukemia LSC:  leukemia stem cell CN-AML:  cytogenetic normal acute myeloid leukemia NSCLC:  non

Prognosis value of RBBP8 expression in plasma cell myeloma

contributed equally: Weilong Zhang, Ying Song, Xue He AffiliationsDepartment of Hematology, Lymphoma Research Center, Peking University Third Hospital, Beijing, 100191, ChinaWeilong Zhang, Zuozhen Yang, Ping ... for Ying Song in:Nature Research journals • PubMed • Google Scholar Search for Xue He in:Nature Research journals • PubMed • Google Scholar Search for Xiaoni Liu in:Nature Research journals • PubMed

Bufalin-loaded vitamin E succinate-grafted-chitosan oligosaccharide/RGD conjugated TPGS mixed micelles demonstrated improved antitumor activity against drug-resistant colon cancer

,* Yuxia Yuan,1,* Lin Han,2 Yanyan Qiu,1 Xiaqin Huang,3 Feng Gao,3 Guohua Fan,1 Yixi Zhang,1 Xueyao Tang,1 Xue He,1 Ke Xu,1 Peihao Yin1,4,5 1Interventional Cancer Institute of Chinese Integrative Medicine

The protective effect of PRMT6 overexpression on cigarette smoke extract-induced murine emphysema model

The protective effect of PRMT6 overexpression on cigarette smoke extract-induced murine emphysema model Xue He,1–3 Tiao Li,1–3 Naixin Kang,1–3 Huihui Zeng,1–3 Siying Ren,1–3 Dandan Zong,1–3 Jinhua Li

Genetic polymorphisms analysis of CYP2D6 in the Uygur population

compounds [ 3 ]. It is an important member of the cytochrome oxidase P450 * Correspondence: Xue He and Na He are joint first author. 1Key Laboratory for Basic life science Research of Tibet autonomous ... (2015XZ01G23) and National Natural Science Foundation of China (No. 81560516) Availability of supporting data Other information is provided as supplementary files. Authors’ contributions Xue He and Na He

Subclinical Hypothyroidism and Type 2 Diabetes: A Systematic Review and Meta-Analysis

Background Abundant evidence suggests an association between subclinical hypothyroidism (SCH) and type 2 diabetes mellitus (T2DM), but small sample sizes and inconclusive data in the literature complicate this assertion. Objective We measured the prevalence of SCH in T2DM population, and investigated whether T2DM increase the risk of SCH and whether SCH was associated with...

Stereo Matching Algorithm Based on 2D Delaunay Triangulation

To fulfill the applications on robot vision, the commonly used stereo matching method for depth estimation is supposed to be efficient in terms of running speed and disparity accuracy. Based on this requirement, Delaunay-based stereo matching method is proposed to achieve the aforementioned standards in this paper. First, a Canny edge operator is used to detect the edge points of...

Stereo Matching Algorithm Based on 2D Delaunay Triangulation

Technology, Harbin 150080, China Received 5 January 2015; Accepted 26 May 2015 Academic Editor: Simon X. Yang Copyright © 2015 Xue-he Zhang et al. This is an open access article distributed under the

A New Supervised Over-Sampling Algorithm with Application to Protein-Nucleotide Binding Residue Prediction

Protein-nucleotide interactions are ubiquitous in a wide variety of biological processes. Accurately identifying interaction residues solely from protein sequences is useful for both protein function annotation and drug design, especially in the post-genomic era, as large volumes of protein data have not been functionally annotated. Protein-nucleotide binding residue prediction...

Schistosoma japonicum Soluble Egg Antigens Facilitate Hepatic Stellate Cell Apoptosis by Downregulating Akt Expression and Upregulating p53 and DR5 Expression

Background The induction of hepatic stellate cell (HSC) apoptosis has potential as a potent strategy to diminish the progression of liver fibrosis. Previous studies have demonstrated the ability of soluble egg antigens (SEA) from schistosomes to inhibit HSC activation and to induce apoptosis in vitro. In this study, we aimed to explore the mechanism of SEA-induced apoptosis in...

Expression of microRNA-454 in TGF-β1-stimulated hepatic stellate cells and in mouse livers infected with Schistosoma japonicum

Background In the process of hepatic fibrosis, hepatic stellate cells (HSCs) can be activated by many inflammatory cytokines. The transforming growth factor-β1 (TGF-β1) is one of the main profibrogenic mediators. Recently, some studies have also shown that microRNAs (miRNAs) play essential roles in the progress of liver fibrosis by being involved in the differentiation, fat...

A sex-specific association of common variants of neuroligin genes (NLGN3 and NLGN4X) with autism spectrum disorders in a Chinese Han cohort

Background Synaptic genes, NLGN3 and NLGN4X, two homologous members of the neuroligin family, have been supposed as predisposition loci for autism spectrum disorders (ASDs), and defects of these two genes have been identified in a small fraction of individuals with ASDs. But no such rare variant in these two genes has as yet been adequately replicated in Chinese population and no...

Novel liver-specific cholic acid-cytarabine conjugates with potent antitumor activities: Synthesis and biological characterization

-xue HE 0 Ze-hong MIAO 0 Jing-kang SHEN 0 0 State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203 , China Aim: Cytarabine is an ... China (No 2009ZX09301-001). Author contribution Jing-kang SHEN and Dan-qi CHEN designed research; DanCHEN, Xin WANG, Lin CHEN, Jin-xue HE and Ze-hong MIAO performed research; Dan-qi CHEN and Xin WANG

Characterization of root response to phosphorus supply from morphology to gene analysis in field-grown wheat

The adaptations of root morphology, physiology, and biochemistry to phosphorus supply have been characterized intensively. However, characterizing these adaptations at molecular level is largely neglected under field conditions. Here, two consecutive field experiments were carried out to investigate the agronomic traits and root traits of wheat (Triticum aestivum L.) at six P...

Inappropriate Tuberculosis Treatment Regimens in Chinese Tuberculosis Hospitals

ARTICLEThis investigation of tuberculosis (TB) treatment regimens in 6 TB hospitals in China showed that only 18% of patients with new cases and 9% of patients with retreatment cases were prescribed standard TB treatment regimens. Adherence to treatment guidelines needs to be improved in TB hospitals to control multidrug-resistant TB in China.

Infection control and the burden of tuberculosis infection and disease in health care workers in china: a cross-sectional study

Background Hospitals with inadequate infection control are risky environments for the emergence and transmission of tuberculosis (TB). We evaluated TB infection control practices, and the prevalence of latent TB infection (LTBI) and TB disease and risk factors in health care workers (HCW) in TB centers in Henan province in China. Methods A cross-sectional survey was conducted in...

Infection control and the burden of tuberculosis infection and disease in health care workers in china: a cross-sectional study

Hospitals with inadequate infection control are risky environments for the emergence and transmission of tuberculosis (TB). We evaluated TB infection control practices, and the prevalence of latent TB infection (LTBI) and TB disease and risk factors in health care workers (HCW) in TB centers in Henan province in China. A cross-sectional survey was conducted in 2005. To assess TB...

Follow-Up of Patients with Multidrug Resistant Tuberculosis Four Years after Standardized First-Line Drug Treatment

Background In 2004, an anti-tuberculosis (TB) drug resistance survey in Heilongjiang province, China, enrolled 1574 (79%) new and 421 (21%) retreatment patients. Multi-drug resistant (MDR) TB was detected in 7.2% of new and 30.4% of retreatment patients. All received treatment with standardized first-line drug (FLD) regimens. Methodology/Principal Findings We report treatment...