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35 papers found.
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The Antidiabetic and Antinephritic Activities of Tuber melanosporum via Modulation of Nrf2-Mediated Oxidative Stress in the db/db Mouse

; Accepted 26 June 2018; Published 29 July 2018 Academic Editor: Anderson J. Teodoro Copyright © 2018 Xue Jiang et al. This is an open access article distributed under the Creative Commons Attribution

Impact of spatial organization on a novel auxotrophic interaction among soil microbes

Division (T-6), Center for Nonlinear Studies, Los Alamos, NM, 87545, USASong Feng AuthorsSearch for Xue Jiang in:Nature Research journals • PubMed • Google Scholar Search for Christian Zerfaß in:Nature

A facile doxorubicin-dichloroacetate conjugate nanomedicine with high drug loading for safe drug delivery

A facile doxorubicin-dichloroacetate conjugate nanomedicine with high drug loading for safe drug delivery Conglian Yang,1 Tingting Wu,1 Yuting Qin,1 Yan Qi,1 Yu Sun,1 Miao Kong,1 Xue Jiang,1 Xianya

Disease-related gene module detection based on a multi-label propagation clustering algorithm

Detecting disease-related gene modules by analyzing gene expression data is of great significance. It is helpful for exploratory analysis of the interaction mechanisms of genes under complex disease phenotypes. The multi-label propagation algorithm (MLPA) has been widely used in module detection for its fast and easy implementation. The accuracy of MLPA greatly depends on the...

Erratum: PARP1 promotes gene expression at the post-transcriptional level by modulating the RNA-binding protein HuR

Jiang Xue Tian Xueqing Ba Istvan Boldogh Xianlu Zeng The original version of this Article contained an error in the spelling of post-transcriptional in the title of the paper. This has now been corrected

Three-dimensional broadband acoustic illusion cloak for sound-hard boundaries of curved geometry

Acoustic illusion cloaks that create illusion effects by changing the scattered wave have many potential applications in a variety of scenarios. However, the experimental realization of generating three-dimensional (3D) acoustic illusions under detection of broadband signals still remains challenging despite the paramount importance for practical applications. Here we report the...

PARP1 promotes gene expression at the post-transcriptional level by modulating the RNA-binding protein HuR

Poly(ADP-ribosyl)ation (PARylation) is mainly catalysed by poly-ADP-ribose polymerase 1 (PARP1), whose role in gene transcription modulation has been well established. Here we show that, in response to LPS exposure, PARP1 interacts with the adenylateuridylate-rich element-binding protein embryonic lethal abnormal vision-like 1 (Elavl1)/human antigen R (HuR), resulting in its...

Dropwise Evaporative Cooling of Heated Surfaces with Various Wettability Characteristics Obtained by Nanostructure Modifications

Xiao-long Ouyang 0 Pei-xue Jiang 0 0 Key Laboratory for Thermal Science and Power Engineering of Ministry of Education, Beijing Key Laboratory for CO2 Utilization and Reduction Technology, Department of

Acoustic one-way metasurfaces: Asymmetric Phase Modulation of Sound by Subwavelength Layer

Acoustics, Chinese Academy of Sciences, Beijing 100190, P. R. ChinaJun Yang AuthorsSearch for Xue Jiang in:Nature Research journals • PubMed • Google ScholarSearch for Bin Liang in:Nature Research journals

Specific Tandem 3'UTR Patterns and Gene Expression Profiles in Mouse Thy1+ Germline Stem Cells

A recently developed strategy of sequencing alternative polyadenylation (APA) sites (SAPAS) with second-generation sequencing technology can be used to explore complete genome-wide patterns of tandem APA sites and global gene expression profiles. spermatogonial stem cells (SSCs) maintain long-term reproductive abilities in male mammals. The detailed mechanisms by which SSCs self...

Experimental Investigations on the Dynamic Behaviour of O-Type Wire-Cable Vibration Isolators

A series of periodic loading experiments were carried out on the O-type wire-cable vibration isolators. The isolators were loaded under shear, roll, and tension-compression loadings. When subjected to shear and roll loads, the restoring force-deformation curves generated by the isolators formed symmetric hysteresis loops. However, when the isolators were loaded with tension...

Energy Balance Routing Algorithm Based on Virtual MIMO Scheme for Wireless Sensor Networks

Wireless sensor networks are usually energy limited and therefore an energy-efficient routing algorithm is desired for prolonging the network lifetime. In this paper, we propose a new energy balance routing algorithm which has the following three improvements over the conventional LEACH algorithm. Firstly, we propose a new cluster head selection scheme by taking into...

Dynamic characteristics of Semi-active Hydraulic Engine Mount Based on Fluid-Structure Interaction FEA

A kind of semi-active hydraulic engine mount is studied in this paper. After careful analysis of its structure and working principle, the FEA simulation of it was divided into two cases. One is the solenoid valve is open, so the air chamber connects to the atmosphere, and Fluid-Structure Interaction was used. Another is the solenoid valve is closed, and the air chamber has...

Tight sandstone gas accumulation mechanism and development models

Tight sandstone gas serves as an important unconventional hydrocarbon resource, and outstanding results have been obtained through its discovery both in China and abroad given its great resource potential. However, heated debates and gaps still remain regarding classification standards of tight sandstone gas, and critical controlling factors, accumulation mechanisms, and...

Chemical and Genetic Discrimination of Cistanches Herba Based on UPLC-QTOF/MS and DNA Barcoding

Cistanches Herba (Rou Cong Rong), known as “Ginseng of the desert”, has a striking curative effect on strength and nourishment, especially in kidney reinforcement to strengthen yang. However, the two plant origins of Cistanches Herba, Cistanche deserticola and Cistanche tubulosa, vary in terms of pharmacological action and chemical components. To discriminate the plant origin of...

Pu-Erh Tea Down-Regulates Sterol Regulatory Element-Binding Protein and Stearyol-CoA Desaturase to Reduce Fat Storage in Caenorhaditis elegans

Consumption of Pu-erh has been reported to result in numerous health benefits, but the mechanisms underlying purported weight-loss and lowering of lipid are poorly understood. Here, we used the nematode Caenorhaditis elegans to explore the water extract of Pu-erh tea (PTE) functions to reduce fat storage. We found that PTE down-regulates the expression of the master fat regulator...

CRISPR/Cas9 Promotes Functional Study of Testis Specific X-Linked Gene In Vivo

Mammalian spermatogenesis is a highly regulated multistage process of sperm generation. It is hard to uncover the real function of a testis specific gene in vitro since the in vitro model is not yet mature. With the development of the CRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR-associated 9) system, we can now rapidly generate knockout mouse...

Processing Technology Investigation of Loquat (Eriobotrya japonica) Leaf by Ultra-Performance Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry Combined with Chemometrics

Ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF/MS) and multivariate statistical analysis were used to investigate the processing technology of Loquat (Eriobotrya japonica) leaf (pipaye, PPY). The differences in samples processed using different methods were revealed by unsupervised principal component analysis (PCA). In the scores...

The MDM2–p53–pyruvate carboxylase signalling axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic β-cells

Mitochondrial metabolism is pivotal for glucose-stimulated insulin secretion (GSIS) in pancreatic β-cells. However, little is known about the molecular machinery that controls the homeostasis of intermediary metabolites in mitochondria. Here we show that the activation of p53 in β-cells, by genetic deletion or pharmacological inhibition of its negative regulator MDM2, impairs...

Lys63-linked ubiquitin chain adopts multiple conformational states for specific target recognition

A polyubiquitin comprises multiple covalently linked ubiquitins and recognizes myriad targets. Free or bound to ligands, polyubiquitins are found in different arrangements of ubiquitin subunits. To understand the structural basis for polyubiquitin quaternary plasticity and to explore the target recognition mechanism, we characterize the conformational space of Lys63-linked...