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60 papers found.
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Symmetrical 1-pyrrolidineacetamide showing anti-HIV activity through a new binding site on HIV-1 integrase

Prof Xu SHEN, Prof Hua-liang JIANG and Prof Yun TANG designed research; Li DU performed research, analyzed data and wrote the paper; Ya-xue ZHAO performed the molecular docking; Liu-meng YANG and Yong

Polymorphism of A133S and promoter hypermethylation in Ras association domain family 1A gene (RASSF1A) is associated with risk of esophageal and gastric cardia cancers in Chinese population from high incidence area in northern China

Background The role of tumor suppressor gene RASSF1A in the esophageal and gastric cardia carcinogenesis is still inconclusive. In this study, the polymorphism, promoter methylation and gene expression of RASSF1A were characterized in esophageal squamous cell carcinoma (ESCC) and gastric cardia adenocarcinoma (GCA). Methods We firstly analyzed the prevalence of RASSF1A A133S in a...

Tumor necrosis factor-α attenuates starvation-induced apoptosis through upregulation of ferritin heavy chain in hepatocellular carcinoma cells

Background Tumor microenviroment is characteristic of inflammation, ischemia and starvation of nutrient. TNF-α, which is an extraordinarily pleiotropic cytokine, could be an endogenous tumor promoter in some tumor types. The basic objective of this study was to investigate the effects of TNF-α on the cell viability and apoptosis of hepatocellular carcinoma cells under serum...

Genetic characteristics of soybean resistance to HG type 0 and HG type 1.2.3.5.7 of the cyst nematode analyzed by genome-wide association mapping

Background Soybean cyst nematode (SCN, Heterodera glycines Ichinohe) is one of the most fatal pests of soybean (Glycine max (L.) Merr.) worldwide and causes huge loss of soybean yield each year. Multiple sources of resistance are urgently needed for effective management of SCN via the development of resistant cultivars. The aim of the present study was to investigate the genetic...

Expression quantitative trait loci infer the regulation of isoflavone accumulation in soybean (Glycine max L. Merr.) seed

Background Mapping expression quantitative trait loci (eQTL) of targeted genes represents a powerful and widely adopted approach to identify putative regulatory variants. Linking regulation differences to specific genes might assist in the identification of networks and interactions. The objective of this study is to identify eQTL underlying expression of four gene families...

Toll-like receptor 4 signaling promotes epithelial-mesenchymal transition in human hepatocellular carcinoma induced by lipopolysaccharide

The endotoxin level in the portal and peripheral veins of hepatocellular carcinoma (HCC) patients is higher and lipopolysaccharide (LPS), a cell wall constituent of gram-negative bacteria, has been reported to inhibit tumor growth. However, in this study, we found that LPS-induced toll-like receptor 4 (TLR4) signaling was involved in tumor invasion and survival, and the molecular...

CD133+CXCR4+ colon cancer cells exhibit metastatic potential and predict poor prognosis of patients

Background Colorectal cancer (CRC), which frequently metastasizes to the liver, is one of the three leading causes of cancer-related deaths worldwide. Growing evidence suggests that a subset of cells exists among cancer stem cells. This distinct subpopulation is thought to contribute to liver metastasis; however, it has not been fully explored in CRC yet. Methods Flow cytometry...

Toll-like receptor 4 signaling promotes epithelial-mesenchymal transition in human hepatocellular carcinoma induced by lipopolysaccharide

Background The endotoxin level in the portal and peripheral veins of hepatocellular carcinoma (HCC) patients is higher and lipopolysaccharide (LPS), a cell wall constituent of gram-negative bacteria, has been reported to inhibit tumor growth. However, in this study, we found that LPS-induced toll-like receptor 4 (TLR4) signaling was involved in tumor invasion and survival, and...

Age-related declines in a two-day reference memory task are associated with changes in NMDA receptor subunits in mice

Background C57BL/6 mice show a relationship during aging between NMDA receptor expression and spatial reference memory performance in a 12-day task. The present study was designed to determine if age-related deficits could be detected with a shorter testing protocol and whether these deficits showed a relationship with NMDA receptors. Mice were trained in a reference memory task...

GmGBP1, a homolog of human ski interacting protein in soybean, regulates flowering and stress tolerance in Arabidopsis

Background SKIP is a transcription cofactor in many eukaryotes. It can regulate plant stress tolerance in rice and Arabidopsis. But the homolog of SKIP protein in soybean has been not reported up to now. Results In this study, the expression patterns of soybean GAMYB binding protein gene (GmGBP1) encoding a homolog of SKIP protein were analyzed in soybean under abiotic stresses...

Factors associated with burnout among Chinese hospital doctors: a cross-sectional study

Background Burnout has been a major concern in the field of occupational health. However, there is a paucity of research exploring the factors related to burnout among Chinese doctors. Investigation of these factors is important to improve the health of doctors and the quality of healthcare services in China. Methods The study population consisted of 1,618 registered hospital...

Dysregulated miR-645 affects the proliferation and invasion of head and neck cancer cell

Background and purpose Dysregulated miRNAs play an important role in many malignant tumors. However, elucidating the roles of miRNAs in cancer biology, especially in epithelial cancers, remains an ongoing process. In this study, we identified the differentially expressed miR-645 in the progressing of head and neck squamous cell carcinoma (HNSCC) and investigated its biological...

Inhibition of autophagy increased AGE/ROS-mediated apoptosis in mesangial cells

The aim of our study was to investigate the role of autophagy, a homeostatic process involved in the lysosomal degradation of damaged cell organelles and proteins, in regulating the survival of mesangial cells treated with advanced glycation end products (AGEs). In the present study, AGEs induced mitochondrial depolarization and led to mitochondrial-dependent apoptosis in...

Involvement of proapoptotic genes in autophagic cell death induced by irradiation

, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai 200438, ChinaJianrui Song, Xue Zhao & Lixin WeiDepartment of Cell and Developmental Biology, University of Michigan ... ScholarSearch for Xue Zhao in:Nature Research journals • PubMed • Google ScholarSearch for Yi Feng in:Nature Research journals • PubMed • Google ScholarSearch for Sheng Xu in:Nature Research journals • PubMed

A cross-sectional study of inpatients with late stage of dementia in Southeast China and the associations between biochemical parameters and apolipoprotein E genotypes

,3,* Mei-Fang Chen,3 Zheng Wang,3 Ming-Xue Zhao,3 Bin-Hua Chen,3 Hong-Lei Li1 1Department of Neurology and Research Center of Neurology, The Second Affiliated Hospital of Zhejiang University School of

The Analysis of Braess’ Paradox and Robustness Based on Dynamic Traffic Assignment Models

The investigation of the paradox and robustness about the traffic network is an important branch of the traffic assignment. In this paper, Braess’ paradox and robustness of the dynamic traffic network are analyzed by the dynamic traffic assignment models. In addition, the relationship of total costs with different traffic assignment models is discussed. The results show that the...

Applying Statistical and Complex Network Methods to Explore the Key Signaling Molecules of Acupuncture Regulating Neuroendocrine-Immune Network

,1,3 Zhi-fang Xu,1,3 Xue Zhao,1,3 Jiang Wang,2 Yi Guo,1,4 Kai Li,5 and Sha-sha Ding6 1Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin ... , Xue Zhao, and Kai Li reviewed and edited the manuscript. All authors read and approved the manuscript. Kuo Zhang and Xin-meng Guo contributed equally to this work. Acknowledgments This work was

Applying Statistical and Complex Network Methods to Explore the Key Signaling Molecules of Acupuncture Regulating Neuroendocrine-Immune Network

,1,3 Zhi-fang Xu,1,3 Xue Zhao,1,3 Jiang Wang,2 Yi Guo,1,4 Kai Li,5 and Sha-sha Ding6 1Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin ... , Xue Zhao, and Kai Li reviewed and edited the manuscript. All authors read and approved the manuscript. Kuo Zhang and Xin-meng Guo contributed equally to this work. Acknowledgments This work was

Antihypertensive and Antihypertrophic Effects of Acupuncture at PC6 Acupoints in Spontaneously Hypertensive Rats and the Underlying Mechanisms

, Yu-Xue Zhao, Xiang-Hong Jing, and Xiao-Chun Yu Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, 16 Nanxiaojie, Dongzhimennei, Beijing 100700, China Correspondence ... Wang, and Feng-Yan Lu. Yu-Xue Zhao and Xiang-Hong Jing provided advice on the statistical analyses and data interpretation. Juan-Juan Xin, Xiao-Chun Yu, and Jun-Hong Gao drafted and finalized the paper