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17 papers found.
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Investigation of Induced Unbalance Magnitude on Dynamic Characteristics of High-speed Turbocharger with Floating Ring Bearings

Technology, China. He received his PhD degree from Hunan University, China, in 2015. His research interests include mechanical dynamics, buckling analysis, heat conduction, boundary element method. Xue-Jun Li

Spinal muscular atrophy patient-derived motor neurons exhibit hyperexcitability

• Google ScholarSearch for Zhongwei Du in:Nature Research journals • PubMed • Google ScholarSearch for Xue-Jun Li in:Nature Research journals • PubMed • Google ScholarSearch for Su-Chun Zhang in:Nature

A indicator of visceral adipose dysfunction to evaluate metabolic health in adult Chinese

evaluate metabolic health in adult Chinese Ming-Feng Xia Ying Chen Huan-Dong Lin Hui Ma Xiao-Ming Li Qiqige Aleteng Qian Li Dan Wang Yu Hu Bai-shen Pan Xue-Jun Li Xiao-Ying Li Xin Gao OPEN Visceral adipose

Fault Diagnosis of Rotating Machinery Based on Multisensor Information Fusion Using SVM and Time-Domain Features

Multisensor information fusion, when applied to fault diagnosis, the time-space scope, and the quantity of information are expanded compared to what could be acquired by a single sensor, so the diagnostic object can be described more comprehensively. This paper presents a methodology of fault diagnosis in rotating machinery using multisensor information fusion that all the...

Recapitulation of spinal motor neuron-specific disease phenotypes in a human cell model of spinal muscular atrophy

Establishing human cell models of spinal muscular atrophy (SMA) to mimic motor neuron-specific phenotypes holds the key to understanding the pathogenesis of this devastating disease. Here, we developed a closely representative cell model of SMA by knocking down the disease-determining gene, survival motor neuron (SMN), in human embryonic stem cells (hESCs). Our study with this...

ADAR1 is required for differentiation and neural induction by regulating microRNA processing in a catalytically independent manner

Adenosine deaminases acting on RNA (ADARs) are involved in adenosine-to-inosine RNA editing and are implicated in development and diseases. Here we observed that ADAR1 deficiency in human embryonic stem cells (hESCs) significantly affected hESC differentiation and neural induction with widespread changes in mRNA and miRNA expression, including upregulation of self-renewal-related...

Characterization, pharmacokinetics, and hypoglycemic effect of berberine loaded solid lipid nanoparticles

Liu, Xue-jun Li, Shu-yu Yang Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, People’s Republic of China Abstract: The high aqueous solubility, poor permeability

Roles of vimentin and 14-3-3 zeta/delta in the inhibitory effects of heparin on PC-3M cell proliferation and B16-F10-luc-G5 cells metastasis

. Calyculin A-induced vimentin phosphorylYan PAN, Hong ZHOU, and Xue-jun LI designed research; ation sequesters 14-3-3 and displaces other 14-3-3 partners in vivo. Yan PAN, Li-jun ZHONG, Kui CHEN, Hao-peng YANG ... lesions of multiple formed research; Yan PAN, Xin WANG, and Li-jun ZHONG sclerosis binds to vimentin and glial fibrillary acidic protein in cultured analyzed data; Yan PAN and Xue-jun LI wrote the paper

Fezf2 Regulates Telencephalic Precursor Differentiation from Mouse Embryonic Stem Cells

The mechanisms by which transcription factors control stepwise lineage restriction during the specification of cortical neurons remain largely unknown. Here, we investigated the role of forebrain embryonic zinc finger like (Fezf2) in this process by generating Fezf2 knockdown and tetracycline-inducible Fezf2 overexpression mouse embryonic stem cell (mESC) lines. The...

Relationship of carotid intima-media thickness and duration of vegetarian diet in Chinese male vegetarians

Objective Many studies have shown that vegetarian diet has beneficial effects on the prevention of cardiovascular diseases. However, the effect of vegetarian diet on carotid intima-media thickness (IMT), as well as the association between IMT and duration of vegetarian diet, are still unclear. The present study aims to investigate the influence of duration of vegetarian diet on...

Stomatin Inhibits Pannexin-1-Mediated Whole-Cell Currents by Interacting with Its Carboxyl Terminal

The pannexin-1 (Panx1) channel (often referred to as the Panx1 hemichannel) is a large-conductance channel in the plasma membrane of many mammalian cells. While opening of the channel is potentially detrimental to the cell, little is known about how it is regulated under physiological conditions. Here we show that stomatin inhibited Panx1 channel activity. In transfected HEK-293...

Sinomenine influences capacity for invasion and migration in activated human monocytic THP-1 cells by inhibiting the expression of MMP-2, MMP-9, and CD147

-bin LIN designed the research; Yang-qiong OU and Li-hua CHEN performed the research; Xue-jun LI and Zhi-bin LIN contributed new analytical reagents and tools; Yang-qiong OU and Wei-dong LI analyzed the ... Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, ChinaYang-qiong Ou, Li-hua Chen, Xue-jun Li, Zhi-bin Lin & Wei-dong Li AuthorsSearch for Yang-qiong Ou in:Nature Research

Human embryonic stem cells for brain repair?

Cell therapy has been perceived as the main or ultimate goal of human embryonic stem (ES) cell research. Where are we now and how are we going to get there? There has been rapid success in devising in vitro protocols for differentiating human ES cells to neuroepithelial cells. Progress has also been made to guide these neural precursors further to more specialized neural cells...

GLB prevents tumor metastasis of Lewis lung carcinoma by inhibiting tumor adhesion actions

-jun LI 0 0 Department of Pharmacology, School of Basic Medical Sciences and State Key Laboratory of Natural Biomimetic Drugs, Peking University , Beijing 100083 , China 1 National Research Institute for

Specification of Region-Specific Neurons Including Forebrain Glutamatergic Neurons from Human Induced Pluripotent Stem Cells

: Connecticut Stem Cell Research Grants (http://www.ct.gov/dph/cwp/view.asp?a = 3142&q = 389700, #06SCD02 and 06SCB14). Xue-Jun Li: National Institutes of Health grant (http://grants.nih.gov/grants/funding/r21