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Morphine coordinates SST and PV interneurons in the prelimbic cortex to disinhibit pyramidal neurons and enhance reward

Opioids, such as morphine, are clinic analgesics which induce euphoria. Morphine exposure modifies the excitability and functional interactions between neurons, while the underlying cellular and molecular mechanisms, especially how morphine assembles heterogeneous interneurons (INs) in prelimbic cortex (PrL) to mediate disinhibition and reward, are not clear. Using approaches of...

Macrofungal species distributions depend on habitat partitioning of topography, light, and vegetation in a temperate mountain forest

, No.63 Agricultural Road, Zhengzhou, 450002, ChinaYun Chen, Zhiliang Yuan, Shuai Bi, Xueying Wang & Yongzhong YeSection for Ecoinformatics and Biodiversity, Department of Bioscience, Aarhus University ... • Google Scholar Search for Xueying Wang in:Nature Research journals • PubMed • Google Scholar Search for Yongzhong Ye in:Nature Research journals • PubMed • Google Scholar Search for Jens-Christian

Fast Fourier single-pixel imaging via binary illumination

. Author information AffiliationsDepartment of Optoelectronic Engineering, Jinan University, Guangzhou, 510632, ChinaZibang Zhang, Xueying Wang & Jingang ZhongBiomedical Engineering, University of ... Zhang in:Nature Research journals • PubMed • Google Scholar Search for Xueying Wang in:Nature Research journals • PubMed • Google Scholar Search for Guoan Zheng in:Nature Research journals • PubMed

An acute functional screen identifies an effective antibody targeting amyloid-β oligomers based on calcium imaging

Soluble amyloid β oligomers (AβOs) are widely recognized neurotoxins that trigger aberrant signaling in specific subsets of neurons, leading to accumulated neuronal damage and memory disorders in Alzheimer’s disease (AD). One of the profound downstream consequences of AβO-triggered events is dysregulation of cytosolic calcium concentration ([Ca2+]i), which has been implicated in...

The use of transformed IMR90 cell model to identify the potential extra-telomeric effects of hTERT in cell migration and DNA damage response

supported by Ministry of Education Academic Research Fund Tier 1 grants, R-183-000-320-112 to Xueying Wang, National University Health System (NUHS). Xu Cao and Chiou Mee Kong are recipients of research

Elite Model for the Generation of Induced Pluripotent Cancer Cells (iPCs)

Xueying Wang 0 Rajasingh Johnson, University of Kansas Medical Center, United States of America 0 Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore , Singapore

Regulation of hTERT by BCR-ABL at multiple levels in K562 cells

Juin Hsien Chai 0 Yong Zhang Wei Han Tan 0 Wee Joo Chng Baojie Li Xueying Wang 0 0 Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore , 8 Medical Drive ... Department of Biochemistry and Cancer Science Institute of Singapore, National University of Singapore. Dr Xueying Wang acknowledges funding support from the Academic Research Fund Tier 1 Faculty Research

Laser ablation of Dbx1 neurons in the pre-Bötzinger complex stops inspiratory rhythm and impairs output in neonatal mice

To understand the neural origins of rhythmic behavior one must characterize the central pattern generator circuit and quantify the population size needed to sustain functionality. Breathing-related interneurons of the brainstem pre-Bötzinger complex (preBötC) that putatively comprise the core respiratory rhythm generator in mammals are derived from Dbx1-expressing precursors...

Rapid telomere motions in live human cells analyzed by highly time-resolved microscopy

Background Telomeres cap chromosome ends and protect the genome. We studied individual telomeres in live human cancer cells. In capturing telomere motions using quantitative imaging to acquire complete high-resolution three-dimensional datasets every second for 200 seconds, telomere dynamics were systematically analyzed. Results The motility of individual telomeres within the...

Rapid telomere motions in live human cells analyzed by highly time-resolved microscopy

Telomeres cap chromosome ends and protect the genome. We studied individual telomeres in live human cancer cells. In capturing telomere motions using quantitative imaging to acquire complete high-resolution three-dimensional datasets every second for 200 seconds, telomere dynamics were systematically analyzed. The motility of individual telomeres within the same cancer cell...

Atm-deficient mice: an osteoporosis model with defective osteoblast differentiation and increased osteoclastogenesis

Atm is a Ser/Thr kinase involved in DNA damage response and is required for genome integrity and stem cell renewal. Here, we report an additional role for Atm in bone remodeling. Atm−/− mice showed reduced bone mass, especially at the trabecular bones, accompanied by a decrease in bone formation rate and defective differentiation of osteoblasts, but normal numbers of...