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The associations of DNA methylation alterations in oxidative stress-related genes with cancer incidence and mortality outcomes: a population-based cohort study

BackgroundReactive oxygen species may be involved in epigenetic gene activation or silencing. We aimed to identify CpG sites, at which DNA methylation is related to urinary 8-isoprostane levels (biomarker of lipid peroxidation) and cancer or mortality outcomes. This investigation was based on a German, population-based cohort with linkage to cancer and mortality registry data...

Deep representation for partially occluded face verification

University of Science and Technology. His interest includes machine learning and image processing. 4. Yan Zhang. She is a doctor candidate in Shandong University of Science and Technology. Her research

Mechanism and enhancement of lipid accumulation in filamentous oleaginous microalgae Tribonema minus under heterotrophic condition

The filamentous microalgae Tribonema minus accumulates large amounts of lipids under photoautotrophic condition, while under heterotrophic condition, the lipid content decreased dramatically. Determination of the differences in metabolic pathways between photoautotrophic and heterotrophic growth will provide targets and strategies for improvement of lipid accumulation in...

A Novel Process to Prepare Chitosan Macrospheres without Shrinkage and its Application to Immobilize β-Galactosidase

A new process for the preparation of chitosan macrospheres, which was simple and practicable, was suggested in this paper and various chitosans with different molecular weight were used as materials to immobilize β-galactosidase and the chitosan macrospheres with the lowest molecular weight (500 000) was selected as enzyme immobilization carrier based on the highest enzyme...

High-Index-Faceted Ni3S2 Branch Arrays as Bifunctional Electrocatalysts for Efficient Water Splitting

For efficient electrolysis of water for hydrogen generation or other value-added chemicals, it is highly relevant to develop low-temperature synthesis of low-cost and high-efficiency metal sulfide electrocatalysts on a large scale. Herein, we construct a new core–branch array and binder-free electrode by growing Ni3S2 nanoflake branches on an atomic-layer-deposited (ALD) TiO2...

The effects of pigment epithelium-derived factor on atherosclerosis: putative mechanisms of the process

Cardiovascular disease (CVD) is a leading cause of death worldwide. Atherosclerosis is believed to be the major cause of CVD, characterized by atherosclerotic lesion formation and plaque disruption. Although remarkable advances in understanding the mechanisms of atherosclerosis have been made, the application of these theories is still limited in the prevention and treatment of...

Global mapping of binding sites for phic31 integrase in transgenic maden-darby bovine kidney cells using ChIP-seq

BackgroundΦC31 integrase, a site-specific recombinase, can efficiently target attB-bearing transgenes to endogenous pseudo attP sites within mammalian genomes. The sequence features of endogenous binding sites will help us to fully understand the site-specific recognition function by ΦC31 integrase. The present study was aimed to uncover the global map of ΦC31 integrase binding...

Overexpression of apelin in Wharton’ jelly mesenchymal stem cell reverses insulin resistance and promotes pancreatic β cell proliferation in type 2 diabetic rats

BackgroundApelin plays a key beneficial role in energy metabolism by increasing glucose uptake and insulin sensitivity; however, apelin has a short half-life because it is rapidly cleared from the circulation limiting its therapeutic benefit. The aim of this study is to create a new approach to treat type 2 diabetes by inducing prolonged expression of apelin in Wharton’s jelly...

A Hybrid Dynamical Modelling and Control Approach for Energy Saving of Central Air Conditioning

to Yang Liu; nc.ude.tucs.liam@69y.l Received 1 February 2018; Revised 7 June 2018; Accepted 14 June 2018; Published 8 July 2018 Academic Editor: Bin Jiang Copyright © 2018 Yan Zhang et al. This is

The Impact of Egg Nutrient Composition and Its Consumption on Cholesterol Homeostasis

Nutrient deficiencies and excess are involved in many aspects of human health. As a source of essential nutrients, eggs have been used worldwide to support the nutritional needs of human societies. On the other hand, eggs also contain a significant amount of cholesterol, a lipid molecule that has been associated with the development of cardiovascular diseases. Whether the...

Importance of real-time RT-PCR to supplement the laboratory diagnosis in the measles elimination program in China

the testing through a high-quality control system. 10 / 12 Author Contributions Conceptualization: Yan Zhang, Wenbo Xu. Data curation: Aili Cui, Yan Zhang, Wenbo Xu. Formal analysis: Aili Cui ... , Naiying Mao, Huiling Wang, Songtao Xu, Zhen Zhu, Yixin Ji, Li Ren, Lingyu Gao. Funding acquisition: Aili Cui, Yan Zhang, Wenbo Xu. Methodology: Aili Cui, Yan Zhang, Wenbo Xu. Supervision: Yan Zhang

miR-34a exerts as a key regulator in the dedifferentiation of osteosarcoma via PAI-1–Sox2 axis

Osteosarcoma (OS) is a malignant bone cancer with severe chromosomal abnormalities and genetic aberrations. Our previous work reported the dedifferentiation of OS, which is related to poor prognosis. However, the molecular mechanism that regulates OS dedifferentiation is still a subject of exploration. Emerging evidence has suggested that microRNAs (miRNAs) are associated with...

The role of the Wnt/β-catenin signaling pathway in the proliferation of gold nanoparticle-treated human periodontal ligament stem cells

BackgroundSeveral studies have confirmed that gold nanoparticles (AuNPs) of specific concentration and size exert a boosting effect on cell proliferation; however, the mechanism through which this effect occurs remains unknown. This study explores the canonical Wnt signaling pathway in AuNP promotion of human periodontal ligament stem cell (hPDLSC) proliferation.MethodsMTS was...

Vitamin D status and epigenetic-based mortality risk score: strong independent and joint prediction of all-cause mortality in a population-based cohort study

BackgroundVitamin D deficiency and insufficiency have been established to be strongly associated with increased overall mortality and deaths from specific aging-related diseases. Recently, an epigenetic “mortality risk score” (MS) based on whole blood DNA methylation at the 10 most prominent mortality-related cytosine-phosphate-guanine (CpG) sites has also been found to be highly...


; Chinese Research Academy of Environmental Sciences, Beijing, China Yan Zhang and Yuchao Zhao State Key Joint Laboratory of Environmental Simulation and Pollution Control, School of Environment, Beijing ... . In particular, the Technical Guidelines for Address correspondence to Yan Zhang, Tel/fax: +86 10-5880-7596; E-mail: Environmental Risk Assessment for Projects (SEPA 2004) that were enacted in 2004

How Do Patients Perform in Establishing Informational Continuity of Care during Multi-Institutional Readmission in Rural China?

Zhang 0 0 Huazhong University of Science and Technology , People's Republic of China Introduction: Multi-institutional readmission refers to a 30-day readmission from one medical institution to another

Deep indicator for fine-grained classification of banana’s ripening stages

outperforms related state-of-the-art computer vision techniques in rough classification of banana maturity. All authors read and approved the final manuscript. Authors? information Yan Zhang is now a doctor

Litterfall and litter chemistry change over time in an old-growth temperate forest, northeastern China

• Litterfall and litter chemistry are key factors for the assessment of forest floor properties. A long-term study on litterfall, litter chemistry and forest basal areas was carried out in an old-growth temperate forest, northeastern China.• The objective of this study was to test whether forest floor properties in the old-growth forest remain relatively constant.• Litterfall...

Osthole inhibits gastric cancer cell proliferation through regulation of PI3K/AKT

project of Jiangsu province under Grant QNRC2016166 and Doctor Fund of Wuxi Health Bureau under Grant 2014BS01. Author Contributions Conceptualization: Yan Zhang. Data curation: Xiaojun Xu, Yan Zhang ... . Formal analysis: Xiaoyuan Liu, Yan Zhang. Funding acquisition: Yan Zhang. Methodology: Xiaojun Xu, Yan Zhang. Project administration: Yan Zhang. Resources: Yan Zhang. 8 / 10 Software: Xiaoyuan Liu, Yan