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Allosteric DNAzyme-based DNA logic circuit: operations and dynamic analysis

Recently, due to the dual roles of DNA and enzyme, DNAzyme has been widely used in the field of DNA circuit, which has a wide range of applications in bio-engineered system, information processing and biocomputing. In fact, the activity of DNAzymes was regulated by subunits assembly, pH control and metal ions triggers. However, those regulations required to change the sequences...

Association between previous schistosome infection and incident hyperuricemia: A prospective cohort study in China

Author Contributions Conceptualization: Chen Dong. The authors thank all the investigators who participated in the study and all the patients. Data curation: Guangli Wang, Yang Jing, Yi Ding, Jing Qiu ... . Formal analysis: Guangli Wang, Yang Jing. Funding acquisition: Hui Zhou, Chen Dong. Investigation: Guangli Wang, Yang Jing, Hui Zhou, Yi Ding, Jing Qiu. Methodology: Haiyong Hua, Chen Dong. Project

Entropy-driven DNA logic circuits regulated by DNAzyme

The catalytic DNA circuits play a critical role in engineered biological systems and molecular information processing. Actually, some of the natural or synthetic DNA circuits were triggered by covalent modifications, where conformational changes were induced to facilitate complex DNA engineering functions and signal transmissions. However, most of the reported artificial...

Low bone mineral density is associated with global coronary atherosclerotic plaque burden in stable angina patients

Low bone mineral density is associated with global coronary atherosclerotic plaque burden in stable angina patients Xue-qiang Guan,1 Yang-jing Xue,2 Jie Wang,2 Jun Ma,2 Yue-chun Li,2 Cheng Zheng,2

Application of the Bipotential Theory to a Nonassociated Drucker–Prager Model

should be addressed to Zhi-Qiang Feng; rf.yrve-vinu@gnef.gnaiqihz Received 14 December 2017; Accepted 1 March 2018; Published 21 May 2018 Academic Editor: Qiang Tang Copyright © 2018 Yang-Jing Zhou et

Pregnancy in polymyositis or dermatomyositis: retrospective results from a tertiary centre in China

Objective. To examine if patients with PM/DM are at higher risk of complicated pregnancies.

Life Cycle Analysis on Fossil Energy Ratio of Algal Biodiesel: Effects of Nitrogen Deficiency and Oil Extraction Technology

Life cycle assessment (LCA) has been widely used to analyze various pathways of biofuel preparation from “cradle to grave.” Effects of nitrogen supply for algae cultivation and technology of algal oil extraction on life cycle fossil energy ratio of biodiesel are assessed in this study. Life cycle fossil energy ratio of Chlorella vulgaris based biodiesel is improved by growing...

Life Cycle Analysis on Fossil Energy Ratio of Algal Biodiesel: Effects of Nitrogen Deficiency and Oil Extraction Technology

Life cycle assessment (LCA) has been widely used to analyze various pathways of biofuel preparation from “cradle to grave.” Effects of nitrogen supply for algae cultivation and technology of algal oil extraction on life cycle fossil energy ratio of biodiesel are assessed in this study. Life cycle fossil energy ratio of Chlorella vulgaris based biodiesel is improved by growing...

Pediatric Drug Nitazoxanide: A Potential Choice for Control of Zika

Zika virus (ZIKV) infection can be the cause of congenital malformations, including microcephaly in infants and can cause other disorders such as Guillain-Barré syndrome, meningoencephalitis, and myelitis, which can also occur in some infected adults. However, at this time, there is no drug approved to treat ZIKV infection. Drug repurposing is the promptest way to obtain an...

Preparation of Mesoporous SnO2 by Electrostatic Self-Assembly

Copyright © 2014 Yang Jing et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium

Preparation of Mesoporous SnO2 by Electrostatic Self-Assembly

Copyright © 2014 Yang Jing et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium

Parathyroid-specific epidermal growth factor-receptor inactivation prevents uremia-induced parathyroid hyperplasia in mice

In chronic kidney disease (CKD), parathyroid hyperplasia contributes to high serum parathyroid hormone (PTH) and also to an impaired suppression of secondary hyperparathyroidism by calcium, vitamin D and fibroblast growth factor 23 (FGF23). In rats, systemic inhibition of epidermal growth factor receptor (EGFR) activation markedly attenuated uremia-induced parathyroid hyperplasia...

Amifostine Pretreatment Attenuates Myocardial Ischemia/Reperfusion Injury by Inhibiting Apoptosis and Oxidative Stress

The present study was aimed at investigating the effect of amifostine on myocardial ischemia/reperfusion (I/R) injury of mice and H9c2 cells cultured with TBHP (tert-butyl hydroperoxide). The results showed that pretreatment with amifostine significantly attenuated cell apoptosis and death, accompanied by decreased reactive oxygen species (ROS) production and lower mitochondrial...

Activation of decidual invariant natural killer T cells promotes lipopolysaccharide-induced preterm birth

Invariant natural killer T (iNKT) cells are crucial for host defense against a variety of microbial pathogens, but the underlying mechanisms of iNKT cells activation by microbes are not fully explained. In this study, we investigated the molecular mechanisms of iNKT cell activation in lipopolysaccharide (LPS)-stimulated preterm birth using an adoptive transfer system and diverse...

Melatonin Upregulates the Activity of AMPK and Attenuates Lipid Accumulation in Alcohol-induced Rats

Melatonin is supposed to be an effective hepatoprotective agent. The effects and mechanisms of melatonin on alcoholic fatty liver (AFL) have not been well explored. The aim of this study was to investigate the preventive and therapeutic effects of melatonin on alcohol-induced fatty liver rats.

Stromal PD-L1 Expression Is Associated With Better Disease-Free Survival in Triple-Negative Breast Cancer

Objectives: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer, and there is no approved targeted therapy. We studied the expression of programmed cell death protein 1 (PD-1) and its ligand (PD-L1) in TNBC.

Role of Myeloma-Derived MIF in Myeloma Cell Adhesion to Bone Marrow and Chemotherapy Response

Background: Multiple myeloma (MM) remains an incurable cancer characterized by accumulation of malignant plasma cells in the bone marrow (BM). The mechanism underlying MM homing to BM is poorly elucidated.

Iptakalim confers an antidepressant effect in a chronic mild stress model of depression through regulating neuro-inflammation and neurogenesis

Depression is a serious mental disorder in the world, but the underlying mechanisms remain unclear and the effective cures are scarce. Iptakalim (Ipt), an ATP-sensitive potassium (K-ATP) channel opener that can cross the blood-brain barrier freely, has been demonstrated to inhibit neuro-inflammation and enhance adult hippocampal neurogenesis. But it is unknown whether Ipt is...