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Cross-species genomics identifies DLG2 as a tumor suppressor in osteosarcoma

notes These authors contributed equally: Yang W. Shao, Geoffrey A. Wood, Jinchang Lu. AffiliationsPrincess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, M5G 1L7, CanadaYang W. Shao ... AuthorsSearch for Yang W. Shao in:Nature Research journals • PubMed • Google Scholar Search for Geoffrey A. Wood in:Nature Research journals • PubMed • Google Scholar Search for Jinchang Lu in:Nature Research

Cell-Free DNA Provides a Good Representation of the Tumor Genome Despite Its Biased Fragmentation Patterns

Cell-free DNA (cfDNA) is short, extracellular, fragmented double-stranded DNA found in plasma. Plasma of patients with solid tumor has been found to show significantly increased quantities of cfDNA. Although currently poorly understood, the mechanism of cfDNA generation is speculated to be a product of genomic DNA fragmentation during cellular apoptosis and necrosis. Sequencing...

Circulating Tumor DNA Mutation Profiling by Targeted Next Generation Sequencing Provides Guidance for Personalized Treatments in Multiple Cancer Types

Search for Yang W. Shao in:Nature Research journals • PubMed • Google Scholar Contributions Y. Shu and Y.W. Shao: Designed and oversaw the project, and co-wrote the manuscript. X. Wu: Oversaw the project ... Geneseeq Technology Inc.. Corresponding author Correspondence to Yang W. Shao. Electronic supplementary material Supplementary Information Rights and permissions This work is licensed under a