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Prenatal Bisphenol A Exposure in Mice Induces Multitissue Multiomics Disruptions Linking to Cardiometabolic Disorders

The health impacts of endocrine-disrupting chemicals (EDCs) remain debated, and their tissue and molecular targets are poorly understood. In this study, we leveraged systems biology approaches to assess the target tissues, molecular pathways, and gene regulatory networks associated with prenatal exposure to the model EDC bisphenol A (BPA). Prenatal BPA exposure at 5 mg/kg/d, a...

Acute rejection after kidney transplantation promotes graft fibrosis with elevated adenosine level in rat

Aims Chronic allograft nephropathy is a worldwide issue with the major feature of progressive allograft fibrosis, eventually ending with graft loss. Adenosine has been demonstrated to play an important role in process of fibrosis. Our study aimed to investigate the relationship between adenosine and fibrosis in renal allograft acute rejection in rat. Materials and methods Wistar...

Stochastic fluctuations of permittivity coupling regulate seizure dynamics in partial epilepsy

Partial epilepsy is characterized by recurrent seizures that arise from a localized pathological brain region. During the onset of partial epilepsy, the seizure evolution commonly exhibits typical timescale separation phenomenon. This timescale separation behavior can be mimicked by a paradigmatic model termed as Epileptor, which consists of coupled fast-slow neural populations...

An Assessment Model of National Grants of University Based on Fuzzy Analytic Hierarchy Process

How to assess kinds of grants scientifically, effectively and regularly is an important topic for the funding workers to study. According to the national grants’ basic conditions, an assessment model is established on the basis of fuzzy analytic hierarchy process. And Finally an example is given to illustrate the scientificalness and operability of this model.

An Assessment Model of National Grants of University Based on Fuzzy Analytic Hierarchy Process

How to assess kinds of grants scientifically, effectively and regularly is an important topic for the funding workers to study. According to the national grants’ basic conditions, an assessment model is established on the basis of fuzzy analytic hierarchy process. And Finally an example is given to illustrate the scientificalness and operability of this model.

Carbon monoxide in an extremely metal-poor galaxy

GaoTianjin Astrophysics Center, Tianjin Normal University, Tianjin 300387, ChinaCai-Na Hao & Xiao-Yang Xia AuthorsSearch for Yong Shi in:Nature Research journals • PubMed • Google ScholarSearch for Junzhi Wang ... for Cai-Na Hao in:Nature Research journals • PubMed • Google ScholarSearch for Xiao-Yang Xia in:Nature Research journals • PubMed • Google ScholarSearch for Qiusheng Gu in:Nature Research journals

Use of polyvinylpyrrolidone-iodine solution for sterilisation and preservation improves mechanical properties and osteogenesis of allografts

Allografts eliminate the disadvantages associated with autografts and synthetic scaffolds but are associated with a disease-transmission risk. Therefore, allograft sterilisation is crucial. We aimed to determine whether polyvinylpyrrolidone-iodine (PVP-I) can be used for sterilisation and as a new wet-preservation method. PVP-I–sterilised and preserved allografts demonstrated...

Hepatitis B Virus Middle Protein Enhances IL-6 Production via p38 MAPK/NF-κB Pathways in an ER Stress-Dependent Manner

During hepatitis B virus (HBV) infection, three viral envelope proteins of HBV are overexpressed in the endoplasmic reticulum (ER). The large S protein (LHBs) and truncated middle S protein (MHBst) have been documented to play roles in regulating host gene expression and contribute to hepatic disease development. As a predominant protein at the ultrastructural level in biopsy...

Impact of Recombinant Globular Adiponectin on Early Warm Ischemia-Reperfusion Injury in Rat Bile Duct after Liver Transplantation

Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, ChinaYang Xia & Jian-Ping Gong AuthorsSearch for Yang Xia in:Nature Research journals • PubMed • Google ScholarSearch for Jian-Ping Gong

Safety and efficacy of an olive oil-based triple-chamber bag for parenteral nutrition: a prospective, randomized, multi-center clinical trial in China

Background Small studies suggest differences in efficacy and safety exist between olive oil-based (OLIVE) and soybean oil-based (SOYBEAN) parenteral nutrition regimens in hospitalized adult patients. This large, prospective, randomized (1:1), open-label, multi-center, noninferiority study compared the delivery, efficacy, and safety of OLIVE (N = 226) with SOYBEAN (N = 232) in...

A Mycobacterium bovis BCG-Naked DNA Prime-Boost Vaccination Strategy Induced CD4

Mycobacterium tuberculosis Immunogens Miao Lu 0 Zhi Yang Xia 0 Lang Bao 0 Beatrice Saviola 0 Laboratory of Infection and Immunity, School of Basic Medical Science, West China Center of Medical Sciences, Sichuan

Visualizing red blood cell sickling and the effects of inhibition of sphingosine kinase 1 using soft X-ray tomography

Sickle cell disease is a destructive genetic disorder characterized by the formation of fibrils of deoxygenated hemoglobin, leading to the red blood cell (RBC) morphology changes that underlie the clinical manifestations of this disease. Using cryogenic soft X-ray tomography (SXT), we characterized the morphology of sickled RBCs in terms of volume and the number of protrusions...

Altered Immune Profiles of Natural Killer Cells in Chronic Hepatitis B Patients: A Systematic Review and Meta-Analysis

Background Natural killer (NK) cells are the main effective component of the innate immune system that responds to chronic hepatitis B (CHB) infection. Although numerous studies have reported the immune profiles of NK cells in CHB patients, they are limited by inconsistent results. Thus, we performed a meta-analysis to characterize reliably the immune profiles of NK cells after...

Osthole confers neuroprotection against cortical stab wound injury and attenuates secondary brain injury

Background Neuroendoscopy is an innovative technique for neurosurgery that can nonetheless result in traumatic brain injury. The accompanying neuroinflammation may lead to secondary tissue damage, which is the major cause of delayed neuronal death after surgery. The present study investigated the capacity of osthole to prevent secondary brain injury and the underlying mechanism...

Dipping Process Characteristics Based on Image Processing of Pictures Captured by High-speed Cameras

The dipping process was recorded firstly by high-speed camera system; acceleration time, speed, and dipping time were set by the control system of dipping bed, respectively. By image processing of dipping process based on Otsu’s method, it was found that low-viscosity flux glue eliminates the micelle effectively, very low speed also leads to small micelle hidden between the bumps...

Mozart, Mozart Rhythm and Retrograde Mozart Effects: Evidences from Behaviours and Neurobiology Bases

 & Yang Xia These authors contributed equally to this work. AffiliationsKey Laboratory for NeuroInformation of Ministry of Education, Center for Information in Medicine, University of Electronic Science ... and Technology of China, Chengdu, 610054Yingshou Xing, Yang Xia, Keith Kendrick, Xiuxiu Liu, Maosen Wang, Dan Wu, Hua Yang, Wei Jing, Daqing Guo & Dezhong YaoSchool of Electronic Information Engineering

Regulation of Action Potential Waveforms by Axonal GABAA Receptors in Cortical Pyramidal Neurons

GABAA receptors distributed in somatodendritic compartments play critical roles in regulating neuronal activities, including spike timing and firing pattern; however, the properties and functions of GABAA receptors at the axon are still poorly understood. By recording from the cut end (bleb) of the main axon trunk of layer –5 pyramidal neurons in prefrontal cortical slices, we...

Altered Local Spontaneous Brain Activity in Juvenile Myoclonic Epilepsy: A Preliminary Resting-State fMRI Study

Zhong,2 Yongxiu Lai,1 Yang Xia,1 and Dezhong Yao1 1Key Laboratory for Neuroinformation of Ministry of Education, Center for Information in Medicine, High-Field Magnetic Resonance Brain Imaging Key

Altered Local Spontaneous Brain Activity in Juvenile Myoclonic Epilepsy: A Preliminary Resting-State fMRI Study

Zhong,2 Yongxiu Lai,1 Yang Xia,1 and Dezhong Yao1 1Key Laboratory for Neuroinformation of Ministry of Education, Center for Information in Medicine, High-Field Magnetic Resonance Brain Imaging Key