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Antibody-dependent enhancement of dengue virus infection inhibits RLR-mediated Type-I IFN-independent signalling through upregulation of cellular autophagy

Academy of Medical Sciences, and Peking Union Medical College, Kunming 650118, PR ChinaXinwei Huang, Yaofei Yue, Duo Li, Yujiao Zhao, Lijuan Qiu, Junying Chen, Yue Pan, Juemin Xi, Xiaodan Wang, Qiangming ... SunĀ & Qihan LiYunnan Key Laboratory of Vaccine Research & Development on Severe Infectious Diseases, Kunming 650118, PR ChinaXinwei Huang, Yaofei Yue, Duo Li, Yujiao Zhao, Lijuan Qiu, Junying Chen, Yue

Genetic Variability in L1 and L2 Genes of HPV-16 and HPV-58 in Southwest China

HPV account for most of the incidence of cervical cancer. Approximately 90% of anal cancers and a smaller subset (<50%) of other cancers (oropharyngeal, penile, vaginal, vulvar) are also attributed to HPV. The L1 protein comprising HPV vaccine formulations elicits high-titre neutralizing antibodies and confers type restricted protection. The L2 protein is a promising candidate...