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Dynamics Analysis of Neuron Bursting under the Modulation of Periodic Stimulation

A nonsmooth neuron model with periodic excitation which can reproduce spiking and bursting behavior of cortical neurons is investigated in this paper. Based on nonsmooth bifurcation analysis, the mechanism of the bursting behavior induced by slow-changing periodical stimulation as well as the associated evolution with the variation of the stimulation is explored. The modulating...

The Role of a Single Angiogenesis Inhibitor in the Treatment of Recurrent Glioblastoma Multiforme: A Meta-Analysis and Systematic Review

Background Currently, the standard treatment for newly diagnosed glioblastoma multiforme (GBM) is maximal safe surgical resection followed by radiation therapy with concurrent and adjuvant temozolomide. However, disease recurs in almost all patients, and the optimal salvage treatment for recurrent GBM remains unclear. We conducted a systematic review and meta-analysis of...

Mixed-Mode Oscillations in Nonautonomous Modified Chua’s Circuit

A nonautonomous system revised from Chua’s circuit with a cubic nonlinearity which could exhibit slow-fast effect is investigated in this paper. Inspired by slow-fast dynamical analysis, the external excitation is considered as a modulation parameter, which changes slowly and periodically. By introducing “transformed phase space,” bifurcation analysis of typical periodic mixed...

Mixed-Mode Oscillations in Nonautonomous Modified Chua’s Circuit

A nonautonomous system revised from Chua’s circuit with a cubic nonlinearity which could exhibit slow-fast effect is investigated in this paper. Inspired by slow-fast dynamical analysis, the external excitation is considered as a modulation parameter, which changes slowly and periodically. By introducing “transformed phase space,” bifurcation analysis of typical periodic mixed...

MicroRNA-655-3p functions as a tumor suppressor by regulating ADAM10 and β-catenin pathway in Hepatocellular Carcinoma

Background Increasing evidence suggests that microRNAs (miRNAs) play critical roles in malignant transformation, tumor progression and metastasis. Aberrant miR-655-3p expression has been associated with several cancers. However, the role and underlying mechanism of miR-655-3p in the development of hepatocellular carcinoma (HCC) remains unclear. Methods MiR-655-3p expression was...

Occurrence, temporal trends, and half-lives of perfluoroalkyl acids (PFAAs) in occupational workers in China

Paired serum and urine samples were collected from workers in a fluorochemical plant from 2008 to 2012 (n = 302) to investigate the level, temporal trends, and half-lives of PFAAs in workers of a fluorochemical plant. High levels of perfluorohexane sulfonate (PFHxS), perfluorooctanoic acid (PFOA), and perfluorooctanesulfonate (PFOS) were detected in serum with median...

Suppressive effect of exogenous carbon monoxide on endotoxin-stimulated platelet over-activation via the glycoprotein-mediated PI3K-Akt-GSK3β pathway

Platelet activation is an important event involved in the pathophysiological processes of the coagulation system. Clinical evidence has shown that platelets undergo distinctive pathological processes during sepsis. Unfortunately, how platelets physiologically respond to inflammation or sepsis is not well understood. In this study, we used a lipopolysaccharide (LPS)-stimulated...

Fouling analysis of membrane bioreactor treating antibiotic production wastewater at different hydraulic retention times

Membrane fouling, including foulants and factors, was investigated during hydraulic retention time (HRT) optimization of a membrane bioreactor (MBR) that treated wastewater from the production of antibiotics. The results showed that HRT played an important role in membrane fouling. Trans-membrane pressure (TMP), membrane flux, and resistance were stable at −6 kPa, 76 L m−2 h−1...

Emerging Persistent Organic Pollutants in Chinese Bohai Sea and Its Coastal Regions

Emerging persistent organic pollutants (POPs) have widely aroused public concern in recent years. Polybrominated diphenyl ethers (PBDEs) and perfluorooctane sulfonyl fluoride/perfluorooctane sulfonic acid (POSF/PFOS) had been newly listed in Stockholm Convention in 2009, and short chain chlorinated paraffins (SCCPs) and hexabromocyclododecanes (HBCDs) were listed as candidate...

Elevated levels of perfluoroalkyl acids in family members of occupationally exposed workers: the importance of dust transfer

of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, ChinaJianjie Fu, Yan Gao, Thanh Wang, Aiqian Zhang, Yawei Wang ... Research journals • PubMed • Google ScholarSearch for Yawei Wang in:Nature Research journals • PubMed • Google ScholarSearch for Guibin Jiang in:Nature Research journals • PubMed • Google Scholar

Protective Effect of Yinhua Miyanling Tablet on Lipopolysaccharide-Induced Inflammation through Suppression of NLRP3/Caspase-1 Inflammasome in Human Peripheral Blood Mononuclear Cells

,1,2 Lingxin Xiong,1,3 Jingtong Zheng,1 Chuangui Liu,3 Yanjiao Lu,1 Guoqiang Wang,1 Yawei Wang,1 Ting Wang,1 Xuewa Guan,1 Fang Chen,1 Keyong Fang,1 Chao Zhang,1 Junying Lu,1 Xiaotian Zhang,1 Hailin Zhu,3

Protective Effect of Yinhua Miyanling Tablet on Lipopolysaccharide-Induced Inflammation through Suppression of NLRP3/Caspase-1 Inflammasome in Human Peripheral Blood Mononuclear Cells

,1,2 Lingxin Xiong,1,3 Jingtong Zheng,1 Chuangui Liu,3 Yanjiao Lu,1 Guoqiang Wang,1 Yawei Wang,1 Ting Wang,1 Xuewa Guan,1 Fang Chen,1 Keyong Fang,1 Chao Zhang,1 Junying Lu,1 Xiaotian Zhang,1 Hailin Zhu,3

Low mir-372 expression correlates with poor prognosis and tumor metastasis in hepatocellular carcinoma

Background Recent studies have shown that miR-372 plays important roles in hepatocellular carcinoma (HCC) progression. However, results have been conflicting regarding its expression levels and role in HCC. Methods RT-PCR and in situ hybridization was used to evaluate miR-372 expression in HCC tissues and cell lines. The methylation status of neighboring CpG islands upstream of...

Hyperthermostable Thermotoga maritima xylanase XYN10B shows high activity at high temperatures in the presence of biomass-dissolving hydrophilic ionic liquids

The gene of Thermotoga maritima GH10 xylanase (TmXYN10B) was synthesised to study the extreme limits of this hyperthermostable enzyme at high temperatures in the presence of biomass-dissolving hydrophilic ionic liquids (ILs). TmXYN10B expressed from Pichia pastoris showed maximal activity at 100 °C and retained 92 % of maximal activity at 105 °C in a 30-min assay. Although the...

Microarray of surface-exposed proteins of rickettsia heilongjiangensis for serodiagnosis of Far-eastern spotted fever

Yong Qi 0 Wenping Gong 0 Xiaolu Xiong Jiafu Jiang Yawei Wang Jun Jiao Changsong Duan Bohai Wen 0 Equal contributors State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of

miR-372 down-regulates the oncogene ATAD2 to influence hepatocellular carcinoma proliferation and metastasis

Background ATAD2 is associated with many cellular processes, such as cell growth, migration and invasion. However, no studies have been conducted on the molecular biological function of the ATAD2 gene in hepatocellular carcinoma (HCC). Methods The protein and mRNA level expression of ATAD2 was examined in tissues and cell lines. Prognostic significance was analyzed by the Kaplan...