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Enhancer of zeste homolog 2-catalysed H3K27 trimethylation plays a key role in acute-on-chronic liver failure via TNF-mediated pathway

Acute-on-chronic liver failure is mainly due to host immunity self-destruction. The histone H3 lysine 27 (H3K27) trimethylating enzyme, enhancer of zeste homolog 2 (EZH2) mediates epigenetic silencing of gene expression and regulates immunity, also involves pathogenesis of several liver diseases. The current study was to determine the role of methyltransferase EZH2 and its...

Spreading to localized targets in complex networks

AffiliationsSchool of Systems Science, Beijing Normal University, Beijing 100875, P. R. ChinaYe Sun, Long Ma, An Zeng & Wen-Xu Wang AuthorsSearch for Ye Sun in:Nature Research journals • PubMed • Google ScholarSearch

Retinal expression of small non-coding RNAs in a murine model of proliferative retinopathy

Ocular neovascularization is a leading cause of blindness in proliferative retinopathy. Small non-coding RNAs (sncRNAs) play critical roles in both vascular and neuronal development of the retina through post-transcriptional regulation of target gene expression. To identify the function and therapeutic potential of sncRNAs in retinopathy, we assessed the expression profile of...

Gut microbiota of liver transplantation recipients

, Zhi-Gui Zeng, Ying Liu, Jian-Rui Zhang and Xiao-Ye Sun were involved in patient recruitment, sample collection and sample transportation. Zhi-Sheng Ye was involved in statistical analysis. Additional

Biocatalytic Production of Trehalose from Maltose by Using Whole Cells of Permeabilized Recombinant Escherichia coli

Trehalose is a non-reducing disaccharide, which can protect proteins, lipid membranes, and cells from desiccation, refrigeration, dehydration, and other harsh environments. Trehalose can be produced by different pathways and trehalose synthase pathway is a convenient, practical, and low-cost pathway for the industrial production of trehalose. In this study, 3 candidate treS genes...

2-Deoxyglucose Reverses the Promoting Effect of Insulin on Colorectal Cancer Cells In Vitro

An increased risk of colorectal cancer is related to the development of metabolic syndromes including hyperglycemia, and hyperinsulinemia. The high circulatory levels of glucose and/or insulin or the application of exogenous insulin may promote carcinogenesis, cancer progression and metastasis, which can be attributed to the Warburg effect or aerobic glycolysis. We attempted to...

Growth Simulation and Discrimination of Botrytis cinerea, Rhizopus stolonifer and Colletotrichum acutatum Using Hyperspectral Reflectance Imaging

This research aimed to develop a rapid and nondestructive method to model the growth and discrimination of spoilage fungi, like Botrytis cinerea, Rhizopus stolonifer and Colletotrichum acutatum, based on hyperspectral imaging system (HIS). A hyperspectral imaging system was used to measure the spectral response of fungi inoculated on potato dextrose agar plates and stored at 28°C...

VEGF amplifies transcription through ETS1 acetylation to enable angiogenesis

• PubMed • Google Scholar Search for Yi Fu in:Nature Research journals • PubMed • Google Scholar Search for Daniel S. Day in:Nature Research journals • PubMed • Google Scholar Search for Ye Sun in:Nature

Arg188 in rice sucrose transporter OsSUT1 is crucial for substrate transport

Background Plant sucrose uptake transporters (SUTs) are H+/sucrose symporters related to the major facilitator superfamily (MFS). SUTs are essential for plant growth but little is known about their transport mechanism. Recent work identified several conserved, charged amino acids within transmembrane spans (TMS) in SUTs that are essential for transport activity. Here we further...

A mouse model of urofacial syndrome with dysfunctional urination

Urofacial syndrome (UFS) is an autosomal recessive disease with severe dysfunctional urination including urinary incontinence (UI). Biallelic mutations of HPSE2 are discovered from UFS patients, suggesting that HPSE2 is a candidate disease gene. Here, we show that deletion of Hpse2 is sufficient to cause the UFS-like phenotype in mice. Hpse2 knockout mutants display a distended...

Rapid increase of scrub typhus incidence in Guangzhou, southern China, 2006―2014

Background In the last decade, scrub typhus (ST) has been emerging or re-emerging in some areas of Asia, including Guangzhou, one of the most affected endemic areas of ST in China. Methods Based on the data on all cases reported in Guangzhou from 2006 to 2014, we characterized the epidemiological features, and identified environmental determinants for the spatial distribution of...

Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis

Children’s Hospital, Harvard Medical School, Boston, MA, 02115, USAZhongjie Fu, Ye Sun & Lois SmithDepartment of Ophthalmology & Visual Sciences, University of Texas Medical Branch (UTMB), Galveston, TX, 77555 ... Research journals • PubMed • Google Scholar Search for Ye Sun in:Nature Research journals • PubMed • Google Scholar Search for Akrit Sodhi in:Nature Research journals • PubMed • Google Scholar Search for

H-RN, a peptide derived from hepatocyte growth factor, inhibits corneal neovascularization by inducing endothelial apoptosis and arresting the cell cycle

Background The goal of this study was to investigate the anti-angiogenic activity of a novel peptide H-RN, derived from the hepatocyte growth factor kringle 1 domain (HGF K1), in a mouse model of corneal neovascularization. The anti-angiogenic effect of H-RN on vascular endothelial growth factor (VEGF)-stimulated cell proliferation, cell migration and endothelial cell tube...

Risk Distribution of Human Infections with Avian Influenza H7N9 and H5N1 virus in China

Institute of Microbiology and Epidemiology, Beijing 100071, P. R. ChinaXin-Lou Li, Ye Sun, Wan-Jun Chen, Ruo-Xi Sun, Kun Liu, Mai-Juan Ma, Hong-Wu Yao, Li-Qun Fang & Wu-Chun CaoDepartment of Biostatistics ... • Google ScholarSearch for Ye Sun in:Nature Research journals • PubMed • Google ScholarSearch for Wan-Jun Chen in:Nature Research journals • PubMed • Google ScholarSearch for Ruo-Xi Sun in:Nature Research

Optimization of an Image-Guided Laser-Induced Choroidal Neovascularization Model in Mice

The mouse model of laser-induced choroidal neovascularization (CNV) has been used in studies of the exudative form of age-related macular degeneration using both the conventional slit lamp and a new image-guided laser system. A standardized protocol is needed for consistent results using this model, which has been lacking. We optimized details of laser-induced CNV using the image...

A Common Variant Of Ubiquinol-Cytochrome c Reductase Complex Is Associated with DDH

Purpose Genetic basis of Developmental dysplasia of the hip (DDH) remains largely unknown. To find new susceptibility genes for DDH, we carried out a genome-wide association study (GWAS) for DDH. Methods We enrolled 386 radiology confirmed DDH patients and 558 healthy controls (Set A) to conduct a genome-wide association study (GWAS). Quality-control was conducted at both the...

Identification of the relationship between Chinese Adiantum reniforme var. sinense and Canary Adiantum reniforme

Background There are different opinions about the relationship of two disjunctively distributed varieties Adiantum reniforme L. var. sinense Y.X.Lin and Adiantum reniforme L. Adiantum reniforme var. sinense is an endangered fern only distributed in a narrowed region of Chongqing city in China, while Adiantum reniforme var. reniforme just distributed in Canary Islands and Madeira...

Diagnosing and Predicting the Earth’s Health via Ecological Network Analysis

Ecological balance is one of the most attractive topics in biological, environmental, earth sciences, and so on. However, due to the complexity of ecosystems, it is not easy to find a perfect way to conclusively explain all the potential impacts. In this paper, by considering several important elements, we seek to build a dynamic network model to predict the Earth’s health...