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The Role of SKQ1 (Visomitin) in Inflammation and Wound Healing of the Ocular Surface

be published. Disclosures Yi Wei, Andrew Troger, Viola Spahiu, Natalia Perekhvatova, Maxim Skulachev, Anton Petrov, Boris Chernyak and Penny Asbell have nothing to disclose. Compliance with Ethics

Distinct mucosal microbial communities in infants with surgical necrotizing enterocolitis correlate with age and antibiotic exposure

NEC/non-NEC status had a much stronger effect on microbial richness than infant age. (TIF) Author Contributions Conceptualization: Joann Romano-Keeler, Yi-Wei Tang, Jo?rn-Hendrik Weitkamp. Data ... Tovchigrechko, Chunlin Wang, Robert M. Brucker, Daniel J. Moore, Christopher Fonnesbeck, Hernan Correa, Yi-Wei Tang, Lora Hooper, Seth R. Bordenstein, Suman R. Das, Jo?rn-Hendrik Weitkamp. Project

Cell sex affects extracellular matrix protein expression and proliferation of smooth muscle progenitor cells derived from human pluripotent stem cells

Background Smooth muscle progenitor cells (pSMCs) differentiated from human pluripotent stem cells (hPSCs) hold great promise for treating diseases or degenerative conditions involving smooth muscle pathologies. However, the therapeutic potential of pSMCs derived from men and women may be very different. Cell sex can exert a profound impact on the differentiation process of stem...

Synergistic activation of Arg1 gene by retinoic acid and IL-4 involves chromatin remodeling for transcription initiation and elongation coupling

-Wei Lin 0 Sung Wook Park 0 Li-Na Wei 0 0 Department of Pharmacology, Medical School, University of Minnesota , Minneapolis, MN 55455 , USA All-trans Retinoic acid (RA) and its derivatives are potent

SULF2 Expression Is a Potential Diagnostic and Prognostic Marker in Lung Cancer

Aims Lung cancer is one of the most deadly cancers; median survival from diagnosis is less than one year in those with advanced disease. Novel lung cancer biomarkers are desperately needed. In this study, we evaluated SULF2 expression by immunohistochemistry and its association with overall survival in a cohort of patients with non-small cell lung cancer (NSCLC). We also looked...

Levamisole-Adulterated Cocaine Nephrotoxicity Ultrastructural Features

Objectives: The issue of levamisole-adulterated cocaine is emerging as a rapidly growing public health concern due to an increasing number of reports describing its role in cutaneous vasculitis and agranulocytosis. Of note, levamisole is recognized as a contaminant in 69% of the cocaine used within the United States.

Inference of high resolution HLA types using genome-wide RNA or DNA sequencing reads

Background Accurate HLA typing at amino acid level (four-digit resolution) is critical in hematopoietic and organ transplantations, pathogenesis studies of autoimmune and infectious diseases, as well as the development of immunoncology therapies. With the rapid adoption of genome-wide sequencing in biomedical research, HLA typing based on transcriptome and whole exome/genome...

Transferring isolated mitochondria into tissue culture cells

Yi-Wei Yang 1 Michael D. Koob 0 1 0 Department of Laboratory Medicine and Pathology, Institutes for Translational Neuroscience (ITN) & of Human Genetics (IHG), University of Minnesota, Medical

Mdb1, a Fission Yeast Homolog of Human MDC1, Modulates DNA Damage Response and Mitotic Spindle Function

During eukaryotic DNA damage response (DDR), one of the earliest events is the phosphorylation of the C-terminal SQ motif of histone H2AX (H2A in yeasts). In human cells, phosphorylated H2AX (γH2AX) is recognized by MDC1, which serves as a binding platform for the accumulation of a myriad of DDR factors on chromatin regions surrounding DNA lesions. Despite its important role in...

Voluntary Alcohol Intake following Blast Exposure in a Rat Model of Mild Traumatic Brain Injury

Alcoholism is a frequent comorbidity following mild traumatic brain injury (mTBI), even in patients without a previous history of alcohol dependence. Despite this correlational relationship, the extent to which the neurological effects of mTBI contribute to the development of alcoholism is unknown. In this study, we used a rodent blast exposure model to investigate the...

Receptor-interacting protein 140 attenuates endoplasmic reticulum stress in neurons and protects against cell death

Inositol 1, 4, 5-trisphosphate receptor (IP3R)-mediated Ca2+ release from the endoplasmic reticulum (ER) triggers many physiological responses in neurons, and when uncontrolled can cause ER stress that contributes to neurological disease. Here we show that the unfolded protein response (UPR) in neurons induces rapid translocation of nuclear receptor-interacting protein 140...

Immune Mediators of protective and pathogenic immune responses in patients with mild and fatal human monocytotropic ehrlichiosis

Yi-Wei Tang 4 0 Department of Pathology, Meharry Medical College , Nashville, TN , USA 1 Department of Pathology, University of Pittsburgh , Pittsburgh, PA , USA 2 Department of Pathology, University

Simultaneous Detection and Differentiation of Human Papillomavirus Genotypes 6, 11, 16 and 18 by AllGlo Quadruplex Quantitative PCR

Background Human papillomaviruses (HPV) are classified into high-risk HPV and low-risk HPV. The most common high-risk HPV types in cervical cancer are HPV 16 and 18, and the most common low-risk types causing genital warts are HPV 6 and HPV 11. In this study, applying novel AllGlo fluorescent probes, we established a quadruplex quantitative PCR method to simultaneously detect and...

ERCC1 and ERCC2 Variants Predict Survival in Gastric Cancer Patients

Jaffer A. Ajani 0 Qing-Yi Wei 0 Xiaoping Miao, Tongji Medical College, Huazhong University of Science and Technology, China 0 1 Department of Epidemiology, the University of Texas MD Anderson Cancer

Estimating Risk of C. difficile Transmission from PCR Positive but Cytotoxin Negative Cases

Background The use of molecular methods to diagnose Clostridium difficile infection (CDI) has improved diagnostic yield compared to conventional methods. However, PCR testing can detect colonization and has introduced several practical challenges pertaining to need for treatment and isolation of cases. Methods For all new cases detected by real-time PCR, concurrent cytotoxin...

No Association between TGFB1 Polymorphisms and Late Radiotherapy Toxicity: A Meta-Analysis

BackgroundTransforming growth factor-beta 1 (TGF-β1) protein may be multifunctional and related to the development of fibrosis, induction of apoptosis, extracellular signaling and inhibition of proliferation in response to radiation-induced DNA damage. Several studies have investigated associations between single nucleotide polymorphisms (SNPs) in the TGFB1 gene and risk of late...

Rapid decrease in tumor perfusion following VEGF blockade predicts long-term tumor growth inhibition in preclinical tumor models

Vascular endothelial growth factor (VEGF) is a key upstream mediator of tumor angiogenesis, and blockade of VEGF can inhibit tumor angiogenesis and decrease tumor growth. However, not all tumors respond well to anti-VEGF therapy. Despite much effort, identification of early response biomarkers that correlate with long-term efficacy of anti-VEGF therapy has been difficult. These...

A Vaccine Targeted at CETP Alleviates High Fat and High Cholesterol Diet-Induced Atherosclerosis and Non-Alcoholic Steatohepatitis in Rabbit

Low HDL-C levels are associated with atherosclerosis and non-alcoholic steatohepatitis, and increased levels may reduce the risk of these diseases. Inhibition of cholesteryl ester transfer protein (CETP) activity is considered a promising strategy for increasing HDL-C levels. Since CETP is a self-antigen with low immunogenicity, we developed a novel CETP vaccine (Fc-CETP6) to...