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MG132 protects against renal dysfunction by regulating Akt-mediated inflammation in diabetic nephropathy

figure 3. Yi?Wei, Li-Ling?Yang and Qian?Zhang prepared figures 4?6. Qiong?Wu did data analysis prepared figures 7?8 and Table 1. Additional Information Competing Interests: The authors declare no

Decoding topologically associating domains with ultra-low resolution Hi-C data by graph structural entropy

• Google Scholar Search for Jimin Han in:Nature Research journals • PubMed • Google Scholar Search for Yi Wei in:Nature Research journals • PubMed • Google Scholar Search for Yun Deng in:Nature Research

Glyburide and retinoic acid synergize to promote wound healing by anti-inflammation and RIP140 degradation

-Wei Lin, Pu-Ste Liu, Kasey Ah Pook & Li-Na Wei AuthorsSearch for Yi-Wei Lin in:Nature Research journals • PubMed • Google Scholar Search for Pu-Ste Liu in:Nature Research journals • PubMed • Google

Characterization of the second- and third-harmonic optical susceptibilities of atomically thin tungsten diselenide

Research Foundation of Singapore (NRF-CRP Grant No. R-144-000-295-281). Author information Author notes Henrique G. Rosa and Yi Wei Ho contributed equally to this work. AffiliationsCentre for Advanced 2D ... Materials (CA2DM), National University of Singapore, 6 Science Drive 2, Singapore, 117546, SingaporeHenrique G. Rosa, Yi Wei Ho, Ivan Verzhbitskiy, Manuel J. F. L. Rodrigues, Goki Eda, Vitor M. Pereira & José

Gut microbiota from metabolic disease-resistant, macrophage-specific RIP140 knockdown mice improves metabolic phenotype and gastrointestinal integrity

, Minnesota, 55108, USADan Knights AuthorsSearch for Yi-Wei Lin in:Nature Research journals • PubMed • Google ScholarSearch for Emmanuel Montassier in:Nature Research journals • PubMed • Google ScholarSearch

NOD1 deficiency impairs CD44a/Lck as well as PI3K/Akt pathway

Pattern recognition receptors (PRRs) are crucial for host defense and tissue homeostasis against infecting pathogens. PRRs are highly conserved cross species, suggesting their key roles in fundamental biological processes. Though much have been learned for NOD1 receptor in the innate and adaptive immune responses, the roles of NOD1 during embryonic and larval stages remain poorly...

Low palaeoelevation of the northern Lhasa terrane during late Eocene: Fossil foraminifera and stable isotope evidence from the Gerze Basin

The Lhasa terrane is a key region for understanding the paleoelevation of the southern Tibetan Plateau after India-Asia collision. The Gerze Basin, located in the northern part of the Lhasa terrane, is a shortening-related basin. We discovered Lagena laevis (Bandy) fossils in upper Eocene strata of the Gerze Basin. This type of foraminifera is associated with lagoon and estuarine...

MiR-124 inhibits the migration and invasion of human hepatocellular carcinoma cells by suppressing integrin αV expression

Tumor metastasis is the major cause of cancer-related death especially in human hepatocellular carcinoma (HCC). Although microRNAs have been implicated in tumor development, the roles of miR-124 in HCC metastasis are still not well understood. We conducted functional analysis in this study to investigate miR-124. We observed that miR-124 significantly retarded the wound healing...

Very Early Colorectal Anastomotic Leakage within 5 Post-operative Days: a More Severe Subtype Needs Relaparatomy

Early anastomotic leakage (AL), usually defined as leakage within 30 post-operative days, represents a severe entity. However, mounting evidence has indicated that majorities of leakage occur within one week after surgery, making late AL rarity. Here we analyzed 101 consecutive colorectal AL, all of which occurred within 30 post-operative days, during Jan 2013 and Dec 2015 in...

Recombinant Adeno-Associated Virus-Mediated Expression of Methamphetamine Antibody Attenuates Methamphetamine-Induced Hyperactivity in Mice

Methamphetamine (Meth) is one of the most frequently abused drugs worldwide. Recent studies have indicated that antibodies with high affinity for Meth reduce its pharmacological effects. The purpose of this study was to develop a technique for virus-based passive immunization against Meth effects. We generated a recombinant adeno-associated virus serotype-8 vector (AAV-MethAb...

Musashi-1 Enhances Glioblastoma Cell Migration and Cytoskeletal Dynamics through Translational Inhibition of Tensin3

. AffiliationsInstitute of Clinical Medicine, National Yang-Ming University, Taipei, TaiwanHsiao-Yun Chen, Yi-Wei Chen, Pin-I Huang & Shih-Hwa ChiouStem Cell Center, Department of Medical Research, Taipei Veterans General ... Pau-Yuan Chen in:Nature Research journals • PubMed • Google Scholar Search for Hsin-I Ma in:Nature Research journals • PubMed • Google Scholar Search for Yi-Wei Chen in:Nature Research journals

Low-photon-number optical switch and AND/OR logic gates based on quantum dot-bimodal cavity coupling system

. AffiliationsState Key Laboratory of Information Photonics and Optical Communications, Beijing University of Posts and Telecommunications, Beijing 100876, ChinaShen Ma, Han Ye, Zhong-Yuan Yu, Wen Zhang, Yi-Wei Peng ... in:Nature Research journals • PubMed • Google ScholarSearch for Wen Zhang in:Nature Research journals • PubMed • Google ScholarSearch for Yi-Wei Peng in:Nature Research journals • PubMed • Google

Module organization and variance in protein-protein interaction networks

Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, TaiwanChun-Yu Lin, Tsai-Ling Lee, Yi-Yuan Chiu, Yi-Wei Lin, Yu-Shu Lo, Chih-Ta Lin & Jinn-Moon YangDepartment of Biological Science and ... • PubMed • Google ScholarSearch for Yi-Yuan Chiu in:Nature Research journals • PubMed • Google ScholarSearch for Yi-Wei Lin in:Nature Research journals • PubMed • Google ScholarSearch for Yu-Shu Lo in:Nature

Receptor-interacting protein 140 attenuates endoplasmic reticulum stress in neurons and protects against cell death

Inositol 1, 4, 5-trisphosphate receptor (IP3R)-mediated Ca2+ release from the endoplasmic reticulum (ER) triggers many physiological responses in neurons, and when uncontrolled can cause ER stress that contributes to neurological disease. Here we show that the unfolded protein response (UPR) in neurons induces rapid translocation of nuclear receptor-interacting protein 140...

Fecal bacterial microbiome diversity in chronic HIV-infected patients in China

The purpose of this study was to identify fecal bacterial microbiome changes in patients with chronic human immunodeficiency virus (HIV) infection in China. Bacterial 16S rRNA genes were amplified, sequenced (454 pyrosequencing), and clustered into operational taxonomic units using the QIIME software. Relative abundance at the phylum and genus levels were calculated. Alpha...

Asymmetric trapping of zwitterionic intermediates by sulphur ylides in a palladium-catalysed decarboxylation-cycloaddition sequence

Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei 430079, ChinaTian-Ren Li, Fen Tan, Liang-Qiu Lu, Yi Wei, Ya-Ni Wang, Yi-Yin Liu, Qing-Qing Yang, Jia-Rong Chen, De-Qing Shi & Wen-Jing ... Tan in:Nature Research journals • PubMed • Google ScholarSearch for Liang-Qiu Lu in:Nature Research journals • PubMed • Google ScholarSearch for Yi Wei in:Nature Research journals • PubMed • Google

Quasi-steady-state air plasma channel produced by a femtosecond laser pulse sequence

ScholarSearch for Yu-Tong Li in:Nature Research journals • PubMed • Google ScholarSearch for Li-Ming Chen in:Nature Research journals • PubMed • Google ScholarSearch for Zhi-Yi Wei in:Nature Research journals ... Physics, Chinese Academy of Sciences, Beijing 100190, ChinaXin Lu, Shi-You Chen, Jing-Long Ma, Lei Hou, Guo-Qian Liao, Jin-Guang Wang, Yu-Jing Han, Hao Teng, Hai-Nian Han, Yu-Tong Li, Li-Ming Chen, Zhi-Yi

Targeting multiple signal pathways by chemopreventive agents for cancer prevention and therapy

In recent years, growing interest has been focused on the field of cancer prevention. Cancer prevention by chemopreventive agents offers significant promise for reducing the incidence and mortality of cancer. Chemopreventive agents may exert their effects either by blocking or metabolizing carcinogens or by inhibiting tumor cell growth. Another important benefit of...